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    Dnah7a dynein, axonemal, heavy chain 7A [ Mus musculus (house mouse) ]

    Gene ID: 627872, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Dnah7aprovided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 7Aprovided by MGI
    Primary source
    MGI:MGI:2685838
    See related
    Ensembl:ENSMUSG00000096141 AllianceGenome:MGI:2685838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm992; Dnahc7; Dnahc7a
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in cilium and cytosol. Predicted to be part of inner dynein arm. Is expressed in spermatozoon and testis. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 4.9) and CNS E18 (RPKM 0.2) See more
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    Genomic context

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    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    66
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53436154..53746456, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53396995..53707301, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2543 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene Asnsd1 upstream reading frame Neighboring gene predicted gene, 53553 Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00916 Neighboring gene STARR-seq mESC enhancer starr_00917 Neighboring gene STARR-seq mESC enhancer starr_00918 Neighboring gene STARR-seq mESC enhancer starr_00919 Neighboring gene STARR-seq mESC enhancer starr_00920 Neighboring gene STARR-positive B cell enhancer ABC_E7724 Neighboring gene STARR-seq mESC enhancer starr_00921 Neighboring gene STARR-seq mESC enhancer starr_00924 Neighboring gene predicted gene, 32311 Neighboring gene STARR-positive B cell enhancer ABC_E627 Neighboring gene STARR-positive B cell enhancer ABC_E1544 Neighboring gene STARR-positive B cell enhancer ABC_E3276 Neighboring gene STARR-seq mESC enhancer starr_00925 Neighboring gene serine/threonine kinase 17b (apoptosis-inducing) Neighboring gene STARR-positive B cell enhancer ABC_E7726 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 7681

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. Dong F, et al. J Cell Biol, 2014 Jan 20. PMID 24421334, Free PMC Article
    2. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein, axonemal, heavy chain 7A
    Names
    dynein, axonemal, heavy chain 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252070.1 → NP_001238999.1  dynein, axonemal, heavy chain 7A

      Status: PROVISIONAL

      Source sequence(s)
      AC100561, AC122925, AC138328, AC153650, AK038423
      Consensus CDS
      CCDS56629.1
      UniProtKB/TrEMBL
      E9Q0T8, L7N1Y0
      Related
      ENSMUSP00000092571.6, ENSMUST00000094964.7
      Conserved Domains (6) summary
      pfam03028
      Location:3318 → 4012
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:759 → 1163
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2587 → 2933
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2963 → 3178
      AAA_9; ATP-binding dynein motor region D5
      cl02488
      Location:576 → 764
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl21455
      Location:1290 → 1520
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      53436154..53746456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496179.4 → XP_006496242.1  dynein, axonemal, heavy chain 7A isoform X3

      UniProtKB/TrEMBL
      L7N1Y0
      Conserved Domains (6) summary
      COG5245
      Location:894 → 3688
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:779 → 1184
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1312 → 1638
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2333 → 2593
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2985 → 3201
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3742 → 4042
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_017321900.3 → XP_017177389.1  dynein, axonemal, heavy chain 7A isoform X1

      Conserved Domains (8) summary
      pfam12777
      Location:2609 → 2949
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:779 → 1184
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1312 → 1638
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:1960 → 2140
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:2333 → 2593
      AAA_8; P-loop containing dynein motor region D4
      pfam17852
      Location:1804 → 1951
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam17857
      Location:2174 → 2269
      AAA_lid_1; AAA+ lid domain
      cl38936
      Location:1626 → 1769
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_036152679.1 → XP_036008572.1  dynein, axonemal, heavy chain 7A isoform X2

      Conserved Domains (6) summary
      pfam17857
      Location:2174 → 2233
      AAA_lid_1; AAA+ lid domain
      pfam08393
      Location:779 → 1184
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1312 → 1638
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:1960 → 2140
      AAA_7; P-loop containing dynein motor region D3
      pfam17852
      Location:1804 → 1951
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      cl38936
      Location:1626 → 1769
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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