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    Fem1c fem 1 homolog c [ Mus musculus (house mouse) ]

    Gene ID: 240263, updated on 12-May-2024

    Summary

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    Official Symbol
    Fem1cprovided by MGI
    Official Full Name
    fem 1 homolog cprovided by MGI
    Primary source
    MGI:MGI:2444737
    See related
    Ensembl:ENSMUSG00000033319 AllianceGenome:MGI:2444737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610312A07Rik; 3632443A22Rik
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in several structures, including 1st branchial arch; central nervous system; limb; maxillary process; and sensory organ. Orthologous to human FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 52.8), placenta adult (RPKM 7.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 C; 18 24.62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46637673..46659038, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46504606..46525971, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4107 Neighboring gene STARR-seq mESC enhancer starr_44505 Neighboring gene predicted gene, 57821 Neighboring gene motile sperm domain containing 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:46685913-46686022 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene RAD51 homolog c pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice. Schlamp CL, et al. Mol Cell Biol, 2004 May. PMID 15082774, Free PMC Article
    2. The Fem1c genes: conserved members of the Fem1 gene family in vertebrates. Ventura-Holman T, et al. Gene, 2003 Sep 18. PMID 14527725
    3. Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Pelzel HR, et al. Invest Ophthalmol Vis Sci, 2012 Mar. PMID 22297488, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein fem-1 homolog C
    Names
    FEM1-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173423.4 → NP_775599.1  protein fem-1 homolog C

      Status: PROVISIONAL

      Source sequence(s)
      AC148017
      Consensus CDS
      CCDS29231.1
      UniProtKB/Swiss-Prot
      Q3UGV8, Q8C7S4, Q8CEF1
      UniProtKB/TrEMBL
      B2RRW5
      Related
      ENSMUSP00000038816.6, ENSMUST00000036226.6
      Conserved Domains (4) summary
      cd00204
      Location:73 → 202
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:87 → 178
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:482 → 548
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:118 → 146
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      46637673..46659038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CEF1.1 GenPept UniProtKB/Swiss-Prot:Q8CEF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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