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    E330034G19Rik RIKEN cDNA E330034G19 gene [ Mus musculus (house mouse) ]

    Gene ID: 105418, updated on 8-Feb-2024

    Summary

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    Official Symbol
    E330034G19Rikprovided by MGI
    Official Full Name
    RIKEN cDNA E330034G19 geneprovided by MGI
    Primary source
    MGI:MGI:2145557
    See related
    Ensembl:ENSMUSG00000121465 AllianceGenome:MGI:2145557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zpac
    Summary
    Acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Is expressed in oocyte and ovary. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.8) and ovary adult (RPKM 0.8) See more
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    Genomic context

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    Location:
    14 A3; 14 14.33 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (24343282..24360028)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (24293214..24309960)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene predicted gene, 52143 Neighboring gene STARR-seq mESC enhancer starr_36186 Neighboring gene VISTA enhancer mm1485 Neighboring gene STARR-seq mESC enhancer starr_36187 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide A pseudogene Neighboring gene STARR-seq mESC enhancer starr_36189 Neighboring gene STARR-seq mESC enhancer starr_36191 Neighboring gene cysteine rich protein 2 pseudogene Neighboring gene predicted gene, 41108

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZPAC is required for normal spermatogenesis in mice. Zuo EW, et al. Mol Reprod Dev, 2015 Oct. PMID 26153379
    2. Possible role of ZPAC, zygote-specific proteasome assembly chaperone, during spermatogenesis in the mouse. Shimizu N, et al. J Reprod Dev, 2014. PMID 24583807, Free PMC Article
    3. Mouse zygote-specific proteasome assembly chaperone important for maternal-to-zygotic transition. Shin SW, et al. Biol Open, 2013 Feb 15. PMID 23429752, Free PMC Article
    4. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein E330034G19Rik
    Names
    zygote-specific proteasome assembly chaperone

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033214.2 → NP_001028386.1  Protein E330034G19Rik isoform 1

      See identical proteins and their annotated locations for NP_001028386.1

      Status: VALIDATED

      Source sequence(s)
      AK136036
      Consensus CDS
      CCDS49418.1
      UniProtKB/TrEMBL
      E9PWE7, Q3UWX6, Q8C2V6
      Related
      ENSMUST00000239244.2
      Conserved Domains (2) summary
      cd16269
      Location:289 → 300
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:250 → 313
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001346536.1 → NP_001333465.1  Protein E330034G19Rik isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161374, BG067232, CA555840
      Consensus CDS
      CCDS88596.1
      UniProtKB/TrEMBL
      Q8C2V6
      Related
      ENSMUST00000162224.8

    3. NM_001379547.1 → NP_001366476.1  Protein E330034G19Rik isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161374
      UniProtKB/TrEMBL
      Q8C2V6
      Conserved Domains (1) summary
      TIGR02168
      Location:15 → 278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      24343282..24360028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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