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    Cnga4 cyclic nucleotide gated channel subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85258, updated on 2-May-2024

    Summary

    Official Symbol
    Cnga4provided by RGD
    Official Full Name
    cyclic nucleotide gated channel subunit alpha 4provided by RGD
    Primary source
    RGD:619844
    See related
    Ensembl:ENSRNOG00000017609 AllianceGenome:RGD:619844
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CNG4; CNG5; Cgn2; CNG-4; rOCNC2
    Summary
    Enables cGMP binding activity; intracellular cAMP-activated cation channel activity; and intracellular cGMP-activated cation channel activity. Predicted to be involved in cation transmembrane transport. Predicted to act upstream of or within sensory perception of smell. Located in perikaryon and plasma membrane. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 11.3), Heart (RPKM 1.1) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    1q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169134332..169168317)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159752357..159756369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170238959..170246858)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene similar to human chromosome 11 open reading frame 42 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene uncharacterized LOC108349007 Neighboring gene cholecystokinin B receptor Neighboring gene caveolae associated protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intracellular cyclic nucleotide activated cation channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in non-motile cilium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cyclic nucleotide-gated cation channel alpha-4
    Names
    CNCalpha4 C
    CNG channel alpha-4
    cyclic nucleotide gated cation channel
    cyclic nucleotide gated channel alpha 4
    cyclic nucleotide-gated olfactory channel subunit OCNC2
    olfactory cyclic nucleotide-gated channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053496.2NP_445948.2  cyclic nucleotide-gated cation channel alpha-4

      See identical proteins and their annotated locations for NP_445948.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001, U12623
      UniProtKB/Swiss-Prot
      Q64359, Q6Q2I4
      UniProtKB/TrEMBL
      A6I7I1, G3V898
      Related
      ENSRNOP00000023751.4, ENSRNOT00000023751.8
      Conserved Domains (5) summary
      COG0664
      Location:342519
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:348464
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:58273
      Ion_trans; Ion transport protein
      pfam16526
      Location:464535
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
      cl21455
      Location:116174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169134332..169168317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275896.1XP_063131966.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

      UniProtKB/TrEMBL
      A6I7I1, G3V898
    2. XM_063275897.1XP_063131967.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

      UniProtKB/TrEMBL
      A6I7I1, G3V898
    3. XM_063275895.1XP_063131965.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

      UniProtKB/TrEMBL
      A6I7I1, G3V898
    4. XM_063275898.1XP_063131968.1  cyclic nucleotide-gated cation channel alpha-4 isoform X1

      UniProtKB/TrEMBL
      A6I7I1, G3V898