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    mlt-3 SAM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189743, updated on 23-Nov-2023

    Summary

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    Gene symbol
    mlt-3
    Gene description
    SAM domain-containing protein
    Primary source
    WormBase:WBGene00012704
    Locus tag
    CELE_Y39C12A.1
    See related
    AllianceGenome:WB:WBGene00012704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in ecdysis, collagen and cuticulin-based cuticle. Is expressed in hypodermis. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (12222865..12227112, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Conjugative transposon protein TraM;Secreted protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans. Lažetić V, et al. Genetics, 2017 Jan. PMID 27799278, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SAM domain-containing protein
    NP_502319.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12222865..12227112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069918.4 → NP_502319.2  SAM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502319.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2L2
      Conserved Domains (3) summary
      COG0666
      Location:46 → 234
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:78 → 109
      ANK; ANK repeat [structural motif]
      pfam00536
      Location:247 → 306
      SAM_1; SAM domain (Sterile alpha motif)
    Nucleotide Protein
    Heading Accession and Version

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