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    Nbeal1 neurobeachin like 1 [ Mus musculus (house mouse) ]

    Gene ID: 269198, updated on 8-May-2024

    Summary

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    Official Symbol
    Nbeal1provided by MGI
    Official Full Name
    neurobeachin like 1provided by MGI
    Primary source
    MGI:MGI:2444343
    See related
    Ensembl:ENSMUSG00000073664 AllianceGenome:MGI:2444343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALS2CR17; 2310076G13Rik; A530050O19Rik; A530083I02Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytosol and membrane. Orthologous to human NBEAL1 (neurobeachin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.9), CNS E18 (RPKM 1.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C2; 1 30.46 cM
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60217910..60377487)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60178740..60338328)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:60154934-60155145 Neighboring gene WD repeat domain 12 Neighboring gene predicted gene 15464 Neighboring gene calcium response factor Neighboring gene STARR-seq mESC enhancer starr_01061 Neighboring gene STARR-positive B cell enhancer mm9_chr1:60297214-60297515 Neighboring gene STARR-seq mESC enhancer starr_01062 Neighboring gene STARR-seq mESC enhancer starr_01063 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_01064 Neighboring gene STARR-seq mESC enhancer starr_01065 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_01070 Neighboring gene abl interactor 2 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurobeachin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173444.2 → NP_775620.2  neurobeachin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AC158139, AK040951, AK143706, BC060141, BQ550685
      Consensus CDS
      CCDS48274.1
      UniProtKB/TrEMBL
      E9PYP2
      Related
      ENSMUSP00000124056.2, ENSMUST00000160834.8
      Conserved Domains (6) summary
      cd01201
      Location:1881 → 1978
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2439 → 2484
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1999 → 2278
      Beach; Beige/BEACH domain
      pfam15787
      Location:859 → 1129
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1575 → 1828
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2403 → 2676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60217910..60377487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496030.5 → XP_006496093.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496093.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006496033.5 → XP_006496096.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496096.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006496032.5 → XP_006496095.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496095.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_006496035.4 → XP_006496098.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496098.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_030254693.1 → XP_030110553.1  neurobeachin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PYP2
      Conserved Domains (6) summary
      cd01201
      Location:1881 → 1978
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2439 → 2484
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1999 → 2278
      Beach; Beige/BEACH domain
      pfam15787
      Location:859 → 1129
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1575 → 1828
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2403 → 2676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006496038.5 → XP_006496101.1  neurobeachin-like protein 1 isoform X5

      Conserved Domains (3) summary
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      pfam15787
      Location:888 → 1158
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)

    7. XM_030254697.2 → XP_030110557.1  neurobeachin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd01201
      Location:1731 → 1828
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2289 → 2334
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1849 → 2128
      Beach; Beige/BEACH domain
      pfam15787
      Location:709 → 979
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1425 → 1678
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2253 → 2526
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_011238527.4 → XP_011236829.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011236829.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_006496037.5 → XP_006496100.1  neurobeachin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd01201
      Location:1731 → 1828
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2289 → 2334
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1849 → 2128
      Beach; Beige/BEACH domain
      pfam15787
      Location:709 → 979
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1425 → 1678
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2253 → 2526
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_030254700.2 → XP_030110560.1  neurobeachin-like protein 1 isoform X4

      Conserved Domains (6) summary
      cd01201
      Location:1702 → 1799
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2260 → 2305
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1820 → 2099
      Beach; Beige/BEACH domain
      pfam15787
      Location:680 → 950
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1396 → 1649
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2224 → 2497
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_006496029.4 → XP_006496092.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496092.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_006496034.4 → XP_006496097.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496097.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_030254692.2 → XP_030110552.1  neurobeachin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PYP2
      Conserved Domains (6) summary
      cd01201
      Location:1881 → 1978
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2439 → 2484
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1999 → 2278
      Beach; Beige/BEACH domain
      pfam15787
      Location:859 → 1129
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1575 → 1828
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2403 → 2676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_030254694.2 → XP_030110554.1  neurobeachin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd01201
      Location:1731 → 1828
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2289 → 2334
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1849 → 2128
      Beach; Beige/BEACH domain
      pfam15787
      Location:709 → 979
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1425 → 1678
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2253 → 2526
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    15. XM_030254696.2 → XP_030110556.1  neurobeachin-like protein 1 isoform X3

      Conserved Domains (6) summary
      cd01201
      Location:1731 → 1828
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2289 → 2334
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1849 → 2128
      Beach; Beige/BEACH domain
      pfam15787
      Location:709 → 979
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1425 → 1678
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2253 → 2526
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    16. XM_006496028.5 → XP_006496091.1  neurobeachin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006496091.1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    17. XM_030254689.2 → XP_030110549.1  neurobeachin-like protein 1 isoform X2

      UniProtKB/TrEMBL
      E9PYP2
      Conserved Domains (6) summary
      cd01201
      Location:1881 → 1978
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2439 → 2484
      7WD40; WD40 repeat [structural motif]
      pfam02138
      Location:1999 → 2278
      Beach; Beige/BEACH domain
      pfam15787
      Location:859 → 1129
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1575 → 1828
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2403 → 2676
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    18. XM_036165459.1 → XP_036021352.1  neurobeachin-like protein 1 isoform X1

      Conserved Domains (6) summary
      smart01026
      Location:2027 → 2307
      Beach; Beige/BEACH domain
      cd01201
      Location:1910 → 2007
      PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
      sd00039
      Location:2468 → 2513
      7WD40; WD40 repeat [structural motif]
      pfam15787
      Location:888 → 1152
      DUF4704; Domain of unknown function (DUF4704)
      pfam16057
      Location:1604 → 1857
      DUF4800; Domain of unknown function (DUF4800)
      cl29593
      Location:2432 → 2705
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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