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    Zfp759 zinc finger protein 759 [ Mus musculus (house mouse) ]

    Gene ID: 268670, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp759provided by MGI
    Official Full Name
    zinc finger protein 759provided by MGI
    Primary source
    MGI:MGI:2446280
    See related
    Ensembl:ENSMUSG00000057396 AllianceGenome:MGI:2446280
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan8; Rslcan-8
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to several human genes including ZNF208 (zinc finger protein 208); ZNF43 (zinc finger protein 43); and ZNF721 (zinc finger protein 721). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 1.3), CNS E18 (RPKM 1.1) and 22 other tissues See more
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    Genomic context

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    See Zfp759 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67273040..67290468)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67121659..67142404)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 708 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene regulator of sex-limitation candidate 18 Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1 Neighboring gene protein FAM220A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
    2. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 759
    Names
    regulator of sex-limitation candidate 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172392.3 → NP_765980.3  zinc finger protein 759

      See identical proteins and their annotated locations for NP_765980.3

      Status: PROVISIONAL

      Source sequence(s)
      BK001631
      Consensus CDS
      CCDS49299.1
      UniProtKB/TrEMBL
      Q7M6X3
      Related
      ENSMUSP00000049650.8, ENSMUST00000052716.8
      Conserved Domains (6) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:272 → 713
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:472 → 488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:177 → 199
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67273040..67290468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247274.1 → XP_030103134.1  zinc finger protein 759 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:11 → 69
      KRAB; krueppel associated box
      COG5048
      Location:138 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:478 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030247272.2 → XP_030103132.1  zinc finger protein 759 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:31 → 89
      KRAB; krueppel associated box
      COG5048
      Location:158 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:330 → 350
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:498 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006517253.5 → XP_006517316.1  zinc finger protein 759 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:31 → 89
      KRAB; krueppel associated box
      COG5048
      Location:158 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:330 → 350
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:498 → 514
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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