Wdhd1 WD repeat and HMG-box DNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdhd1provided by MGI
Official Full Name: WD repeat and HMG-box DNA binding protein 1provided by MGI
Primary source: MGI:MGI:2443514
See related: Ensembl:ENSMUSG00000037572 AllianceGenome:MGI:2443514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AND-1; A630092E18; D630024B06Rik
Summary: Enables RNA binding activity; RNA polymerase binding activity; and chromatin binding activity. Acts upstream of or within RNA processing; pericentric heterochromatin organization; and regulation of chromosome organization. Located in chromosome, centromeric region. Is expressed in brain ventricular layer; inferior colliculus; submandibular gland primordium; and thymus primordium. Orthologous to human WDHD1 (WD repeat and HMG-box DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 17.1), liver E14.5 (RPKM 13.7) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (47478401..47514352, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (47240944..47276861, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Wdhd1 is essential for early mouse embryogenesis.
Title: Wdhd1 is essential for early mouse embryogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within RNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pericentric heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat and HMG-box DNA-binding protein 1

Names: acidic nucleoplasmic DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360532.1 → NP_001347461.1 WD repeat and HMG-box DNA-binding protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC156016, AK036390, AK052690, AK160777, BE980284, BQ748927, BY210513, CF163129

Consensus CDS

CCDS88642.1

UniProtKB/Swiss-Prot

P59328, Q6P408

UniProtKB/TrEMBL

A0A2K6EDP7

Related

ENSMUSP00000141182.3, ENSMUST00000187531.8

Conserved Domains (5) summary

smart00398
Location:1006 → 1063

HMG; high mobility group

COG5648
Location:949 → 1061

NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]

cd00200
Location:10 → 289

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:21 → 54

7WD40; WD40 repeat [structural motif]

pfam12341
Location:425 → 707

Mcl1_mid; Minichromosome loss protein, Mcl1, middle region
NM_172598.3 → NP_766186.2 WD repeat and HMG-box DNA-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_766186.2

Status: VALIDATED

Source sequence(s)

AC156016, BC063740

Consensus CDS

CCDS88641.1

UniProtKB/Swiss-Prot

P59328, Q6P408

UniProtKB/TrEMBL

A0A0R4J1F8

Related

ENSMUSP00000107422.2, ENSMUST00000111792.9

Conserved Domains (5) summary

smart00398
Location:969 → 1026

HMG; high mobility group

COG2319
Location:1 → 303

WD40; WD40 repeat [General function prediction only]

cd00200
Location:10 → 289

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12341
Location:388 → 670

Mcl1_mid; Minichromosome loss protein, Mcl1, middle region

sd00039
Location:21 → 54

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

47478401..47514352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245012.4 → XP_011243314.1 WD repeat and HMG-box DNA-binding protein 1 isoform X1

Related

ENSMUSP00000107420.2, ENSMUST00000111790.2

Conserved Domains (3) summary

cd00200
Location:10 → 289

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:21 → 54

7WD40; WD40 repeat [structural motif]

pfam12341
Location:424 → 589

Mcl1_mid; Minichromosome loss protein, Mcl1, middle region