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    ZNF7 zinc finger protein 7 [ Homo sapiens (human) ]

    Gene ID: 7553, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF7provided by HGNC
    Official Full Name
    zinc finger protein 7provided by HGNC
    Primary source
    HGNC:HGNC:13139
    See related
    Ensembl:ENSG00000147789 MIM:194531; AllianceGenome:HGNC:13139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX4; zf30; HF.16
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 4.3), endometrium (RPKM 3.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8q24.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144827560..144847508)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (146001303..146021302)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146052945..146072893)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene microRNA 6850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene ribosomal protein L8 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 517 Neighboring gene hESC enhancers GRCh37_chr8:146052597-146053122 and GRCh37_chr8:146053123-146053648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146053649-146054174 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:146076290-146076441 Neighboring gene COMM domain containing 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146077648-146078496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28109 Neighboring gene zinc finger protein 250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126184-146126788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126789-146127391 Neighboring gene uncharacterized LOC124902042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146127392-146127995 Neighboring gene zinc finger protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19717

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma. Esteve-Codina A, et al. Clin Cancer Res, 2021 Jan 15. PMID 33106291
    2. Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. Witte S, et al. J Biol Chem, 1997 Aug 29. PMID 9268371
    3. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Lania L, et al. Genomics, 1990 Feb. PMID 2106481
    4. Computer sequence analysis of human highly conserved zinc finger modules. Petroni D, et al. DNA Seq, 1998. PMID 10520746
    5. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. Malhotra A, et al. Diabetes Metab Res Rev, 2009 Nov. PMID 19795399, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma.
      Title: RNA sequencing and Immunohistochemistry Reveal ZFN7 as a Stronger Marker of Survival than Molecular Subtypes in G-CIMP-negative Glioblastoma.
    2. Single-cell imaging revealed that RIPK3-dependent death caused inflammasome-dependent IL-1beta release from lipopolysaccharide-stimulated A20-deficient macrophages. Importantly, mutation of the A20 ZnF7 ubiquitin binding domain caused arthritis in mice, arguing that ZnF7-dependent inhibition of necroptosis is critical for A20 anti-inflammatory function in vivo.
      Title: A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38706

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 7
    Names
    C2-H2 type zinc finger protein
    Zinc finger protein-7 (KOX4)
    zinc finger protein 7 (KOX 4, clone HF.16)
    zinc finger protein HF.16
    zinc finger protein KOX4
    zinc finger protein zfp30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282795.2 → NP_001269724.1  zinc finger protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001269724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF235103, AK300001
      Consensus CDS
      CCDS64996.1
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000393260.2, ENST00000446747.7
      Conserved Domains (7) summary
      PHA02693
      Location:54 → 127
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:15 → 76
      KRAB; krueppel associated box
      COG5048
      Location:229 → 686
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:592 → 614
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:15 → 52
      KRAB; KRAB box
      pfam13465
      Location:360 → 384
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001282796.2 → NP_001269725.1  zinc finger protein 7 isoform 3

      See identical proteins and their annotated locations for NP_001269725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' terminal exon compared to variant 1. The enocded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF235103, AI862153, AK096025
      Consensus CDS
      CCDS64998.1
      UniProtKB/Swiss-Prot
      P17097
      Related
      ENSP00000435252.1, ENST00000525266.5
      Conserved Domains (3) summary
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam10212
      Location:30 → 129
      TTKRSYEDQ; Predicted coiled-coil domain-containing protein

    3. NM_001282797.2 → NP_001269726.1  zinc finger protein 7 isoform 4

      See identical proteins and their annotated locations for NP_001269726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 6 encode the same protein (isoform 4).
      Source sequence(s)
      AF235103, AK301561, M29580
      Consensus CDS
      CCDS64999.1
      UniProtKB/TrEMBL
      F5H290, Q59F42
      Related
      ENSP00000439424.1, ENST00000544249.2
      Conserved Domains (2) summary
      COG5048
      Location:122 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001330623.1 → NP_001317552.1  zinc finger protein 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF235103, AK300001, DA538365
      Consensus CDS
      CCDS83336.1
      UniProtKB/TrEMBL
      E9PIH3
      Related
      ENSP00000318848.5, ENST00000325217.10

    5. NM_001349805.2 → NP_001336734.1  zinc finger protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, DB554904, DC345768, M29580
      Consensus CDS
      CCDS64999.1
      UniProtKB/TrEMBL
      F5H290, Q59F42
      Conserved Domains (2) summary
      COG5048
      Location:122 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001349806.2 → NP_001336735.1  zinc finger protein 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:21 → 82
      KRAB; krueppel associated box
      COG5048
      Location:235 → 692
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460 → 480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:60 → 133
      PHA02693; hypothetical protein; Provisional

    7. NM_001349807.2 → NP_001336736.1  zinc finger protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, DA926250, DB554904, DC345768, M29580
      Consensus CDS
      CCDS94368.1
      UniProtKB/TrEMBL
      B2R9D8, E9PJX9
      Related
      ENSP00000433656.2, ENST00000527218.6
      Conserved Domains (4) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:217 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:46 → 115
      PHA02693; hypothetical protein; Provisional

    8. NM_001349808.2 → NP_001336737.1  zinc finger protein 7 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, BJ989518, CD617091, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:21 → 81
      KRAB; krueppel associated box
      COG5048
      Location:234 → 691
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:459 → 479
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:63 → 132
      PHA02693; hypothetical protein; Provisional

    9. NM_001349809.2 → NP_001336738.1  zinc finger protein 7 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF235103, BC058923, CT004931, DB554904, DC345768, DC357767, M29580
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (4) summary
      smart00349
      Location:25 → 86
      KRAB; krueppel associated box
      COG5048
      Location:239 → 696
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:64 → 137
      PHA02693; hypothetical protein; Provisional

    10. NM_003416.4 → NP_003407.1  zinc finger protein 7 isoform 2

      See identical proteins and their annotated locations for NP_003407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF235103, BC058923
      Consensus CDS
      CCDS6435.1
      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000432641.2, ENST00000532777.6
      Conserved Domains (7) summary
      PHA02693
      Location:43 → 116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      COG5048
      Location:218 → 675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:349 → 373
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      144827560..144847508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422206.1 → XP_047278162.1  zinc finger protein 7 isoform X7

    2. XM_017013816.3 → XP_016869305.1  zinc finger protein 7 isoform X8

    3. XM_011517294.3 → XP_011515596.1  zinc finger protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011515596.1

      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (7) summary
      PHA02693
      Location:43 → 116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      COG5048
      Location:218 → 675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:349 → 373
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011517292.4 → XP_011515594.1  zinc finger protein 7 isoform X5

      See identical proteins and their annotated locations for XP_011515594.1

      UniProtKB/TrEMBL
      B2R9D8
      Conserved Domains (7) summary
      PHA02693
      Location:54 → 127
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:15 → 76
      KRAB; krueppel associated box
      COG5048
      Location:229 → 686
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:592 → 614
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:15 → 52
      KRAB; KRAB box
      pfam13465
      Location:360 → 384
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011517293.3 → XP_011515595.1  zinc finger protein 7 isoform X1

      See identical proteins and their annotated locations for XP_011515595.1

      UniProtKB/Swiss-Prot
      B4DT08, D3DWN6, P17015, P17097, Q8N8Y4
      UniProtKB/TrEMBL
      B2R9D8
      Related
      ENSP00000432724.1, ENST00000528372.5
      Conserved Domains (7) summary
      PHA02693
      Location:43 → 116
      PHA02693; hypothetical protein; Provisional
      smart00349
      Location:4 → 65
      KRAB; krueppel associated box
      COG5048
      Location:218 → 675
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:349 → 373
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011517296.4 → XP_011515598.1  zinc finger protein 7 isoform X2

      See identical proteins and their annotated locations for XP_011515598.1

      UniProtKB/TrEMBL
      B2R9D8, E9PJX9
      Conserved Domains (4) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:217 → 674
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:442 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl28640
      Location:46 → 115
      PHA02693; hypothetical protein; Provisional

    7. XM_047422204.1 → XP_047278160.1  zinc finger protein 7 isoform X3

    8. XM_006716654.4 → XP_006716717.1  zinc finger protein 7 isoform X6

      See identical proteins and their annotated locations for XP_006716717.1

      UniProtKB/TrEMBL
      F5H290, Q59F42
      Conserved Domains (2) summary
      COG5048
      Location:122 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:347 → 367
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_047422205.1 → XP_047278161.1  zinc finger protein 7 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      146001303..146021302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361194.1 → XP_054217169.1  zinc finger protein 7 isoform X8

    2. XM_054361189.1 → XP_054217164.1  zinc finger protein 7 isoform X3

    3. XM_054361192.1 → XP_054217167.1  zinc finger protein 7 isoform X6

      UniProtKB/TrEMBL
      B4DWJ4

    4. XM_054361186.1 → XP_054217161.1  zinc finger protein 7 isoform X1

    5. XM_054361193.1 → XP_054217168.1  zinc finger protein 7 isoform X7

    6. XM_054361187.1 → XP_054217162.1  zinc finger protein 7 isoform X1

    7. XM_054361188.1 → XP_054217163.1  zinc finger protein 7 isoform X2

    8. XM_054361191.1 → XP_054217166.1  zinc finger protein 7 isoform X5

    9. XM_054361190.1 → XP_054217165.1  zinc finger protein 7 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17097.1 GenPept UniProtKB/Swiss-Prot:P17097

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