Morc3 microrchidia 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Morc3provided by MGI
Official Full Name: microrchidia 3provided by MGI
Primary source: MGI:MGI:2136841
See related: Ensembl:ENSMUSG00000039456 AllianceGenome:MGI:2136841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NXP2; Zcwcc3; D16Jhu32e; 1110051N18Rik
Summary: Predicted to enable methylated histone binding activity. Acts upstream of or within post-embryonic development. Located in PML body. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 54.88 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (93629009..93672964)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (93832121..93876077)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.
Title: The role of MORC3 in silencing transposable elements in mouse embryonic stem cells.
Data show that the MORC3 N-terminal ATPase domain forms a dimer when bound to AMPPNP.
Title: Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.
Data indicate that Morc3 mutation leads to altered nuclear localization of the protein, and upregulation of the IFN-beta /STAT1 pathway, which plays a critical role in the maintenance of bone homeostasis. These findings establish Morc3 as a previously unreported regulator of cortical bone homeostasis and haematopoietic stem cells niche, accompanied by altered bone cell differentiation.
Title: Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.
MORC3 colocalizes with PML by a two-step molecular mechanism.
Title: Two-step colocalization of MORC3 with PML nuclear bodies.
MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal fibroblasts but not p53-/- fibroblasts
Title: Dynamic regulation of p53 subnuclear localization and senescence by MORC3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI452146 (e-PCR)
- UniSTS:160598

G67816 (e-PCR)
- UniSTS:226162

D16Jhu32e (e-PCR), detects polymorphism
- UniSTS:226163

1110051N18Rik (e-PCR), detects polymorphism
- UniSTS:259014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of protein location in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
is_active_in PML body	ISO Inferred from Sequence Orthology more info
located_in PML body	ISO Inferred from Sequence Orthology more info	PubMed
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MORC family CW-type zinc finger protein 3

Names: nuclear matrix protein 2; zinc finger CW-type coiled-coil domain protein 3; zinc finger, CW-type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045529.3 → NP_001038994.2 MORC family CW-type zinc finger protein 3

Status: VALIDATED

Source sequence(s)

AK172896, BC098072

Consensus CDS

CCDS79490.1

UniProtKB/Swiss-Prot

A6H605, F7BJB9, Q4QQR6, Q6A0C2, Q8R0R0

Related

ENSMUSP00000144369.2, ENSMUST00000202261.5

Conserved Domains (4) summary

pfam07496
Location:409 → 446

zf-CW; CW-type Zinc Finger

cl00075
Location:29 → 136

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cl09111
Location:768 → 875

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

cl21462
Location:698 → 721

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

93629009..93672964

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523060.4 → XP_006523123.1 MORC family CW-type zinc finger protein 3 isoform X1

Conserved Domains (4) summary

TIGR02168
Location:629 → 810

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam07496
Location:340 → 377

zf-CW; CW-type Zinc Finger

pfam17942
Location:180 → 313

Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

cl00075
Location:14 → 66

HATPase; Histidine kinase-like ATPase domain