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    alp-1 LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp [ Caenorhabditis elegans ]

    Gene ID: 177701, updated on 12-Jun-2024

    Summary

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    Gene symbol
    alp-1
    Gene description
    LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp
    Locus tag
    CELE_T11B7.4
    See related
    AllianceGenome:WB:WBGene00001132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Involved in determination of adult lifespan and pharyngeal pumping. Located in several cellular components, including actin filament bundle; basal part of cell; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; nervous system; and pharynx. Used to study cardiomyopathy and myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to several human genes including LDB3 (LIM domain binding 3); PDLIM5 (PDZ and LIM domain 5); and PDLIM7 (PDZ and LIM domain 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See alp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (8852494..8862246)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene pseudo Neighboring gene Secreted protein Neighboring gene GtrA-like protein domain-containing protein;Rhomboid domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene C6 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. McKeown CR, et al. Dev Dyn, 2006 Feb. PMID 16278882, Free PMC Article
    2. The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Han HF, et al. Mol Biol Cell, 2009 May. PMID 19261811, Free PMC Article
    3. The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway. Shimizu T, et al. Cell Rep, 2018 Aug 14. PMID 30110643
    4. Long-lived worms and aging. Luo Y. Redox Rep, 2004. PMID 15231060
    5. ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration. Lecroisey C, et al. Mol Biol Cell, 2013 Apr. PMID 23427270, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALP-1 serves as a platform to activate MLC-4 phosphorylation mediated by the RHO-1-LET-502 signaling pathway.
      Title: The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway.
    2. new roles for the ALP/Enigma protein family that may lead to the understanding of their involvement in cardiomyopathy
      Title: Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.
    3. ALP-1 and alpha-actinin function together to stabilize actin filaments and promote muscle structural integrity.
      Title: The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM zinc-binding domain-containing protein;PDZ and LIM domain protein Zasp
    NP_001023370.1
    • Confirmed by transcript evidence
    NP_001023371.1
    • Confirmed by transcript evidence
    NP_001040987.1
    • Confirmed by transcript evidence
    NP_001367079.1
    • Confirmed by transcript evidence
    NP_501534.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8852494..8862246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047522.4 → NP_001040987.1  PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFG1
      Conserved Domains (7) summary
      smart00735
      Location:137 → 162
      ZM; ZASP-like motif
      cd09360
      Location:220 → 271
      LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family
      cd09455
      Location:511 → 564
      LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function
      cd09461
      Location:631 → 684
      LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function
      cd00992
      Location:5 → 80
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:137 → 197
      DUF4749; Domain of unknown function (DUF4749)
      cl02475
      Location:572 → 623
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_069133.5 → NP_501534.2  PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501534.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEL1
      Conserved Domains (7) summary
      smart00735
      Location:137 → 162
      ZM; ZASP-like motif
      cd09360
      Location:220 → 271
      LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family
      cd09455
      Location:472 → 525
      LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function
      cd09461
      Location:592 → 645
      LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function
      cd00992
      Location:5 → 80
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:137 → 197
      DUF4749; Domain of unknown function (DUF4749)
      cl02475
      Location:533 → 584
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001028200.6 → NP_001023371.1  PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFL5
      Conserved Domains (7) summary
      smart00735
      Location:137 → 162
      ZM; ZASP-like motif
      cd09360
      Location:220 → 271
      LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family
      cd09455
      Location:1251 → 1304
      LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function
      cd09461
      Location:1371 → 1424
      LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function
      cd00992
      Location:5 → 80
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:137 → 197
      DUF4749; Domain of unknown function (DUF4749)
      cl02475
      Location:1312 → 1363
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. NM_001380387.2 → NP_001367079.1  PDZ and LIM domain protein Zasp [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC72
      Conserved Domains (4) summary
      smart00735
      Location:137 → 162
      ZM; ZASP-like motif
      cd09360
      Location:220 → 271
      LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family
      cd00992
      Location:5 → 80
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam15936
      Location:137 → 199
      DUF4749; Domain of unknown function (DUF4749)

    5. NM_001028199.5 → NP_001023370.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023370.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEF6
      Conserved Domains (6) summary
      smart00735
      Location:66 → 91
      ZM; ZASP-like motif
      cd09360
      Location:149 → 200
      LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family
      cd09455
      Location:598 → 651
      LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function
      cd09461
      Location:718 → 771
      LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function
      pfam15936
      Location:66 → 126
      DUF4749; Domain of unknown function (DUF4749)
      cl02475
      Location:659 → 710
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
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