U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ankib1 ankyrin repeat and IBR domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 70797, updated on 7-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ankib1provided by MGI
    Official Full Name
    ankyrin repeat and IBR domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918047
    See related
    Ensembl:ENSMUSG00000040351 AllianceGenome:MGI:1918047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1386; 2310061P20Rik; 4631416I11Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human ANKIB1 (ankyrin repeat and IBR domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 7.8), CNS E18 (RPKM 6.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5 A1; 5 2.26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (3739999..3853124, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (3689999..3803124, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12316 Neighboring gene GATA zinc finger domain containing 1 Neighboring gene predicted gene, 50624 Neighboring gene STARR-seq mESC enhancer starr_12317 Neighboring gene transmembrane BAX inhibitor motif containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E4742 Neighboring gene STARR-seq mESC enhancer starr_12318 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene mitochondrial transcription termination factor 1a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC90780

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ankyrin repeat and IBR domain-containing protein 1
    NP_001003909.2
    NP_001276456.1
    NP_001276457.1
    NP_001276458.1
    XP_017176586.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003909.4 → NP_001003909.2  ankyrin repeat and IBR domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001003909.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC022236
      Consensus CDS
      CCDS51408.1
      UniProtKB/Swiss-Prot
      Q6AXE1, Q6ZPS6
      UniProtKB/TrEMBL
      B2RX15
      Related
      ENSMUSP00000040946.7, ENSMUST00000043551.11
      Conserved Domains (5) summary
      cd00204
      Location:47 → 198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50 → 176
      Ank_2; Ankyrin repeats (3 copies)
      pfam13639
      Location:334 → 380
      zf-RING_2; Ring finger domain
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]

    2. NM_001289527.1 → NP_001276456.1  ankyrin repeat and IBR domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001276456.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC022236
      UniProtKB/TrEMBL
      B2RX15
      Conserved Domains (4) summary
      COG0666
      Location:28 → 199
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]
      cd16774
      Location:333 → 389
      RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain

    3. NM_001289528.1 → NP_001276457.1  ankyrin repeat and IBR domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region and uses an alternate in-frame splice site in the 3' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC022236, BC079620, BC145510, CN526058
      UniProtKB/Swiss-Prot
      Q6ZPS6
      Conserved Domains (2) summary
      pfam01485
      Location:129 → 202
      IBR; IBR domain, a half RING-finger domain
      pfam13639
      Location:60 → 106
      zf-RING_2; Ring finger domain

    4. NM_001289529.1 → NP_001276458.1  ankyrin repeat and IBR domain-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR and contains an alternate exon in the 5' region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK014523, BC079620, BC089031, CN526058
      UniProtKB/Swiss-Prot
      Q6ZPS6
      Conserved Domains (1) summary
      pfam01485
      Location:11 → 62
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      3739999..3853124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321097.1 → XP_017176586.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RX15
      Conserved Domains (4) summary
      COG0666
      Location:28 → 199
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]
      cd16774
      Location:333 → 389
      RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPS6.2 GenPept UniProtKB/Swiss-Prot:Q6ZPS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous