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    CYSLTR1 cysteinyl leukotriene receptor 1 [ Homo sapiens (human) ]

    Gene ID: 10800, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CYSLTR1provided by HGNC
    Official Full Name
    cysteinyl leukotriene receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:17451
    See related
    Ensembl:ENSG00000173198 MIM:300201; AllianceGenome:HGNC:17451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYSLT1; CYSLTR; CYSLT1R; HMTMF81
    Summary
    This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in urinary bladder (RPKM 6.1), spleen (RPKM 5.2) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CYSLTR1 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (78271468..78327611, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76708793..76764940, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77526965..77583108, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C, pseudogene Neighboring gene uncharacterized LOC107985669 Neighboring gene MPRA-validated peak7397 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29787 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:77769873-77770852 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 34 Neighboring gene UBE2V1 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children. Zhao M, et al. Eur Arch Otorhinolaryngol, 2021 Dec. PMID 33837837
    2. Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells. Koller A, et al. Sci Rep, 2020 Oct 19. PMID 33077798, Free PMC Article
    3. Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution. Rabinovitch N, et al. Epigenetics, 2021 Jan-Feb. PMID 32657253, Free PMC Article
    4. Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells. Satapathy SR, et al. Cancer Lett, 2020 Sep 28. PMID 32474153
    5. CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis. Qin ZL, et al. Allergy, 2020 Apr. PMID 31732973

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
      Title: DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
    2. Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
      Title: Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.
    3. The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.
      Title: The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.
    4. CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis.
      Title: CysLT1R expression on ILC2s and effects of CysLT1R antagonist on ILC2 activity in patients with allergic rhinitis.
    5. Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.
      Title: Cysteinyl leukotriene receptor 1 promotes 5-fluorouracil resistance and resistance-derived stemness in colon cancer cells.
    6. Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells.
      Title: Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells.
    7. Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
      Title: Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
    8. Drugs antagonizing the CysLT1 receptor, termed lukasts and typified by montelukast, are established therapeutics for clinical management of asthma.. Here we describe recent data indicating that montelukast may be used for prevention and treatment of AAA, thus representing a promising pharmacological tool for a deadly vascular disease with significant socio-economic impact.
      Title: Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm.
    9. findings strongly implicate that cysLTR1 has the capacity to regulate cellular senescence in chondrocytes. It is suggested that montelukast may be a potential therapeutic agent for chondro-protective therapy.
      Title: Antagonism of cysteinyl leukotriene receptor 1 (cysLTR1) by montelukast suppresses cell senescence of chondrocytes.
    10. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children
      Title: Expression of cysteinyl leukotriene receptor 1 and 2 (CysLTR1 and CysLTR2) in the lymphocytes of hyperplastic tonsils: comparison between allergic and nonallergic snoring children.
    Submit: New GeneRIF Correction See all GeneRIFs (68)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of cysteinyl leukotriene receptor 1 (CYSLTR1) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46139

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteinyl leukotriene receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory gaseous exchange by respiratory system TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cysteinyl leukotriene receptor 1
    Names
    G-protein coupled receptor HG55
    LTD4 receptor
    cysteinyl leukotriene D4 receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012809.1 RefSeqGene

      Range
      4980..61123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282186.2 → NP_001269115.1  cysteinyl leukotriene receptor 1

      See identical proteins and their annotated locations for NP_001269115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AF133266, DQ131799, DQ131800, DQ131803
      Consensus CDS
      CCDS14439.1
      UniProtKB/Swiss-Prot
      B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
      Related
      ENSP00000478492.1, ENST00000614798.1
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32 → 163
      7tm_4; Olfactory receptor

    2. NM_001282187.2 → NP_001269116.1  cysteinyl leukotriene receptor 1

      See identical proteins and their annotated locations for NP_001269116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AF133266, DQ131799, DQ131801, DQ131803
      Consensus CDS
      CCDS14439.1
      UniProtKB/Swiss-Prot
      B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32 → 163
      7tm_4; Olfactory receptor

    3. NM_001282188.2 → NP_001269117.1  cysteinyl leukotriene receptor 1

      See identical proteins and their annotated locations for NP_001269117.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AF133266, DQ131799, DQ131802, DQ131803
      Consensus CDS
      CCDS14439.1
      UniProtKB/Swiss-Prot
      B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32 → 163
      7tm_4; Olfactory receptor

    4. NM_006639.4 → NP_006630.1  cysteinyl leukotriene receptor 1

      See identical proteins and their annotated locations for NP_006630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AF133266, DQ131799, DQ131803
      Consensus CDS
      CCDS14439.1
      UniProtKB/Swiss-Prot
      B2R954, D3DTE4, Q5JS94, Q8IV19, Q9Y271
      Related
      ENSP00000362401.3, ENST00000373304.4
      Conserved Domains (2) summary
      pfam00001
      Location:40 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:32 → 163
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      78271468..78327611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      76708793..76764940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y271.1 GenPept UniProtKB/Swiss-Prot:Q9Y271

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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