Nrg1 neuregulin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrg1provided by MGI
Official Full Name: neuregulin 1provided by MGI
Primary source: MGI:MGI:96083
See related: Ensembl:ENSMUSG00000062991 AllianceGenome:MGI:96083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GGF; HRG; Hgl; NDF; ARIA; SMDF; GGFII; HRGalpha; Pro-NRG1; 6030402G23Rik; D230005F13Rik
Summary: Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 2.0), CNS E14 (RPKM 1.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A3; 8 18.75 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (32299493..33381858, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (31807452..32891609, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.
Title: Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium.
Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.
Title: Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.
Parvalbumin interneurons dysfunction is potentially associated with FalphaMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
Title: Parvalbumin interneurons dysfunction is potentially associated with FαMNs decrease and NRG1-ErbB4 signaling inhibition in spinal cord in amyotrophic lateral sclerosis.
Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.
Title: Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in Ventricular Development.
Compensatory role of neuregulin-1 in diabetic cardiomyopathy.
Title: Compensatory role of neuregulin-1 in diabetic cardiomyopathy.
Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation.
Title: Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation.
Involvement of CXCL10 in Neuronal Damage under the Condition of Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1.
Title: Involvement of CXCL10 in Neuronal Damage under the Condition of Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1.
Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1.
Title: Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1.
Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease.
Title: Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease.
Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia.
Title: Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia.

Submit: New GeneRIF Correction See all GeneRIFs (208)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4) 1 citation
Targeted (16) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nrg1 (e-PCR), detects polymorphism
- UniSTS:468009

UniSTS:468010 (e-PCR)
- UniSTS:468010

Nrg1 (e-PCR), detects polymorphism
- UniSTS:468010

NoName (e-PCR)
- UniSTS:548407

NoName (e-PCR)
- UniSTS:548408

PMC15205P1 (e-PCR)
- UniSTS:271199

D16Wox14 (e-PCR)
- UniSTS:518551

NRG1 (e-PCR)
- UniSTS:479995

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ErbB-2 class receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables ErbB-2 class receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
enables ErbB-3 class receptor binding	ISO Inferred from Sequence Orthology more info
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemorepellent activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info	PubMed
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in ERBB signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB2-ERBB3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ERBB2-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ERBB4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in ERBB4-ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Schwann cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Schwann cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac conduction system development	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination in peripheral nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of secretion	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of metal ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic membrane adhesion	EXP Inferred from Experiment more info	PubMed
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mossy fiber rosette	EXP Inferred from Experiment more info	PubMed
is_active_in mossy fiber rosette	IDA Inferred from Direct Assay more info	PubMed
is_active_in mossy fiber rosette	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pro-neuregulin-1, membrane-bound isoform

Names: heregulin; type I neuregulin 1; type III neuregulin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364421.2 → NP_001351350.1 pro-neuregulin-1, membrane-bound isoform isoform 2

Status: VALIDATED

Source sequence(s)

AC127374, AC132407, AC136147

Consensus CDS

CCDS90385.1

UniProtKB/Swiss-Prot

Q6DR98

UniProtKB/TrEMBL

A0A140LJ88

Related

ENSMUSP00000146456.2, ENSMUST00000207470.3

Conserved Domains (3) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:240 → 633

Neuregulin; Neuregulin family
NM_001364422.1 → NP_001351351.1 pro-neuregulin-1, membrane-bound isoform isoform 3

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

Conserved Domains (1) summary

pfam02158
Location:287 → 680

Neuregulin; Neuregulin family
NM_001364423.1 → NP_001351352.1 pro-neuregulin-1, membrane-bound isoform isoform 4

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

Conserved Domains (2) summary

pfam00008
Location:245 → 275

EGF; EGF-like domain

pfam02158
Location:353 → 708

Neuregulin; Neuregulin family
NM_001364424.1 → NP_001351353.1 pro-neuregulin-1, membrane-bound isoform isoform 5

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

UniProtKB/TrEMBL

Q3URY7

Conserved Domains (1) summary

pfam02158
Location:295 → 484

Neuregulin; Neuregulin family
NM_001364425.1 → NP_001351354.1 pro-neuregulin-1, membrane-bound isoform isoform 6

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

Conserved Domains (1) summary

pfam02158
Location:75 → 430

Neuregulin; Neuregulin family
NM_001364426.1 → NP_001351355.1 pro-neuregulin-1, membrane-bound isoform isoform 7

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

Consensus CDS

CCDS90383.1

UniProtKB/TrEMBL

A0A140LIG9, Q3URY7

Related

ENSMUSP00000146816.2, ENSMUST00000208497.3

Conserved Domains (1) summary

pfam02158
Location:295 → 483

Neuregulin; Neuregulin family
NM_001364427.1 → NP_001351356.1 pro-neuregulin-1, membrane-bound isoform isoform 8

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

UniProtKB/TrEMBL

Q3URY7

Conserved Domains (1) summary

pfam02158
Location:321 → 510

Neuregulin; Neuregulin family
NM_001364428.1 → NP_001351357.1 pro-neuregulin-1, membrane-bound isoform isoform 9

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

UniProtKB/TrEMBL

Q3URY7

Conserved Domains (1) summary

pfam02158
Location:287 → 476

Neuregulin; Neuregulin family
NM_001364429.1 → NP_001351358.1 pro-neuregulin-1, membrane-bound isoform isoform 10 precursor

Status: VALIDATED

Source sequence(s)

AC127374, AC132407

UniProtKB/TrEMBL

Q3TD94

Related

ENSMUSP00000159071.2, ENSMUST00000207678.3

Conserved Domains (2) summary

pfam00008
Location:78 → 108

EGF; EGF-like domain

pfam02158
Location:123 → 311

Neuregulin; Neuregulin family
NM_001364430.1 → NP_001351359.1 pro-neuregulin-1, membrane-bound isoform isoform 11 precursor

Status: VALIDATED

Source sequence(s)

AC132407
NM_001364431.1 → NP_001351360.1 pro-neuregulin-1, membrane-bound isoform isoform 12

Status: VALIDATED

Source sequence(s)

AC132407, AK048708

Consensus CDS

CCDS90382.1

UniProtKB/TrEMBL

A0A5F8MPT0, Q8BX76

Related

ENSMUSP00000159096.2, ENSMUST00000238812.2

Conserved Domains (1) summary

cl28647
Location:236 → 279

PHA02887; EGF-like protein; Provisional
NM_178591.3 → NP_848706.2 pro-neuregulin-1, membrane-bound isoform isoform 1

See identical proteins and their annotated locations for NP_848706.2

Status: VALIDATED

Source sequence(s)

AC127374, AC132407, AK141037, AY648975, BY238526

Consensus CDS

CCDS40315.1

UniProtKB/TrEMBL

Q6DR99

Related

ENSMUSP00000073546.5, ENSMUST00000073884.7

Conserved Domains (2) summary

PHA02887
Location:236 → 279

PHA02887; EGF-like protein; Provisional

pfam02158
Location:295 → 688

Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

32299493..33381858 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509068.5 → XP_006509131.1 pro-neuregulin-1, membrane-bound isoform isoform X10

Conserved Domains (4) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

PHA03099
Location:361 → 450

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:369 → 399

EGF; EGF-like domain

pfam02158
Location:443 → 798

Neuregulin; Neuregulin family
XM_006509067.5 → XP_006509130.1 pro-neuregulin-1, membrane-bound isoform isoform X9

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:369 → 399

EGF; EGF-like domain

pfam02158
Location:451 → 806

Neuregulin; Neuregulin family
XM_006509065.5 → XP_006509128.1 pro-neuregulin-1, membrane-bound isoform isoform X7

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:369 → 399

EGF; EGF-like domain

pfam02158
Location:477 → 832

Neuregulin; Neuregulin family
XM_006509066.5 → XP_006509129.1 pro-neuregulin-1, membrane-bound isoform isoform X8

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:386 → 416

EGF; EGF-like domain

pfam02158
Location:468 → 823

Neuregulin; Neuregulin family
XM_006509061.5 → XP_006509124.1 pro-neuregulin-1, membrane-bound isoform isoform X3

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:386 → 416

EGF; EGF-like domain

pfam02158
Location:494 → 849

Neuregulin; Neuregulin family
XM_006509064.5 → XP_006509127.1 pro-neuregulin-1, membrane-bound isoform isoform X6

Conserved Domains (4) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

PHA03099
Location:395 → 484

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:477 → 832

Neuregulin; Neuregulin family
XM_006509062.5 → XP_006509125.1 pro-neuregulin-1, membrane-bound isoform isoform X4

UniProtKB/TrEMBL

A0A140LHZ9

Related

ENSMUSP00000146617.3, ENSMUST00000209107.4

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:485 → 840

Neuregulin; Neuregulin family
XM_006509060.5 → XP_006509123.1 pro-neuregulin-1, membrane-bound isoform isoform X2

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:503 → 858

Neuregulin; Neuregulin family
XM_006509059.5 → XP_006509122.1 pro-neuregulin-1, membrane-bound isoform isoform X1

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:511 → 866

Neuregulin; Neuregulin family
XM_006509063.5 → XP_006509126.1 pro-neuregulin-1, membrane-bound isoform isoform X5

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:480 → 835

Neuregulin; Neuregulin family
XM_030243394.1 → XP_030099254.1 pro-neuregulin-1, membrane-bound isoform isoform X18

UniProtKB/TrEMBL

A0A5F8MPJ0

Conserved Domains (3) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:156 → 186

EGF; EGF-like domain

pfam02158
Location:264 → 619

Neuregulin; Neuregulin family
XM_030243393.2 → XP_030099253.1 pro-neuregulin-1, membrane-bound isoform isoform X16

UniProtKB/TrEMBL

A0A140LJ88, A0A140LJC1

Related

ENSMUSP00000147156.2, ENSMUST00000208205.3

Conserved Domains (4) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

PHA03099
Location:182 → 274

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:267 → 622

Neuregulin; Neuregulin family
XM_006509078.5 → XP_006509141.1 pro-neuregulin-1, membrane-bound isoform isoform X15

UniProtKB/TrEMBL

A0A140LJ88

Related

ENSMUSP00000147121.2, ENSMUST00000208488.2

Conserved Domains (3) summary

cd05895
Location:53 → 127

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:298 → 653

Neuregulin; Neuregulin family
XM_036153857.1 → XP_036009750.1 pro-neuregulin-1, membrane-bound isoform isoform X17

UniProtKB/TrEMBL

A0A140LIP8, A0A140LJ88

Related

ENSMUSP00000146905.2, ENSMUST00000207417.3

Conserved Domains (4) summary

PHA03099
Location:182 → 271

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam00008
Location:190 → 220

EGF; EGF-like domain

pfam02158
Location:264 → 619

Neuregulin; Neuregulin family

cd05895
Location:37 → 129

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
XM_006509072.4 → XP_006509135.1 pro-neuregulin-1, membrane-bound isoform isoform X12

UniProtKB/TrEMBL

A0A5F8MPT8

Related

ENSMUSP00000159112.2, ENSMUST00000238842.2

Conserved Domains (2) summary

pfam00008
Location:245 → 275

EGF; EGF-like domain

pfam02158
Location:322 → 677

Neuregulin; Neuregulin family
XM_036153856.1 → XP_036009749.1 pro-neuregulin-1, membrane-bound isoform isoform X11

Conserved Domains (2) summary

pfam00008
Location:245 → 275

EGF; EGF-like domain

pfam02158
Location:353 → 708

Neuregulin; Neuregulin family
XM_036153858.1 → XP_036009751.1 pro-neuregulin-1, membrane-bound isoform isoform X23

Conserved Domains (1) summary

pfam02158
Location:9 → 364

Neuregulin; Neuregulin family
XM_036153859.1 → XP_036009752.1 pro-neuregulin-1, membrane-bound isoform isoform X23

Conserved Domains (1) summary

pfam02158
Location:9 → 364

Neuregulin; Neuregulin family
XM_017312640.3 → XP_017168129.1 pro-neuregulin-1, membrane-bound isoform isoform X20

Conserved Domains (1) summary

pfam02158
Location:75 → 430

Neuregulin; Neuregulin family
XM_036153860.1 → XP_036009753.1 pro-neuregulin-1, membrane-bound isoform isoform X23

Conserved Domains (1) summary

pfam02158
Location:9 → 364

Neuregulin; Neuregulin family
XM_017312641.1 → XP_017168130.1 pro-neuregulin-1, membrane-bound isoform isoform X22

Conserved Domains (1) summary

pfam02158
Location:39 → 394

Neuregulin; Neuregulin family
XM_011242133.1 → XP_011240435.1 pro-neuregulin-1, membrane-bound isoform isoform X21

Conserved Domains (1) summary

pfam02158
Location:73 → 428

Neuregulin; Neuregulin family
XM_006509077.5 → XP_006509140.1 pro-neuregulin-1, membrane-bound isoform isoform X14

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

PHA03099
Location:395 → 484

PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

pfam02158
Location:477 → 634

Neuregulin; Neuregulin family
XM_006509076.5 → XP_006509139.1 pro-neuregulin-1, membrane-bound isoform isoform X13

Conserved Domains (3) summary

cd05895
Location:266 → 340

Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

pfam00008
Location:403 → 433

EGF; EGF-like domain

pfam02158
Location:480 → 637

Neuregulin; Neuregulin family
XM_006509081.4 → XP_006509144.1 pro-neuregulin-1, membrane-bound isoform isoform X19

UniProtKB/TrEMBL

Q3URY7

Conserved Domains (2) summary

PHA02887
Location:236 → 278

PHA02887; EGF-like protein; Provisional

pfam02158
Location:322 → 479

Neuregulin; Neuregulin family