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    Sergef secretion regulating guanine nucleotide exchange factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365243, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Sergefprovided by RGD
    Official Full Name
    secretion regulating guanine nucleotide exchange factorprovided by RGD
    Primary source
    RGD:1563497
    See related
    Ensembl:ENSRNOG00000011488 AllianceGenome:RGD:1563497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563497
    Summary
    Predicted to be involved in negative regulation of protein secretion. Predicted to be located in cytosol and nucleoplasm. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 216.6), Kidney (RPKM 73.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sergef in Genome Data Viewer
    Location:
    1q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106085950..106288815, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96949660..97152529, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102461327..102664978, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099806 Neighboring gene myogenic differentiation 1 Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene uncharacterized LOC134485121 Neighboring gene uncharacterized LOC120099808 Neighboring gene tryptophan hydroxylase 1 Neighboring gene serum amyloid A-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. Sjölinder M, et al. FEBS Lett, 2002 Dec 4. PMID 12459492
    2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. Uhlmann J, et al. FEBS Lett, 1999 Oct 22. PMID 10571079
    3. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, et al. Front Genet, 2020. PMID 33381146, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretion-regulating guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400924.1 → NP_001387853.1  secretion-regulating guanine nucleotide exchange factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JBC2, D3ZN16
      Related
      ENSRNOP00000015352.5, ENSRNOT00000015352.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      106085950..106288815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269165.1 → XP_063125235.1  secretion-regulating guanine nucleotide exchange factor isoform X5

    2. XM_039100958.1 → XP_038956886.1  secretion-regulating guanine nucleotide exchange factor isoform X3

      Conserved Domains (1) summary
      COG5184
      Location:17 → 304
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    3. XM_039100961.1 → XP_038956889.1  secretion-regulating guanine nucleotide exchange factor isoform X6

      Conserved Domains (1) summary
      COG5184
      Location:17 → 245
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    4. XM_006229229.4 → XP_006229291.1  secretion-regulating guanine nucleotide exchange factor isoform X7

      See identical proteins and their annotated locations for XP_006229291.1

      UniProtKB/TrEMBL
      A0A8I6AL11
      Conserved Domains (2) summary
      pfam00415
      Location:17 → 64
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:103 → 132
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    5. XM_039100959.1 → XP_038956887.1  secretion-regulating guanine nucleotide exchange factor isoform X4

      Related
      ENSRNOP00000093927.1, ENSRNOT00000097997.1
      Conserved Domains (1) summary
      COG5184
      Location:17 → 298
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    6. XM_039100957.1 → XP_038956885.1  secretion-regulating guanine nucleotide exchange factor isoform X1

      Conserved Domains (1) summary
      COG5184
      Location:17 → 325
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    7. XM_006229227.4 → XP_006229289.1  secretion-regulating guanine nucleotide exchange factor isoform X2

      See identical proteins and their annotated locations for XP_006229289.1

      UniProtKB/TrEMBL
      A0A8I6AL11
      Conserved Domains (2) summary
      pfam00415
      Location:17 → 64
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:103 → 132
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    8. XM_063269181.1 → XP_063125251.1  secretion-regulating guanine nucleotide exchange factor isoform X8

    9. XM_063269178.1 → XP_063125248.1  secretion-regulating guanine nucleotide exchange factor isoform X8

    10. XM_039100966.2 → XP_038956894.1  secretion-regulating guanine nucleotide exchange factor isoform X9

      Conserved Domains (1) summary
      COG5184
      Location:17 → 279
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RNA

    1. XR_005499054.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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