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    TNK2 tyrosine kinase non receptor 2 [ Homo sapiens (human) ]

    Gene ID: 10188, updated on 13-May-2024

    Summary

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    Official Symbol
    TNK2provided by HGNC
    Official Full Name
    tyrosine kinase non receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:19297
    See related
    Ensembl:ENSG00000061938 MIM:606994; AllianceGenome:HGNC:19297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACK; ACK1; ACK-1; p21cdc42Hs
    Summary
    This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q29
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (195863364..195908551, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (198449491..198494501)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195590235..195635422, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195543301-195544106 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:195547535-195548734 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr3:195550530-195551217 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67540 and experimental_67545 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_67549, experimental_67550 and experimental_67551 Neighboring gene MPRA-validated peak4987 silencer Neighboring gene uncharacterized LOC107984010 Neighboring gene long intergenic non-protein coding RNA 1983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195577694-195578194 Neighboring gene kinesin family member 3A pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195586662-195587186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195587187-195587709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195604399-195604953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195610157-195610657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195613501-195614264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195615031-195615794 Neighboring gene microRNA 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195623973-195624772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:195625602-195626282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21063 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195641665-195642277 Neighboring gene TNK2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195652784-195653752 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195653753-195654721 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:195654722-195655690 Neighboring gene RNA, U2 small nuclear 11, pseudogene Neighboring gene mucin-5AC-like Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer. Hodder S, et al. Small GTPases, 2023 Dec. PMID 37194323, Free PMC Article
    2. Host factor TNK2 is required for influenza virus infection. Zhou A, et al. Genes Genomics, 2023 Jun. PMID 37133719
    3. Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1. Kan Y, et al. Cells, 2023 Mar 15. PMID 36980241, Free PMC Article
    4. Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer. Zhu J, et al. Aging (Albany NY), 2021 Jan 20. PMID 33495411, Free PMC Article
    5. TNK2 promoted esophageal cancer progression via activating egfr-akt signaling. Zhang A, et al. J Clin Lab Anal, 2021 Mar. PMID 33484472, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
      Title: ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway.
    2. Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
      Title: Activation of E3 ubiquitin ligase WWP2 by non-receptor tyrosine kinase ACK1.
    3. Host factor TNK2 is required for influenza virus infection.
      Title: Host factor TNK2 is required for influenza virus infection.
    4. ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
      Title: ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
    5. Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
      Title: Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1.
    6. Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
      Title: Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
    7. Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
      Title: Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region.
    8. Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
      Title: Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.
    9. Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
      Title: Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition.
    10. TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
      Title: TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (72)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44758, FLJ45547

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables WW domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Grb2-EGFR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoophidium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activated CDC42 kinase 1
    Names
    activated Cdc42-associated kinase 1
    activated p21cdc42Hs kinase
    tyrosine kinase non-receptor protein 2
    NP_001010938.2
    NP_001294975.1
    NP_001369200.1
    NP_001369201.1
    NP_001369202.1
    NP_001369203.1
    NP_001369204.1
    NP_001373093.1
    NP_001374636.1
    NP_001374637.1
    NP_001374638.1
    NP_001374639.1
    NP_001374640.1
    NP_001374641.1
    NP_001374642.1
    NP_001374643.1
    NP_001374644.1
    NP_001374645.1
    NP_001374646.1
    NP_001374647.1
    NP_001374648.1
    NP_001374649.1
    NP_001374650.1
    NP_005772.3
    XP_011510619.2
    XP_011510620.2
    XP_011510623.1
    XP_016860998.1
    XP_024309059.2
    XP_024309060.1
    XP_024309061.1
    XP_024309063.1
    XP_047303097.1
    XP_047303098.1
    XP_047303099.1
    XP_047303100.1
    XP_047303101.1
    XP_047303102.1
    XP_047303103.1
    XP_047303104.1
    XP_047303105.1
    XP_047303106.1
    XP_047303107.1
    XP_047303108.1
    XP_047303109.1
    XP_047303110.1
    XP_047303111.1
    XP_047303112.1
    XP_047303113.1
    XP_047303114.1
    XP_047303115.1
    XP_047303116.1
    XP_047303117.1
    XP_047303118.1
    XP_047303119.1
    XP_047303120.1
    XP_047303121.1
    XP_047303122.1
    XP_054200826.1
    XP_054200827.1
    XP_054200828.1
    XP_054200829.1
    XP_054200830.1
    XP_054200831.1
    XP_054200832.1
    XP_054200833.1
    XP_054200834.1
    XP_054200835.1
    XP_054200836.1
    XP_054200837.1
    XP_054200838.1
    XP_054200839.1
    XP_054200840.1
    XP_054200841.1
    XP_054200842.1
    XP_054200843.1
    XP_054200844.1
    XP_054200845.1
    XP_054200846.1
    XP_054200847.1
    XP_054200848.1
    XP_054200849.1
    XP_054200850.1
    XP_054200851.1
    XP_054200852.1
    XP_054200853.1
    XP_054200854.1
    XP_054200855.1
    XP_054200856.1
    XP_054200857.1
    XP_054200858.1
    XP_054200859.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029779.1 RefSeqGene

      Range
      5459..50646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001010938.2 → NP_001010938.2  activated CDC42 kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 5' UTR and 5' coding region, lacks one alternate 3' coding exon, and contains a different alternate 3' coding exon, as compared to variant 1. The translation remains in-frame, and results in a longer isoform (2) that has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK127455, AK131539, BC020395, L13738
      Consensus CDS
      CCDS33927.2
      UniProtKB/TrEMBL
      A0A499FJ16
      Related
      ENSP00000499858.1, ENST00000671753.1
      Conserved Domains (7) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582 → 888
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:998 → 1037
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813 → 879
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    2. NM_001308046.2 → NP_001294975.1  activated CDC42 kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' exon, contains an alternate 5' terminal exon, lacks one alternate 3' coding exon, and initiates translation at an alternate start codon, compared to variant 1. It encodes a shorter isoform (3) that has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS77875.1
      UniProtKB/TrEMBL
      A0A499FJ16, C9J1X3
      Related
      ENSP00000392546.1, ENST00000428187.7
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:158 → 417
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:479 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    3. NM_001382271.1 → NP_001369200.1  activated CDC42 kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93443.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHJ2
      Related
      ENSP00000503221.1, ENST00000678220.1
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:575 → 881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:993 → 1036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1023 → 1062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:806 → 870
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    4. NM_001382272.1 → NP_001369201.1  activated CDC42 kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:582 → 888
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1000 → 1043
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1030 → 1069
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:813 → 877
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    5. NM_001382273.1 → NP_001369202.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93442.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Related
      ENSP00000499899.1, ENST00000672887.2
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:976 → 1019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    6. NM_001382274.1 → NP_001369203.1  activated CDC42 kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93442.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:976 → 1019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    7. NM_001382275.1 → NP_001369204.1  activated CDC42 kinase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590 → 896
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    8. NM_001386164.1 → NP_001373093.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Related
      ENSP00000500887.1, ENST00000673420.1
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    9. NM_001387707.1 → NP_001374636.1  activated CDC42 kinase 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:38 → 99
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:590 → 896
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:1008 → 1051
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1038 → 1077
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:162 → 419
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:481 → 546
      GTPase_binding; GTPase binding
      pfam11555
      Location:821 → 885
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:427 → 476
      SH3_9; Variant SH3 domain

    10. NM_001387708.1 → NP_001374637.1  activated CDC42 kinase 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567 → 873
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:985 → 1028
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1015 → 1054
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798 → 862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    11. NM_001387709.1 → NP_001374638.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    12. NM_001387710.1 → NP_001374639.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    13. NM_001387711.1 → NP_001374640.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    14. NM_001387712.1 → NP_001374641.1  activated CDC42 kinase 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93441.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZI29
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:961 → 1004
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:991 → 1030
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    15. NM_001387713.1 → NP_001374642.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:958 → 1002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:989 → 1028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    16. NM_001387714.1 → NP_001374643.1  activated CDC42 kinase 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:958 → 1002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:989 → 1028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    17. NM_001387715.1 → NP_001374644.1  activated CDC42 kinase 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:30 → 91
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:567 → 873
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:983 → 1022
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:154 → 411
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:473 → 538
      GTPase_binding; GTPase binding
      pfam11555
      Location:798 → 862
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:419 → 468
      SH3_9; Variant SH3 domain

    18. NM_001387716.1 → NP_001374645.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:974 → 1013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    19. NM_001387717.1 → NP_001374646.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:974 → 1013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    20. NM_001387718.1 → NP_001374647.1  activated CDC42 kinase 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC124944
      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:974 → 1013
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    21. NM_001387719.1 → NP_001374648.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959 → 998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    22. NM_001387720.1 → NP_001374649.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Related
      ENSP00000500486.1, ENST00000672024.1
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959 → 998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    23. NM_001387721.1 → NP_001374650.1  activated CDC42 kinase 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC124944
      Consensus CDS
      CCDS93440.1
      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZHP4
      Conserved Domains (7) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14328
      Location:959 → 998
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    24. NM_005781.5 → NP_005772.3  activated CDC42 kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_005772.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the more frequently occurring transcript and it encodes isoform 1.
      Source sequence(s)
      AC124944, AK127455, AK131539, BG742978, CN411136, L13738
      Consensus CDS
      CCDS33928.1
      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59
      UniProtKB/TrEMBL
      A0A499FJ16
      Related
      ENSP00000329425.6, ENST00000333602.14
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:543 → 849
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:958 → 1002
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:989 → 1028
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:774 → 838
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    RNA

    1. NR_170678.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    2. NR_170679.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    3. NR_170680.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    4. NR_170681.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    5. NR_170682.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    6. NR_170683.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    7. NR_170684.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    8. NR_170685.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    9. NR_170686.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    10. NR_170687.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    11. NR_170688.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    12. NR_170689.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    13. NR_170690.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    14. NR_170691.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    15. NR_170692.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC124944

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      195863364..195908551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447154.1 → XP_047303110.1  activated CDC42 kinase 1 isoform X15

    2. XM_047447157.1 → XP_047303113.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    3. XM_047447153.1 → XP_047303109.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    4. XM_047447161.1 → XP_047303117.1  activated CDC42 kinase 1 isoform X19

    5. XM_047447143.1 → XP_047303099.1  activated CDC42 kinase 1 isoform X1

    6. XM_047447142.1 → XP_047303098.1  activated CDC42 kinase 1 isoform X1

    7. XM_047447162.1 → XP_047303118.1  activated CDC42 kinase 1 isoform X20

    8. XM_047447156.1 → XP_047303112.1  activated CDC42 kinase 1 isoform X17

    9. XM_024453292.2 → XP_024309060.1  activated CDC42 kinase 1 isoform X14

      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (6) summary
      cd09539
      Location:23 → 84
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00326
      Location:410 → 461
      SH3; Src homology 3 domains
      PHA03247
      Location:575 → 881
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:993 → 1036
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1023 → 1062
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:147 → 404
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    10. XM_047447150.1 → XP_047303106.1  activated CDC42 kinase 1 isoform X11

    11. XM_047447160.1 → XP_047303116.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59

    12. XM_047447159.1 → XP_047303115.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A5F9ZI29

    13. XM_047447158.1 → XP_047303114.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    14. XM_024453295.2 → XP_024309063.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:976 → 1019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    15. XM_047447141.1 → XP_047303097.1  activated CDC42 kinase 1 isoform X1

    16. XM_047447151.1 → XP_047303107.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59

    17. XM_024453291.2 → XP_024309059.2  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    18. XM_047447148.1 → XP_047303104.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      C9J1X3

    19. XM_047447146.1 → XP_047303102.1  activated CDC42 kinase 1 isoform X6

    20. XM_047447145.1 → XP_047303101.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    21. XM_047447147.1 → XP_047303103.1  activated CDC42 kinase 1 isoform X8

    22. XM_011512318.3 → XP_011510620.2  activated CDC42 kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJ16

    23. XM_011512317.4 → XP_011510619.2  activated CDC42 kinase 1 isoform X2

    24. XM_047447152.1 → XP_047303108.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    25. XM_024453293.2 → XP_024309061.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A499FJ16, A0A5F9ZGX5
      Conserved Domains (8) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      PHA03247
      Location:558 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd14274
      Location:976 → 1019
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:1006 → 1045
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:130 → 387
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:449 → 514
      GTPase_binding; GTPase binding
      pfam11555
      Location:789 → 853
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:395 → 444
      SH3_9; Variant SH3 domain

    26. XM_047447155.1 → XP_047303111.1  activated CDC42 kinase 1 isoform X16

    27. XM_047447163.1 → XP_047303119.1  activated CDC42 kinase 1 isoform X22

    28. XM_011512321.2 → XP_011510623.1  activated CDC42 kinase 1 isoform X21

      UniProtKB/TrEMBL
      A0A499FJ16
      Conserved Domains (7) summary
      smart00221
      Location:50 → 309
      STYKc; Protein kinase; unclassified specificity
      cd14274
      Location:900 → 943
      UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
      cd14328
      Location:930 → 969
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cd05040
      Location:54 → 311
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
      pfam09027
      Location:371 → 438
      GTPase_binding; GTPase binding
      pfam11555
      Location:713 → 777
      Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
      pfam14604
      Location:319 → 368
      SH3_9; Variant SH3 domain

    29. XM_047447164.1 → XP_047303120.1  activated CDC42 kinase 1 isoform X23

    30. XM_047447165.1 → XP_047303121.1  activated CDC42 kinase 1 isoform X23

    31. XM_047447166.1 → XP_047303122.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4
      Related
      ENSP00000500238.1, ENST00000672548.1

    32. XM_047447149.1 → XP_047303105.1  activated CDC42 kinase 1 isoform X10

    33. XM_017005509.2 → XP_016860998.1  activated CDC42 kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A499FJ16

    34. XM_047447144.1 → XP_047303100.1  activated CDC42 kinase 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      198449491..198494501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344851.1 → XP_054200826.1  activated CDC42 kinase 1 isoform X1

    2. XM_054344852.1 → XP_054200827.1  activated CDC42 kinase 1 isoform X1

    3. XM_054344877.1 → XP_054200852.1  activated CDC42 kinase 1 isoform X19

    4. XM_054344867.1 → XP_054200842.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    5. XM_054344872.1 → XP_054200847.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    6. XM_054344862.1 → XP_054200837.1  activated CDC42 kinase 1 isoform X11

    7. XM_054344865.1 → XP_054200840.1  activated CDC42 kinase 1 isoform X14

    8. XM_054344869.1 → XP_054200844.1  activated CDC42 kinase 1 isoform X17

    9. XM_054344878.1 → XP_054200853.1  activated CDC42 kinase 1 isoform X20

    10. XM_054344875.1 → XP_054200850.1  activated CDC42 kinase 1 isoform X18

      UniProtKB/TrEMBL
      A0A5F9ZI29

    11. XM_054344876.1 → XP_054200851.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59

    12. XM_054344873.1 → XP_054200848.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    13. XM_054344874.1 → XP_054200849.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    14. XM_054344871.1 → XP_054200846.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    15. XM_054344855.1 → XP_054200830.1  activated CDC42 kinase 1 isoform X4

    16. XM_054344859.1 → XP_054200834.1  activated CDC42 kinase 1 isoform X8

    17. XM_054344856.1 → XP_054200831.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    18. XM_054344857.1 → XP_054200832.1  activated CDC42 kinase 1 isoform X6

    19. XM_054344860.1 → XP_054200835.1  activated CDC42 kinase 1 isoform X9

      UniProtKB/TrEMBL
      C9J1X3

    20. XM_054344863.1 → XP_054200838.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    21. XM_054344864.1 → XP_054200839.1  activated CDC42 kinase 1 isoform X13

      UniProtKB/Swiss-Prot
      Q07912, Q6ZMQ0, Q8N6U7, Q96H59

    22. XM_054344854.1 → XP_054200829.1  activated CDC42 kinase 1 isoform X3

    23. XM_054344858.1 → XP_054200833.1  activated CDC42 kinase 1 isoform X7

    24. XM_054344861.1 → XP_054200836.1  activated CDC42 kinase 1 isoform X10

    25. XM_054344866.1 → XP_054200841.1  activated CDC42 kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A5F9ZHJ2

    26. XM_054344853.1 → XP_054200828.1  activated CDC42 kinase 1 isoform X2

    27. XM_054344870.1 → XP_054200845.1  activated CDC42 kinase 1 isoform X12

      UniProtKB/TrEMBL
      A0A5F9ZGX5

    28. XM_054344868.1 → XP_054200843.1  activated CDC42 kinase 1 isoform X16

    29. XM_054344879.1 → XP_054200854.1  activated CDC42 kinase 1 isoform X21

    30. XM_054344880.1 → XP_054200855.1  activated CDC42 kinase 1 isoform X22

    31. XM_054344881.1 → XP_054200856.1  activated CDC42 kinase 1 isoform X23

    32. XM_054344882.1 → XP_054200857.1  activated CDC42 kinase 1 isoform X23

    33. XM_054344883.1 → XP_054200858.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4

    34. XM_054344884.1 → XP_054200859.1  activated CDC42 kinase 1 isoform X24

      UniProtKB/TrEMBL
      B3KXJ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07912.3 GenPept UniProtKB/Swiss-Prot:Q07912

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