SP140 SP140 nuclear body protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: SP140provided by HGNC
Official Full Name: SP140 nuclear body proteinprovided by HGNC
Primary source: HGNC:HGNC:17133
See related: Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LYSP100; LYSP100-A; LYSP100-B
Summary: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Expression: Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more
Orthologs: all
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Genomic context

Location:: 2q37.1

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (230186151..230316571)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (230669263..230808985)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (231090451..231177930)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SP140 inhibits STAT1 signaling, induces IFN-gamma in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
Title: SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
Title: Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
Title: Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases.
The Sp140 is multi-SUMOylated and its PHD finger works as versatile protein-protein interaction platform promoting intramolecular SUMOylation of the adjacent BRD.
Title: Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.
Our findings showed that SP140 is an important repressor of genes implicated in inflammation, suggesting that decreased expression of SP140, promoted by the rs28445040-T risk variant, may lead to up-regulation of these genes by means of NF-kappaB inhibition in B cells.
Title: SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition.
IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
Title: Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.
Data identified rs28445040 variant in SP140 gene as the causal factor for skipping of exon 7 and the most associated with multiple sclerosis.
Title: A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.
the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif
Title: Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	Wild-type HIV-1 Vif binds to the carboxyl-terminal region of Sp140 between amino acids 527-836, while Vif mutants with deletions of amino acids 12-23, 43-59, 73-87 or 97-112 are strongly inhibited in their binding to Sp140	PubMed
	vif	HIV-1 Vif may enhance the cytosolic retention of Sp140	PubMed
	vif	Specific binding of HIV-1 Vif to Sp140 was identified using a yeast two-hybrid screen of a human lymphocyte cDNA library and verified by co-immunoprecipitation	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S172 (e-PCR)
- UniSTS:46623

SHGC-34902 (e-PCR)
- UniSTS:60450

D2S172 (e-PCR)
- UniSTS:11070

SHGC-401 (e-PCR)
- UniSTS:89459

RH18044 (e-PCR)
- UniSTS:4588

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in mitochondrion	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear body protein SP140

Names: lymphoid-restricted homolog of Sp100; lymphoid-specific SP100 homolog; nuclear autoantigen Sp-140; speckled 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051286.2 RefSeqGene

Range

44587..132066

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001005176.3 → NP_001005176.1 nuclear body protein SP140 isoform 2

See identical proteins and their annotated locations for NP_001005176.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons, and has an alternate 3' sequence, as compared to variant 1. The encoded isoform 2 is much shorter and has a distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AA741304, AK301267, BC070160

Consensus CDS

CCDS33392.1

UniProtKB/Swiss-Prot

Q13342

UniProtKB/TrEMBL

B4DVW8

Related

ENSP00000362749.3, ENST00000373645.3

Conserved Domains (1) summary

pfam03172
Location:42 → 135

Sp100; Sp100 domain
NM_001278451.2 → NP_001265380.1 nuclear body protein SP140 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC009949, BC105960, DC391925, U36499

Consensus CDS

CCDS63150.1

UniProtKB/TrEMBL

Q0VGE4

Related

ENSP00000398210.3, ENST00000420434.7

Conserved Domains (4) summary

cd05501
Location:730 → 833

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:665 → 706

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:558 → 633

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
NM_001278452.2 → NP_001265381.1 nuclear body protein SP140 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC009949, BC105744, DC391925, U36499

Consensus CDS

CCDS63151.1

UniProtKB/TrEMBL

Q0VGE4

Related

ENSP00000342096.6, ENST00000343805.10

Conserved Domains (5) summary

cd05501
Location:697 → 800

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

PHA03169
Location:202 → 419

PHA03169; hypothetical protein; Provisional

cd15626
Location:632 → 673

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:525 → 600

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
NM_001278453.2 → NP_001265382.1 nuclear body protein SP140 isoform 5

See identical proteins and their annotated locations for NP_001265382.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC009949, AC009950, DC391925, U36499, U63420

Consensus CDS

CCDS63149.1

UniProtKB/TrEMBL

Q0VGE4

Related

ENSP00000393618.3, ENST00000417495.7

Conserved Domains (4) summary

cd05501
Location:643 → 746

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:578 → 619

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:471 → 546

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
NM_007237.5 → NP_009168.4 nuclear body protein SP140 isoform 1

See identical proteins and their annotated locations for NP_009168.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC009949, AK301267, BC038091, BC105960, U36500

Consensus CDS

CCDS42831.1

UniProtKB/Swiss-Prot

E7ESH9, E7EUR5, E9PFJ6, Q0VGE5, Q13341, Q13342, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4, Q92881, Q96TG3

UniProtKB/TrEMBL

Q0VGE4

Related

ENSP00000375899.3, ENST00000392045.8

Conserved Domains (4) summary

cd05501
Location:757 → 860

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:692 → 733

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:585 → 660

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

230186151..230316571

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443073.1 → XP_047299029.1 nuclear body protein SP140 isoform X7
XM_011510517.4 → XP_011508819.1 nuclear body protein SP140 isoform X7

See identical proteins and their annotated locations for XP_011508819.1

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:737 → 840

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:672 → 713

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:565 → 640

SAND; SAND domain

pfam03172
Location:22 → 115

Sp100; Sp100 domain
XM_006712223.4 → XP_006712286.1 nuclear body protein SP140 isoform X1

UniProtKB/TrEMBL

B4DVW8

Conserved Domains (4) summary

cd15626
Location:692 → 733

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:585 → 660

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain

cl02556
Location:757 → 838

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
XM_047443077.1 → XP_047299033.1 nuclear body protein SP140 isoform X21
XM_011510518.3 → XP_011508820.1 nuclear body protein SP140 isoform X7

See identical proteins and their annotated locations for XP_011508820.1

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:737 → 840

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:672 → 713

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:565 → 640

SAND; SAND domain

pfam03172
Location:22 → 115

Sp100; Sp100 domain
XM_011510516.2 → XP_011508818.1 nuclear body protein SP140 isoform X5

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:748 → 851

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:692 → 726

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:585 → 660

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_011510515.2 → XP_011508817.1 nuclear body protein SP140 isoform X3

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:751 → 854

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:686 → 727

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:579 → 654

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_005246254.3 → XP_005246311.1 nuclear body protein SP140 isoform X13

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:723 → 826

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:658 → 699

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:551 → 626

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_011510519.2 → XP_011508821.1 nuclear body protein SP140 isoform X9

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:730 → 833

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:665 → 706

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:558 → 633

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_005246256.3 → XP_005246313.1 nuclear body protein SP140 isoform X20

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:696 → 799

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:631 → 672

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:524 → 599

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_047443078.1 → XP_047299034.1 nuclear body protein SP140 isoform X24
XM_005246255.3 → XP_005246312.1 nuclear body protein SP140 isoform X16

UniProtKB/TrEMBL

B4DVW8

Conserved Domains (4) summary

cd05501
Location:707 → 810

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:642 → 683

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:535 → 610

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_047443076.1 → XP_047299032.1 nuclear body protein SP140 isoform X19
XM_017003252.2 → XP_016858741.1 nuclear body protein SP140 isoform X28

UniProtKB/TrEMBL

Q0VGE4
XM_005246253.3 → XP_005246310.1 nuclear body protein SP140 isoform X8

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (5) summary

cd05501
Location:731 → 834

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

PHA03169
Location:202 → 453

PHA03169; hypothetical protein; Provisional

cd15626
Location:666 → 707

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:559 → 634

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_017003240.2 → XP_016858729.1 nuclear body protein SP140 isoform X12

UniProtKB/TrEMBL

Q0VGE4
XM_017003249.2 → XP_016858738.1 nuclear body protein SP140 isoform X26

UniProtKB/TrEMBL

Q0VGE4
XM_005246252.3 → XP_005246309.1 nuclear body protein SP140 isoform X2

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:754 → 857

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:689 → 730

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:582 → 657

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_047443072.1 → XP_047299028.1 nuclear body protein SP140 isoform X6
XM_017003239.2 → XP_016858728.1 nuclear body protein SP140 isoform X4

UniProtKB/TrEMBL

Q0VGE4
XM_017003243.2 → XP_016858732.1 nuclear body protein SP140 isoform X15

UniProtKB/TrEMBL

Q0VGE4
XM_047443074.1 → XP_047299030.1 nuclear body protein SP140 isoform X11
XM_017003248.2 → XP_016858737.1 nuclear body protein SP140 isoform X23

UniProtKB/TrEMBL

Q0VGE4
XM_047443079.1 → XP_047299035.1 nuclear body protein SP140 isoform X25
XM_017003245.2 → XP_016858734.1 nuclear body protein SP140 isoform X17

UniProtKB/TrEMBL

B4DVW8
XM_011510520.2 → XP_011508822.1 nuclear body protein SP140 isoform X10

UniProtKB/TrEMBL

Q0VGE4

Conserved Domains (4) summary

cd05501
Location:728 → 831

Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...

cd15626
Location:663 → 704

PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components

pfam01342
Location:556 → 631

SAND; SAND domain

pfam03172
Location:42 → 135

Sp100; Sp100 domain
XM_017003242.2 → XP_016858731.1 nuclear body protein SP140 isoform X14

UniProtKB/TrEMBL

Q0VGE4
XM_017003247.2 → XP_016858736.1 nuclear body protein SP140 isoform X22

UniProtKB/TrEMBL

Q0VGE4
XM_017003246.2 → XP_016858735.1 nuclear body protein SP140 isoform X18

UniProtKB/TrEMBL

Q0VGE4
XM_017003250.2 → XP_016858739.1 nuclear body protein SP140 isoform X27

UniProtKB/TrEMBL

Q0VGE4
XM_047443080.1 → XP_047299036.1 nuclear body protein SP140 isoform X29
XM_047443081.1 → XP_047299037.1 nuclear body protein SP140 isoform X31
XM_017003253.2 → XP_016858742.1 nuclear body protein SP140 isoform X30