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    dhcr7.L 7-dehydrocholesterol reductase L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 380248, updated on 11-Apr-2024

    Summary

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    Official Symbol
    dhcr7.L
    Official Full Name
    7-dehydrocholesterol reductase L homeolog
    Primary source
    Xenbase:XB-GENE-920377
    Locus tag
    XELAEV_18021759mg
    See related
    EnsemblRapid:ENSXLAG00005019715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    dhcr7; 7-Dhcr; Xdhcr7
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    Genomic context

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    Location:
    chromosome: 4L
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (3411501..3420570)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (3469064..3472065)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 5 L homeolog Neighboring gene neural EGFL like 1 L homeolog Neighboring gene U2 spliceosomal RNA Neighboring gene growth arrest specific 2 L homeolog Neighboring gene solute carrier family 17 member 6 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cholesterol homeostasis in development: the role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development. Tadjuidje E, et al. Dev Dyn, 2006 Aug. PMID 16752377
    2. Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase. Koide T, et al. Development, 2006 Jun. PMID 16687448
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system
      Title: Cholesterol homeostasis in development: the role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development.
    2. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos.
      Title: Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC64361

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 7-dehydrocholesterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    7-dehydrocholesterol reductase L homeolog
    NP_001080556.1
    XP_041445100.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087087.1 → NP_001080556.1  7-dehydrocholesterol reductase L homeolog

      See identical proteins and their annotated locations for NP_001080556.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054203
      UniProtKB/TrEMBL
      Q7SYZ9
      Related
      ENSXLAP00005057927.1, ENSXLAT00005059281.1
      Conserved Domains (1) summary
      cl21511
      Location:97 → 340
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      3411501..3420570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041589166.1 → XP_041445100.1  7-dehydrocholesterol reductase L homeolog isoform X1

      UniProtKB/TrEMBL
      A0A1L8GIE0, A0A974D276, Q1WAJ9
      Related
      ENSXLAP00005057913.1, ENSXLAT00005059267.1
      Conserved Domains (1) summary
      cl21511
      Location:97 → 473
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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