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    Fife [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38337, updated on 10-May-2024

    Summary

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    Official Symbol
    Fifeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264606
    Locus tag
    Dmel_CG43955
    See related
    AllianceGenome:FB:FBgn0264606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey171; CG12187; CG14950; CG16976; CG43375; CG43955; Dmel\CG43955; fife
    Old locus tag
    Dmel_CG12187; Dmel_CG14950; Dmel_CG16976; Dmel_CG43375
    Summary
    Predicted to enable transmembrane transporter binding activity. Involved in positive regulation of transport; presynaptic active zone assembly; and synaptic vesicle clustering. Located in cytoskeleton of presynaptic active zone. Is expressed in adult head and embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Fife in Genome Data Viewer
    Location:
    62E8-62F1; 3-4 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2655415..2711690, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2655415..2711690, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Prolyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Snurportin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Myocardin-related transcription factor Neighboring gene Accessory gland protein 62F Neighboring gene Novel nucleolar protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release. Bruckner JJ, et al. J Cell Biol, 2017 Jan 2. PMID 27998991, Free PMC Article
    2. Fife, a Drosophila Piccolo-RIM homolog, promotes active zone organization and neurotransmitter release. Bruckner JJ, et al. J Neurosci, 2012 Nov 28. PMID 23197698, Free PMC Article
    3. Linkage of A-to-I RNA Editing in Metazoans and the Impact on Genome Evolution. Duan Y, et al. Mol Biol Evol, 2018 Jan 1. PMID 29048557, Free PMC Article
    4. RIM-binding protein couples synaptic vesicle recruitment to release sites. Petzoldt AG, et al. J Cell Biol, 2020 Jul 6. PMID 32369542, Free PMC Article
    5. t-GRASP, a targeted GRASP for assessing neuronal connectivity. Shearin HK, et al. J Neurosci Methods, 2018 Aug 1. PMID 29792886, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic active zone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoskeleton of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fife
    Names
    CG43955-PB
    CG43955-PD
    CG43955-PF
    CG43955-PG
    Fife-PB
    Fife-PD
    Fife-PF
    Fife-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2655415..2711690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274411.1 → NP_001261340.1  fife, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE32
      Conserved Domains (5) summary
      cd04031
      Location:651 → 779
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      COG0265
      Location:526 → 577
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:491 → 580
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15751
      Location:130 → 187
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo
      cl14603
      Location:1163 → 1304
      C2; C2 domain

    2. NM_001274409.2 → NP_001261338.1  fife, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDV6
      Conserved Domains (4) summary
      cd04031
      Location:651 → 779
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      COG0265
      Location:526 → 577
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:491 → 580
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15751
      Location:130 → 187
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    3. NM_139485.2 → NP_647742.1  fife, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU40, Q9VZY3
      Related
      FBpp0305806
      Conserved Domains (3) summary
      COG0265
      Location:526 → 577
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:491 → 580
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15751
      Location:130 → 187
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo

    4. NM_001274410.1 → NP_001261339.1  fife, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU40, Q9VZY3
      Conserved Domains (3) summary
      COG0265
      Location:526 → 577
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:491 → 580
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15751
      Location:130 → 187
      FYVE_BSN_PCLO; FYVE-related domain found in protein bassoon and piccolo
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDV6 M9PDV6
    M9PE32 M9PE32
    Q86NW3 Q86NW3
    Q9VZY3 Q9VZY3

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