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    Cep97 centrosomal protein 97 [ Mus musculus (house mouse) ]

    Gene ID: 74201, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cep97provided by MGI
    Official Full Name
    centrosomal protein 97provided by MGI
    Primary source
    MGI:MGI:1921451
    See related
    Ensembl:ENSMUSG00000022604 AllianceGenome:MGI:1921451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrriq2; 2810403B08Rik; 4932439K18Rik; E130116N02Rik
    Summary
    Involved in negative regulation of cilium assembly. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including intestine; male reproductive gland or organ; nervous system; thymus; and urinary system. Orthologous to human CEP97 (centrosomal protein 97). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 3.3), CNS E11.5 (RPKM 2.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C1.1; 16 33.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55720250..55755237, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55899888..55934848, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7464 Neighboring gene STARR-positive B cell enhancer ABC_E7465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:55949146-55949379 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4179 Neighboring gene STARR-seq mESC enhancer starr_41049 Neighboring gene STARR-seq mESC enhancer starr_41050 Neighboring gene predicted gene 6958

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. Song T, et al. EMBO Rep, 2022 May 4. PMID 35301795, Free PMC Article
    2. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Huang N, et al. Nat Commun, 2018 Oct 30. PMID 30375385, Free PMC Article
    3. Cep97 and CP110 suppress a cilia assembly program. Spektor A, et al. Cell, 2007 Aug 24. PMID 17719545
    4. Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice. Ding W, et al. Sci China Life Sci, 2021 Mar. PMID 32803714
    5. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
      Title: ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cilium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein of 97 kDa
    Names
    leucine-rich repeat and IQ domain-containing protein 2
    leucine-rich repeats and IQ motif containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159364.1 → NP_001152836.1  centrosomal protein of 97 kDa isoform 2

      See identical proteins and their annotated locations for NP_001152836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC065773, BC067049
      Consensus CDS
      CCDS49871.1
      UniProtKB/TrEMBL
      Q6P077
      Related
      ENSMUSP00000113009.2, ENSMUST00000122280.8
      Conserved Domains (3) summary
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:103 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:80 → 136
      LRR_8; Leucine rich repeat

    2. NM_001159365.1 → NP_001152837.1  centrosomal protein of 97 kDa isoform 3

      See identical proteins and their annotated locations for NP_001152837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK079884, BC065773, BC067049
      Consensus CDS
      CCDS49873.1
      UniProtKB/TrEMBL
      Q8BH46
      Related
      ENSMUSP00000112502.2, ENSMUST00000121129.8
      Conserved Domains (3) summary
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:103 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:80 → 136
      LRR_8; Leucine rich repeat

    3. NM_001159366.1 → NP_001152838.1  centrosomal protein of 97 kDa isoform 4

      See identical proteins and their annotated locations for NP_001152838.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK080249, BC065773, BC067049
      Consensus CDS
      CCDS49872.1
      UniProtKB/TrEMBL
      Q8BJR7
      Related
      ENSMUSP00000113470.3, ENSMUST00000121703.3
      Conserved Domains (3) summary
      sd00033
      Location:40 → 59
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:103 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:80 → 136
      LRR_8; Leucine rich repeat

    4. NM_028815.4 → NP_083091.1  centrosomal protein of 97 kDa isoform 1

      See identical proteins and their annotated locations for NP_083091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC165151, AC171202, BC067049
      Consensus CDS
      CCDS28217.1
      UniProtKB/Swiss-Prot
      Q8BL35, Q9CZ62
      Related
      ENSMUSP00000023270.8, ENSMUST00000023270.14
      Conserved Domains (3) summary
      sd00033
      Location:17 → 37
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:103 → 144
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:80 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      55720250..55755237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939252.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ62.1 GenPept UniProtKB/Swiss-Prot:Q9CZ62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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