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    Naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit [ Mus musculus (house mouse) ]

    Gene ID: 231713, updated on 12-May-2024

    Summary

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    Official Symbol
    Naa25provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 25, NatB auxiliary subunitprovided by MGI
    Primary source
    MGI:MGI:2442563
    See related
    Ensembl:ENSMUSG00000042719 AllianceGenome:MGI:2442563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdm20; A630046C11; 4833422K13Rik; C330023M02Rik
    Summary
    Predicted to contribute to peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; hair; heart; spinal cord; and stomach. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.4), whole brain E14.5 (RPKM 8.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 61.79 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121535977..121580612)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121397914..121442549)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene predicted gene, 24671 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene predicted gene, 42020 Neighboring gene STARR-seq mESC enhancer starr_14257 Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene transmembrane protein 116 Neighboring gene mitogen-activated protein kinase 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-terminal acetylation modulates Bax targeting to mitochondria. Alves S, et al. Int J Biochem Cell Biol, 2018 Feb. PMID 29233735
    2. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Ohyama K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22101279
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 25, NatB auxiliary subunit
    Names
    N-terminal acetyltransferase B complex subunit MDM20
    N-terminal acetyltransferase B complex subunit NAA25
    mitochondrial distribution and morphology protein 20
    natB complex subunit MDM20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172722.4 → NP_766310.2  N-alpha-acetyltransferase 25, NatB auxiliary subunit

      See identical proteins and their annotated locations for NP_766310.2

      Status: VALIDATED

      Source sequence(s)
      AC129215, AK049325, AK051815, AK076483, BX521975, CF742186
      Consensus CDS
      CCDS19633.1
      UniProtKB/Swiss-Prot
      A1A4B7, Q3KQI7, Q3TJC6, Q7TMM2, Q8BWZ3
      UniProtKB/TrEMBL
      B2RQV1
      Related
      ENSMUSP00000038977.9, ENSMUST00000042163.15
      Conserved Domains (2) summary
      sd00006
      Location:47 → 73
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:263 → 655
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121535977..121580612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248198.3 → XP_011246500.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

      Conserved Domains (3) summary
      TIGR02917
      Location:2 → 185
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:19 → 45
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:236 → 630
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

    RNA

    1. XR_001784683.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWZ3.1 GenPept UniProtKB/Swiss-Prot:Q8BWZ3

    Gene LinkOut

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