KIF3B kinesin family member 3B [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF3Bprovided by HGNC
Official Full Name: kinesin family member 3Bprovided by HGNC
Primary source: HGNC:HGNC:6320
See related: Ensembl:ENSG00000101350 MIM:603754; AllianceGenome:HGNC:6320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLA8; RP89; HH0048; KLP-11; OTSC12
Summary: The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 22.2), kidney (RPKM 21.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (32277651..32335011)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (34001508..34059883)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30865454..30922814)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF3B gene silent variant leading to sperm morphology and motility defects and male infertilitydagger.
Title: KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†.
Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
Title: Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Title: Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
Title: LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Title: Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
miR-127-3p was downregulated in oral squamous cell carcinoma (OSCC) tissues and was associated with malignant clinicopathological features and poor prognosis. KIF3B was confirmed to be a direct target of miR-127-3p. Upregulation of KIF3B observed in OSCC promoted tumorigenesis. miR-127-3p targeted KIF3B to inhibit the development of OSCC by suppressing cell proliferation, migration and invasion.
Title: MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia.
Title: Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.
High KIF3B expression is associated with Pancreatic Cancer.
Title: KIF3B Promotes the Proliferation of Pancreatic Cancer.
The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport.
Title: Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.
High KIF3B expression is associated with seminoma.
Title: A novel role of KIF3b in the seminoma cell cycle.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Retinitis pigmentosa 89 MedGen: C5394552 OMIM: 618955 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-81319 (e-PCR)
- UniSTS:102684

A002Q37 (e-PCR)
- UniSTS:26945

IB1791 (e-PCR)
- UniSTS:56425

G63577 (e-PCR)
- UniSTS:140688

A002U20 (e-PCR)
- UniSTS:41646

RH12366 (e-PCR)
- UniSTS:24249

D20S582E (e-PCR)
- UniSTS:48576

D20S555E (e-PCR)
- UniSTS:4829

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables intraciliary transport particle B binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	TAS Traceable Author Statement more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	TAS Traceable Author Statement more info	PubMed
involved_in intraciliary transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic centrosome separation	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	TAS Traceable Author Statement more info	PubMed
involved_in opsin transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plus-end-directed vesicle transport along microtubule	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in centrosome	NAS Non-traceable Author Statement more info	PubMed
located_in ciliary tip	TAS Traceable Author Statement more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
part_of kinesin II complex	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
part_of plus-end kinesin complex	TAS Traceable Author Statement more info	PubMed
colocalizes_with spindle microtubule	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF3B

Names: microtubule plus end-directed kinesin motor 3B

NP_004789.1

EC 5.6.1.3

XP_047296545.1

EC 5.6.1.3

XP_047296546.1

EC 5.6.1.3

XP_054180203.1

EC 5.6.1.3

XP_054180204.1

EC 5.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004798.4 → NP_004789.1 kinesin-like protein KIF3B

See identical proteins and their annotated locations for NP_004789.1

Status: REVIEWED

Source sequence(s)

AB002357, AL121897, AL353976, AL354800, BC136311, DA805755

Consensus CDS

CCDS13200.1

UniProtKB/Swiss-Prot

B2RMP4, B4DSR5, E1P5M5, O15066

Related

ENSP00000364864.3, ENST00000375712.4

Conserved Domains (2) summary

COG1196
Location:352 → 614

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01371
Location:8 → 340

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins