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    Klf3 Kruppel-like transcription factor 3 (basic) [ Mus musculus (house mouse) ]

    Gene ID: 16599, updated on 12-May-2024

    Summary

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    Official Symbol
    Klf3provided by MGI
    Official Full Name
    Kruppel-like transcription factor 3 (basic)provided by MGI
    Primary source
    MGI:MGI:1342773
    See related
    Ensembl:ENSMUSG00000029178 AllianceGenome:MGI:1342773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bklf; Tef-2; 9930027G08Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human KLF3 (Kruppel like factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 33.8), thymus adult (RPKM 20.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 C3.1; 5 33.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64960864..64990246)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64803521..64832901)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13223 Neighboring gene predicted gene, 54285 Neighboring gene STARR-positive B cell enhancer mm9_chr5:65053140-65053441 Neighboring gene STARR-positive B cell enhancer mm9_chr5:65053800-65054101 Neighboring gene STARR-seq mESC enhancer starr_13227 Neighboring gene STARR-seq mESC enhancer starr_13228 Neighboring gene uncharacterized LOC105244755 Neighboring gene STARR-seq mESC enhancer starr_13234 Neighboring gene STARR-seq mESC enhancer starr_13235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65155737-65155920 Neighboring gene STARR-positive B cell enhancer ABC_E10322 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:65197351-65197625 Neighboring gene predicted gene, 54286 Neighboring gene STARR-seq mESC enhancer starr_13242 Neighboring gene predicted gene, 31684 Neighboring gene STARR-seq mESC enhancer starr_13247 Neighboring gene predicted gene, 57736 Neighboring gene VISTA enhancer mm1725 Neighboring gene STARR-positive B cell enhancer ABC_E8057 Neighboring gene STARR-positive B cell enhancer ABC_E8058 Neighboring gene predicted gene, 31889

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells. Hao J, et al. Cell Prolif, 2020 Nov. PMID 32990380, Free PMC Article
    2. Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Knights AJ, et al. Nat Commun, 2020 Jun 10. PMID 32523103, Free PMC Article
    3. Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor. Burdach J, et al. Nucleic Acids Res, 2014 Jan. PMID 24106088, Free PMC Article
    4. Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81. Kirberg J, et al. Mol Immunol, 2005 Jun. PMID 15829312
    5. Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells. Crossley M, et al. Mol Cell Biol, 1996 Apr. PMID 8657145, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway.
      Title: KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway.
    2. miR-324-5p promotes adipocyte differentiation and lipid droplet accumulation by targeting Krueppel-like factor 3 (KLF3).
      Title: miR-324-5p promotes adipocyte differentiation and lipid droplet accumulation by targeting Krueppel-like factor 3 (KLF3).
    3. Kruppel-like factor 3 (KLF3) suppresses NF-kappaB-driven inflammation in mice.
      Title: Krüppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice.
    4. KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells.
      Title: KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells.
    5. miR-20a-5p promotes adipocyte differentiation from bone marrow-derived stromal cells by targeting and negatively regulating Klf3 in the early phase during the procedure of adipogenesis.
      Title: miR-20a-5p promotes adipogenic differentiation of murine bone marrow stromal cells via targeting Kruppel-like factor 3.
    6. KLF1 and KLF3 bind common as well as unique sites within the erythroid cell genome.
      Title: Krüppel-like factors compete for promoters and enhancers to fine-tune transcription.
    7. mechanistic insights into the regulation of Lgals3, demonstrating that C-terminal binding protein (CtBP) is required to drive optimal KLF3-mediated silencing.
      Title: Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).
    8. Cineromycin B inhibited adipocyte differentiation in 3T3-L1 cells mainly via upregulation of KLF2 and KLF3 mRNA expression at an early stage of the differentiation.
      Title: Cineromycin B isolated from Streptomyces cinerochromogenes inhibits adipocyte differentiation of 3T3-L1 cells via Krüppel-like factors 2 and 3.
    9. Phosphorylation of KLF3 and CtBP2 by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3.
      Title: Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.
    10. KLF3 acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation.
      Title: Leukocyte β7 integrin targeted by Krüppel-like factors.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151315

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 3
    Names
    CACCC-box-binding protein BKLF
    Kruppel-like factor 3 (basic)
    basic krueppel-like factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008453.6 → NP_032479.1  Krueppel-like factor 3

      See identical proteins and their annotated locations for NP_032479.1

      Status: VALIDATED

      Source sequence(s)
      AC130535
      Consensus CDS
      CCDS19301.1
      UniProtKB/Swiss-Prot
      Q60980
      UniProtKB/TrEMBL
      Q545J5
      Related
      ENSMUSP00000129363.2, ENSMUST00000165536.8
      Conserved Domains (4) summary
      sd00017
      Location:261 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain
      cd21577
      Location:49 → 259
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    RNA

    1. NR_165035.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130535

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      64960864..64990246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503751.5 → XP_006503814.1  Krueppel-like factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006503814.1

      UniProtKB/Swiss-Prot
      Q60980
      UniProtKB/TrEMBL
      Q545J5
      Conserved Domains (4) summary
      sd00017
      Location:261 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259 → 283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305 → 330
      zf-H2C2_2; Zinc-finger double domain
      cd21577
      Location:49 → 259
      KLF3_N; N-terminal domain of Kruppel-like factor 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60980.1 GenPept UniProtKB/Swiss-Prot:Q60980

    Gene LinkOut

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