CRIP2 cysteine rich protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CRIP2provided by HGNC
Official Full Name: cysteine rich protein 2provided by HGNC
Primary source: HGNC:HGNC:2361
See related: Ensembl:ENSG00000182809 MIM:601183; AllianceGenome:HGNC:2361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRIP; CRP2; ESP1
Summary: This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression: Broad expression in heart (RPKM 55.7), lung (RPKM 26.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.33

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (105472945..105480170)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (99720088..99729539)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (105939282..105946507)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.
Title: Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.
APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
Title: APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
Title: HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
High CRP2 expression is associated with breast cancer cell invasion and metastasis.
Title: CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.
Function of avian CRIP2 in smooth muscle differentiation
Title: Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.
CRIP2 expression is down-regulated in ESCC tissues and cell lines.
Title: The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
CRIP2 acts as a transcription repressor of the NF-kappaB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis
Title: Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.
These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2.
Title: ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH15700 (e-PCR)
- UniSTS:79442

SHGC-1100 (e-PCR)
- UniSTS:92793

CRIP2_8273 (e-PCR)
- UniSTS:467618

RH44854 (e-PCR)
- UniSTS:38584

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cysteine-rich protein 2

Names: Cysteine-rich intestinal protein; LIM domain protein ESP1/CRP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270837.2 → NP_001257766.1 cysteine-rich protein 2 isoform 2

See identical proteins and their annotated locations for NP_001257766.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AK300092, AL928654, BC034151, HY161884

Consensus CDS

CCDS59246.1

UniProtKB/Swiss-Prot

P52943

Related

ENSP00000426119.2, ENST00000483017.7

Conserved Domains (2) summary

cd09401
Location:200 → 253

LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)

cl02475
Location:89 → 132

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001270841.2 → NP_001257770.1 cysteine-rich protein 2 isoform 3

See identical proteins and their annotated locations for NP_001257770.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks multiple exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AL928654, BC034151, BQ684851

UniProtKB/TrEMBL

H0YHD8

Related

ENSP00000446875.1, ENST00000550577.5

Conserved Domains (1) summary

cd09476
Location:5 → 58

LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
NM_001312.4 → NP_001303.1 cysteine-rich protein 2 isoform 1

See identical proteins and their annotated locations for NP_001303.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

BC034151

Consensus CDS

CCDS10003.1

UniProtKB/Swiss-Prot

A1A4U1, B7Z6C0, E9PD13, P52943

UniProtKB/TrEMBL

Q53FN1

Related

ENSP00000328521.5, ENST00000329146.9

Conserved Domains (1) summary

cd09476
Location:5 → 58

LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

RNA

NR_073081.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL928654, BC034151, HY078632
NR_073082.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AL928654, BC034151, BE271979, HY161884
NR_073083.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, compared to variant 1.

Source sequence(s)

BC034151, CN367966

Related

ENST00000538259.2
NR_073084.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AK091845, AW173606

Related

ENST00000548989.5
NR_073085.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AK311402, AL928654, BC034151