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    ZNF662 zinc finger protein 662 [ Homo sapiens (human) ]

    Gene ID: 389114, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF662provided by HGNC
    Official Full Name
    zinc finger protein 662provided by HGNC
    Primary source
    HGNC:HGNC:31930
    See related
    Ensembl:ENSG00000182983 AllianceGenome:HGNC:31930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in skin (RPKM 4.3), endometrium (RPKM 3.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    3p22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42906142..42919334)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42921723..42934975)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42947634..42960826)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:42916634-42916810 Neighboring gene Sharpr-MPRA regulatory region 13936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14252 Neighboring gene cytochrome P450 family 8 subfamily B member 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:42931092-42931592 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 22 Neighboring gene KRBOX1 antisense RNA 1 Neighboring gene KRAB box domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43025326-43025826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:43025827-43026327 Neighboring gene golgi associated kinase 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Goldstein JI, et al. Nat Commun, 2014 Sep 4. PMID 25187353, Free PMC Article
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    3. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33347, FLJ45880, MGC149141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 662

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134656.2 → NP_001128128.1  zinc finger protein 662 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longer isoform (2).
      Source sequence(s)
      AC092043, AK090754, AW117418, BC128085
      Consensus CDS
      CCDS46807.1
      UniProtKB/Swiss-Prot
      Q6ZS27
      Related
      ENSP00000329264.6, ENST00000328199.6
      Conserved Domains (5) summary
      smart00349
      Location:33 → 92
      KRAB; krueppel associated box
      COG5048
      Location:272 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:276 → 296
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:33 → 72
      KRAB; KRAB box
      pfam13465
      Location:316 → 341
      zf-H2C2_2; Zinc-finger double domain

    2. NM_207404.4 → NP_997287.2  zinc finger protein 662 isoform 1

      See identical proteins and their annotated locations for NP_997287.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate 5' exon, uses an alternate in-frame splice junction at the 5' end of an exon, and contains an alternate in-frame exon compared to variant 2. The resulting isoform (1) is shorter at the N-terminus, contains a single alternate aa, and contains an alternate segment compared to isoform 2.
      Source sequence(s)
      AC092043, AK090754, AK127779
      Consensus CDS
      CCDS2708.1
      UniProtKB/Swiss-Prot
      A1A4T9, F8W7S8, Q6ZNF8, Q6ZQW8, Q6ZS27
      Related
      ENSP00000405047.2, ENST00000440367.7
      Conserved Domains (3) summary
      COG5048
      Location:246 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:290 → 315
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      42906142..42919334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      42921723..42934975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZS27.1 GenPept UniProtKB/Swiss-Prot:Q6ZS27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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