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    GPR176 G protein-coupled receptor 176 [ Homo sapiens (human) ]

    Gene ID: 11245, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR176provided by HGNC
    Official Full Name
    G protein-coupled receptor 176provided by HGNC
    Primary source
    HGNC:HGNC:32370
    See related
    Ensembl:ENSG00000166073 MIM:612183; AllianceGenome:HGNC:32370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB-954
    Summary
    Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
    Expression
    Broad expression in brain (RPKM 2.2), testis (RPKM 1.7) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q14-q15.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (39799008..39920266, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (37604203..37725586, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40091209..40212467, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370785 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:39958804-39959320 Neighboring gene Sharpr-MPRA regulatory region 4200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6312 Neighboring gene uncharacterized LOC105370941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9217 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176182-40176852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40176853-40177522 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40177802-40178334 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:40179399-40179929 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40178335-40178866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40186807-40187332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40200676-40201176 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40209802-40209908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40211506-40212311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6314 Neighboring gene GPR176 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9219 Neighboring gene small nucleolar RNA U13 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells. Zhang Y, et al. Sci Rep, 2023 Jun 8. PMID 37291181, Free PMC Article
    2. cDNA cloning of a putative G protein-coupled receptor from brain. Hata S, et al. Biochim Biophys Acta, 1995 Mar 14. PMID 7893747
    3. G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]. Goto K, et al. Endocr J, 2017 Jun 29. PMID 28502923
    4. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. Tang J, et al. Adv Sci (Weinh), 2023 Apr. PMID 36905238, Free PMC Article
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
      Title: The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.
    2. High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
      Title: High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.
    3. GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
      Title: GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.
    4. Data suggest that Gpr176 is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior. [REVIEW]
      Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 176
    Names
    probable G-protein coupled receptor 176

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271854.2 → NP_001258783.1  G-protein coupled receptor 176 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC012377, AC023908
      Consensus CDS
      CCDS61589.1
      UniProtKB/Swiss-Prot
      Q14439
      Related
      ENSP00000299092.3, ENST00000299092.4
      Conserved Domains (1) summary
      pfam00001
      Location:78 → 318
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_001271855.2 → NP_001258784.1  G-protein coupled receptor 176 isoform 3

      See identical proteins and their annotated locations for NP_001258784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC023908
      Consensus CDS
      CCDS61588.1
      UniProtKB/Swiss-Prot
      Q14439
      Related
      ENSP00000439361.1, ENST00000543580.7
      Conserved Domains (1) summary
      pfam00001
      Location:13 → 274
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_007223.3 → NP_009154.1  G-protein coupled receptor 176 isoform 1

      See identical proteins and their annotated locations for NP_009154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC012377, AC023908
      Consensus CDS
      CCDS10051.1
      UniProtKB/Swiss-Prot
      B4DZ23, H9NIL9, J3KNC6, Q14439, Q6NXF6
      Related
      ENSP00000453076.1, ENST00000561100.2
      Conserved Domains (1) summary
      pfam00001
      Location:58 → 319
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      39799008..39920266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021878.3 → XP_016877367.1  G-protein coupled receptor 176 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:1 → 14
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 168
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_017021873.3 → XP_016877362.1  G-protein coupled receptor 176 isoform X1

      Conserved Domains (1) summary
      pfam00001
      Location:26 → 287
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_011521167.4 → XP_011519469.1  G-protein coupled receptor 176 isoform X1

      See identical proteins and their annotated locations for XP_011519469.1

      Conserved Domains (1) summary
      pfam00001
      Location:26 → 287
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    4. XM_017021874.3 → XP_016877363.1  G-protein coupled receptor 176 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:1 → 14
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 168
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_024449835.2 → XP_024305603.1  G-protein coupled receptor 176 isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:1 → 14
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1 → 168
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      37604203..37725586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377224.1 → XP_054233199.1  G-protein coupled receptor 176 isoform X2

    2. XM_054377221.1 → XP_054233196.1  G-protein coupled receptor 176 isoform X1

    3. XM_054377220.1 → XP_054233195.1  G-protein coupled receptor 176 isoform X1

    4. XM_054377222.1 → XP_054233197.1  G-protein coupled receptor 176 isoform X2

    5. XM_054377223.1 → XP_054233198.1  G-protein coupled receptor 176 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14439.1 GenPept UniProtKB/Swiss-Prot:Q14439

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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