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Kalrn kalirin, RhoGEF kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 84009, updated on 25-Apr-2024

Summary

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Official Symbol: Kalrnprovided by RGD
Official Full Name: kalirin, RhoGEF kinaseprovided by RGD
Primary source: RGD:621865
See related: Ensembl:ENSRNOG00000001706 AllianceGenome:RGD:621865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Duo; Hapip; Kalirin
Summary: Enables enzyme binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; modification of postsynaptic actin cytoskeleton; and neurotransmitter receptor localization to postsynaptic specialization membrane. Located in neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density; and presynapse. Orthologous to human KALRN (kalirin RhoGEF kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 203.9), Heart (RPKM 67.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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Location:: 11q22

Exon count:: 67

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (79703345..80309210)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (66198155..66803166)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (69484293..70025682)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin.
Title: Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin.
Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
Title: Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling.
our results suggest that kalirin-7 may play a role in the early events leading to synapse degeneration
Title: Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.
that Cdk5 affects the function of Kal-7 on spine morphology and function via GluN2B and GluA1 receptors during dendritic spine formation
Title: Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines.
Mass spectrometry was used to quantify phosphorylation at 26 sites in Kal7 from individual adult rat nucleus accumbens and prefrontal cortex before and after exposure to acute or chronic cocaine. Region- and isoform-specific phosphorylation was observed along with region-specific effects of cocaine on Kal7 phosphorylation. Calpain cleaved Kal7 at 2 sites, separating N-terminal domain and PDZ binding motif from GEF domain.
Title: Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.
These results suggest that kalirin and Rac1 guanine nucleotide exchange factor play important roles in FSTL-1-mediated glucose regulation in skeletal muscle cells.
Title: Kalirin, a GEF for Rac1, plays an important role in FSTL-1-mediated glucose uptake in skeletal muscle cells.
Chronic unpredictable mild stress alters structural plasticity in the orbitofrontal cortex and is associated with decreased expression of kalirin.
Title: Orbitofrontal cortex 5-HT2A receptor mediates chronic stress-induced depressive-like behaviors and alterations of spine density and Kalirin7.
Results demonstrate that both endogenous kalirin-9 and endogenous kalirin-12 contribute to dendritic maturation in early development.
Title: Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.
Data show that scaffold protein X11alpha modulates kalirin-7 localization in dendrites and recruits it to Golgi outposts.
Title: Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.
The effects of NRG1 and erbB4 on spines were mediated by the RacGEF kalirin
Title: Neuregulin1 signaling promotes dendritic spine growth through kalirin.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049016 (e-PCR)
- UniSTS:145464

RH137364 (e-PCR)
- UniSTS:219452

RH137626 (e-PCR)
- UniSTS:219713

BE102756 (e-PCR)
- UniSTS:244342

D11Mgh3 (e-PCR)
- UniSTS:119430

BF396995 (e-PCR)
- UniSTS:245902

d11arb4 (e-PCR)
- UniSTS:120744

AU046621 (e-PCR)
- UniSTS:111279

BE110052 (e-PCR)
- UniSTS:245170

D11Got53 (e-PCR)
- UniSTS:112063

RH138291 (e-PCR)
- UniSTS:220378

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NMDA selective glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in habituation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within habituation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in maternal behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maternal behavior	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in parturition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maternal process involved in parturition	ISO Inferred from Sequence Orthology more info
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	EXP Inferred from Experiment more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kalirin

Names: P-CIP10; PAM COOH-terminal interactor protein 10; cyclin B1; huntingtin-associated protein interacting protein (duo); huntingtin-associated protein-interacting protein; protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain

NP_114451.2

EC 2.7.11.1

XP_038944566.1

EC 2.7.11.1

XP_038944567.1

EC 2.7.11.1

XP_038944568.1

EC 2.7.11.1

XP_038944569.1

EC 2.7.11.1

XP_038944570.1

EC 2.7.11.1

XP_038944571.1

EC 2.7.11.1

XP_038944572.1

EC 2.7.11.1

XP_038944573.1

EC 2.7.11.1

XP_038944574.1

EC 2.7.11.1

XP_038944575.1

EC 2.7.11.1

XP_038944576.1

EC 2.7.11.1

XP_038944577.1

EC 2.7.11.1

XP_038944578.1

EC 2.7.11.1

XP_038944579.1

EC 2.7.11.1

XP_038944580.1

EC 2.7.11.1

XP_038944581.1

EC 2.7.11.1

XP_038944582.1

EC 2.7.11.1

XP_038944583.1

EC 2.7.11.1

XP_038944584.1

EC 2.7.11.1

XP_038944585.1

EC 2.7.11.1

XP_038944586.1

EC 2.7.11.1

XP_038944588.1

EC 2.7.11.1

XP_038944589.1

EC 2.7.11.1

XP_038944590.1

EC 2.7.11.1

XP_038944591.1

EC 2.7.11.1

XP_038944592.1

EC 2.7.11.1

XP_038944593.1

EC 2.7.11.1

XP_038944594.1

EC 2.7.11.1

XP_038944595.1

EC 2.7.11.1

XP_063126848.1

EC 2.7.11.1

XP_063126849.1

EC 2.7.11.1

XP_063126850.1

EC 2.7.11.1

XP_063126851.1

EC 2.7.11.1

XP_063126852.1

EC 2.7.11.1

XP_063126853.1

EC 2.7.11.1

XP_063126854.1

EC 2.7.11.1

XP_063126855.1

EC 2.7.11.1

XP_063126856.1

EC 2.7.11.1

XP_063126857.1

EC 2.7.11.1

XP_063126858.1

EC 2.7.11.1

XP_063126859.1

EC 2.7.11.1

XP_063126860.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032062.2 → NP_114451.2 kalirin

Status: VALIDATED

Source sequence(s)

AF230644, AF232669

UniProtKB/TrEMBL

A0A8I6GKY9

Related

ENSRNOP00000094025.1, ENSRNOT00000117056.1

Conserved Domains (16) summary

cd00096
Location:2479 → 2553

Ig; Immunoglobulin domain

smart00150
Location:1126 → 1226

SPEC; Spectrin repeats

cd11852
Location:1640 → 1699

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2315 → 2373

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00220
Location:2675 → 2929

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2560 → 2651

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam07679
Location:2462 → 2556

I-set; Immunoglobulin I-set domain

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2097 → 2231

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2681 → 2928

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00169
Location:1485 → 1570

PH; PH domain

pfam00621
Location:1923 → 2093

RhoGEF; RhoGEF domain

pfam16609
Location:1696 → 1880

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

79703345..80309210

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088642.2 → XP_038944570.1 kalirin isoform X5

UniProtKB/TrEMBL

A0A8I6ACF7

Related

ENSRNOP00000089775.1

Conserved Domains (14) summary

smart00150
Location:1137 → 1237

SPEC; Spectrin repeats

cd11852
Location:1651 → 1710

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2324 → 2382

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2569 → 2660

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2107 → 2241

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2690 → 2937

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1933 → 2102

RhoGEF; RhoGEF domain

pfam07679
Location:2471 → 2565

I-set; Immunoglobulin I-set domain

pfam16609
Location:1707 → 1890

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2463 → 2466

Ig; Ig strand A [structural motif]
XM_039088658.2 → XP_038944586.1 kalirin isoform X27

UniProtKB/TrEMBL

A6IRJ3

Conserved Domains (7) summary

smart00150
Location:1128 → 1228

SPEC; Spectrin repeats

cd11852
Location:1642 → 1701

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1277 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1122

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1454 → 1576

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

pfam16609
Location:1698 → 1879

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_039088661.2 → XP_038944589.1 kalirin isoform X29

UniProtKB/TrEMBL

A0A8L2Q7U3, A6IRJ4

Related

ENSRNOP00000016340.8

Conserved Domains (6) summary

smart00150
Location:1137 → 1237

SPEC; Spectrin repeats

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1286 → 1456

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1131

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1463 → 1585

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:747 → 993

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_039088664.2 → XP_038944592.1 kalirin isoform X32

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (5) summary

smart00150
Location:1128 → 1228

SPEC; Spectrin repeats

smart00516
Location:41 → 179

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1277 → 1447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:893 → 1122

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1454 → 1576

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_039088640.2 → XP_038944568.1 kalirin isoform X3

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2326 → 2384

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2571 → 2662

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2108 → 2242

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2692 → 2939

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1934 → 2103

RhoGEF; RhoGEF domain

pfam07679
Location:2473 → 2567

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1891

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2465 → 2468

Ig; Ig strand A [structural motif]
XM_039088645.2 → XP_038944573.1 kalirin isoform X8

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1125 → 1225

SPEC; Spectrin repeats

cd11852
Location:1639 → 1698

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2314 → 2372

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2559 → 2650

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1274 → 1444

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:540 → 756

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1451 → 1573

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2096 → 2230

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2680 → 2927

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1922 → 2091

RhoGEF; RhoGEF domain

pfam07679
Location:2461 → 2555

I-set; Immunoglobulin I-set domain

pfam16609
Location:1695 → 1879

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2453 → 2456

Ig; Ig strand A [structural motif]
XM_039088647.2 → XP_038944575.1 kalirin isoform X10

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1116 → 1216

SPEC; Spectrin repeats

cd11852
Location:1630 → 1689

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2305 → 2363

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2550 → 2641

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1265 → 1435

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:881 → 1110

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1442 → 1564

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2087 → 2221

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2671 → 2918

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1913 → 2082

RhoGEF; RhoGEF domain

pfam07679
Location:2452 → 2546

I-set; Immunoglobulin I-set domain

pfam16609
Location:1686 → 1870

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2444 → 2447

Ig; Ig strand A [structural motif]
XM_039088638.2 → XP_038944566.1 kalirin isoform X1

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2572 → 2663

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2693 → 2940

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam07679
Location:2474 → 2568

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2466 → 2469

Ig; Ig strand A [structural motif]
XM_039088646.2 → XP_038944574.1 kalirin isoform X9

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2552 → 2643

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2673 → 2920

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam07679
Location:2454 → 2548

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2446 → 2449

Ig; Ig strand A [structural motif]
XM_039088639.2 → XP_038944567.1 kalirin isoform X2

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2326 → 2384

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2571 → 2662

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2692 → 2939

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam07679
Location:2473 → 2567

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2465 → 2468

Ig; Ig strand A [structural motif]
XM_039088650.2 → XP_038944578.1 kalirin isoform X14

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2295 → 2353

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2540 → 2631

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2077 → 2211

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2661 → 2908

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1903 → 2072

RhoGEF; RhoGEF domain

pfam07679
Location:2442 → 2536

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1847

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2434 → 2437

Ig; Ig strand A [structural motif]
XM_039088644.2 → XP_038944572.1 kalirin isoform X7

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1129 → 1229

SPEC; Spectrin repeats

cd11852
Location:1643 → 1702

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2318 → 2376

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2563 → 2654

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1278 → 1448

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1123

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1455 → 1577

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2100 → 2234

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2684 → 2931

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1926 → 2095

RhoGEF; RhoGEF domain

pfam07679
Location:2465 → 2559

I-set; Immunoglobulin I-set domain

pfam16609
Location:1699 → 1883

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2457 → 2460

Ig; Ig strand A [structural motif]
XM_039088641.2 → XP_038944569.1 kalirin isoform X4

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

cd11852
Location:1649 → 1708

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2324 → 2382

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2569 → 2660

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2106 → 2240

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2690 → 2937

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1932 → 2101

RhoGEF; RhoGEF domain

pfam07679
Location:2471 → 2565

I-set; Immunoglobulin I-set domain

pfam16609
Location:1705 → 1889

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2463 → 2466

Ig; Ig strand A [structural motif]
XM_039088643.2 → XP_038944571.1 kalirin isoform X6

UniProtKB/TrEMBL

A0A8I6GKY9

Related

ENSRNOP00000084297.1

Conserved Domains (14) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

cd11852
Location:1649 → 1708

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2323 → 2381

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2568 → 2659

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2106 → 2240

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2689 → 2936

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1932 → 2101

RhoGEF; RhoGEF domain

pfam07679
Location:2470 → 2564

I-set; Immunoglobulin I-set domain

pfam16609
Location:1705 → 1889

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2462 → 2465

Ig; Ig strand A [structural motif]
XM_039088649.2 → XP_038944577.1 kalirin isoform X12

UniProtKB/TrEMBL

A0A8I6GKY9

Conserved Domains (14) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2296 → 2354

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2541 → 2632

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2078 → 2212

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2662 → 2909

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1904 → 2073

RhoGEF; RhoGEF domain

pfam07679
Location:2443 → 2537

I-set; Immunoglobulin I-set domain

pfam16609
Location:1708 → 1848

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2435 → 2438

Ig; Ig strand A [structural motif]
XM_063270778.1 → XP_063126848.1 kalirin isoform X13

UniProtKB/TrEMBL

A0A8I6A0Z4
XM_039088666.2 → XP_038944594.1 kalirin isoform X34

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (6) summary

smart00150
Location:1125 → 1225

SPEC; Spectrin repeats

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1274 → 1444

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:540 → 756

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1451 → 1573

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:735 → 981

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_039088667.2 → XP_038944595.1 kalirin isoform X35

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (5) summary

smart00150
Location:1116 → 1216

SPEC; Spectrin repeats

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1265 → 1435

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:881 → 1110

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1442 → 1564

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_039088660.2 → XP_038944588.1 kalirin isoform X28

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (6) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:748 → 994

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_039088663.2 → XP_038944591.1 kalirin isoform X31

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (5) summary

smart00150
Location:1129 → 1229

SPEC; Spectrin repeats

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1278 → 1448

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1123

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1455 → 1577

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_039088662.2 → XP_038944590.1 kalirin isoform X30

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (6) summary

smart00150
Location:1135 → 1235

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1284 → 1454

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1129

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1461 → 1583

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

TIGR02168
Location:745 → 991

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_039088665.2 → XP_038944593.1 kalirin isoform X33

UniProtKB/TrEMBL

A6IRJ4

Conserved Domains (5) summary

smart00150
Location:1126 → 1226

SPEC; Spectrin repeats

smart00516
Location:39 → 177

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1275 → 1445

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:891 → 1120

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1452 → 1574

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
XM_039088651.2 → XP_038944579.1 kalirin isoform X15

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (11) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:748 → 994

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_039088654.2 → XP_038944582.1 kalirin isoform X21

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (11) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2325 → 2383

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2108 → 2242

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:748 → 994

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1934 → 2103

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1891

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_039088653.2 → XP_038944581.1 kalirin isoform X17

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (11) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:748 → 994

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_039088652.2 → XP_038944580.1 kalirin isoform X16

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (11) summary

smart00150
Location:1138 → 1238

SPEC; Spectrin repeats

cd11852
Location:1652 → 1711

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2327 → 2385

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1287 → 1457

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1132

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1464 → 1586

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2109 → 2243

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

TIGR02168
Location:748 → 994

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00621
Location:1935 → 2104

RhoGEF; RhoGEF domain

pfam16609
Location:1708 → 1892

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_063270779.1 → XP_063126849.1 kalirin isoform X18
XM_039088655.2 → XP_038944583.1 kalirin isoform X22

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (10) summary

smart00150
Location:1129 → 1229

SPEC; Spectrin repeats

cd11852
Location:1643 → 1702

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2318 → 2376

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:42 → 180

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1278 → 1448

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:894 → 1123

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1455 → 1577

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2100 → 2234

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1926 → 2095

RhoGEF; RhoGEF domain

pfam16609
Location:1699 → 1883

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_063270781.1 → XP_063126851.1 kalirin isoform X20
XM_063270780.1 → XP_063126850.1 kalirin isoform X19
XM_063270782.1 → XP_063126852.1 kalirin isoform X24
XM_063270783.1 → XP_063126853.1 kalirin isoform X25
XM_039088648.2 → XP_038944576.1 kalirin isoform X11

UniProtKB/Swiss-Prot

O70135, P97924, Q6IV51, Q9JIF1, Q9JIF2, Q9JIG0, Q9JIH3

UniProtKB/TrEMBL

A0A2X0SFF1

Conserved Domains (14) summary

smart00150
Location:1108 → 1208

SPEC; Spectrin repeats

cd11852
Location:1622 → 1681

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2297 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:21 → 159

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00063
Location:2542 → 2633

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:1257 → 1427

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:873 → 1102

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1434 → 1556

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2079 → 2213

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2663 → 2910

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1905 → 2074

RhoGEF; RhoGEF domain

pfam07679
Location:2444 → 2538

I-set; Immunoglobulin I-set domain

pfam16609
Location:1678 → 1862

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:2436 → 2439

Ig; Ig strand A [structural motif]
XM_039088656.2 → XP_038944584.1 kalirin isoform X23

UniProtKB/TrEMBL

A6IRJ0

Conserved Domains (10) summary

smart00150
Location:1108 → 1208

SPEC; Spectrin repeats

cd11852
Location:1622 → 1681

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:2297 → 2355

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

smart00516
Location:21 → 159

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:1257 → 1427

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:873 → 1102

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:1434 → 1556

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:2079 → 2213

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

pfam00621
Location:1905 → 2074

RhoGEF; RhoGEF domain

pfam16609
Location:1678 → 1862

SH3-RhoG_link; SH3-RhoGEF linking unstructured region
XM_039088657.2 → XP_038944585.1 kalirin isoform X26

UniProtKB/TrEMBL

A6IRI9

Conserved Domains (14) summary

smart00150
Location:494 → 594

SPEC; Spectrin repeats

cd11852
Location:1008 → 1067

SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin

cd11853
Location:1683 → 1741

SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin

cd00063
Location:1928 → 2019

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:643 → 813

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:250 → 488

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd13240
Location:820 → 942

PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1

cd13241
Location:1465 → 1599

PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2

cd14115
Location:2049 → 2296

STKc_Kalirin_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin

pfam00621
Location:1291 → 1460

RhoGEF; RhoGEF domain

pfam07679
Location:1830 → 1924

I-set; Immunoglobulin I-set domain

pfam16609
Location:1064 → 1248

SH3-RhoG_link; SH3-RhoGEF linking unstructured region

cd00096
Location:1822 → 1825

Ig; Ig strand A [structural motif]

cl02488
Location:5 → 249

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063270784.1 → XP_063126854.1 kalirin isoform X36
XM_063270785.1 → XP_063126855.1 kalirin isoform X37
XM_063270786.1 → XP_063126856.1 kalirin isoform X38
XM_063270789.1 → XP_063126859.1 kalirin isoform X41
XM_063270790.1 → XP_063126860.1 kalirin isoform X42
XM_063270787.1 → XP_063126857.1 kalirin isoform X39
XM_063270788.1 → XP_063126858.1 kalirin isoform X40