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    ABLIM2 actin binding LIM protein family member 2 [ Homo sapiens (human) ]

    Gene ID: 84448, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ABLIM2provided by HGNC
    Official Full Name
    actin binding LIM protein family member 2provided by HGNC
    Primary source
    HGNC:HGNC:19195
    See related
    Ensembl:ENSG00000163995 MIM:612544; AllianceGenome:HGNC:19195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen (RPKM 7.8), brain (RPKM 4.6) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4p16.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (7965327..8158813, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (7943879..8137197, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (7967054..8160540, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7806013-7806582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7806583-7807151 Neighboring gene actin filament associated protein 1 Neighboring gene Sharpr-MPRA regulatory region 8435 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:7809617-7810117 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7827707-7828208 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:7828209-7828708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:7830049-7830549 Neighboring gene Sharpr-MPRA regulatory region 14367 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:7845474-7845654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7851945-7852446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7854640-7855140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7884073-7884574 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:7895735-7895928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7916363-7917329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7919591-7920401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7920402-7921211 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:7940549-7941053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7951399-7951898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7957833-7958334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7958335-7958834 Neighboring gene uncharacterized LOC389199 Neighboring gene Sharpr-MPRA regulatory region 6491 Neighboring gene uncharacterized LOC124900657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7973234-7973789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:7973790-7974346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15255 Neighboring gene Sharpr-MPRA regulatory region 1176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7986340-7987294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7987295-7988247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:7994807-7995347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8000331-8000831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8007792-8008380 Neighboring gene Sharpr-MPRA regulatory region 2931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8026198-8026721 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:8026730-8027230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8039172-8039672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8041509-8042464 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8050961-8051572 Neighboring gene microRNA 95 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8062037-8062764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8072999-8073862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8080453-8080952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8086980-8087888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8098780-8099499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8105045-8105756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8105757-8106466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8107177-8107886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8106467-8107176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8110453-8111188 Neighboring gene Sharpr-MPRA regulatory region 605 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8127946-8128570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8151878-8152752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8175771-8176270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8177753-8178598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8189546-8190072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8191649-8192174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:8193227-8193751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8207619-8208120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8208121-8208620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8210744-8211508 Neighboring gene guanine monophosphate synthase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8217127-8217691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8217692-8218255 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8228681-8229350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8230692-8231362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8239598-8240458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:8240459-8241317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic organisation and tissue specific expression of ABLIM2 gene in human, mouse and rat. Klimov E, et al. Biochim Biophys Acta, 2005 Jul 25. PMID 16005990
    2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
    3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
    4. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779, Free PMC Article
    5. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26534, FLJ39684, KIAA1808, MGC141918, DKFZp761F129

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding LIM protein 2
    Names
    abLIM-2
    testis tissue sperm-binding protein Li 35a

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130083.2 → NP_001123555.1  actin-binding LIM protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AJ748601, AK094798, AK097003, BC067214, BE155865, BQ267829
      Consensus CDS
      CCDS47014.1
      UniProtKB/TrEMBL
      A0A140VK02, Q19VH1
      Related
      ENSP00000393511.2, ENST00000447017.7
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:611 → 645
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 609
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001130084.2 → NP_001123556.1  actin-binding LIM protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001123556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AJ748601, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47013.1
      UniProtKB/Swiss-Prot
      E9PF39, Q08E71, Q19VH0, Q6H8Q0, Q6H8Q1, Q6NX73, Q8N3C5, Q8N9E9, Q8N9G2, Q96JL7
      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000342813.5, ENST00000341937.9
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:577 → 611
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 575
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. NM_001130085.2 → NP_001123557.1  actin-binding LIM protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001123557.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, and lacks a segment in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AJ748600, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47012.1
      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000355003.5, ENST00000361581.9
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:538 → 572
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 536
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    4. NM_001130086.2 → NP_001123558.1  actin-binding LIM protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001123558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment and uses an alternate in-frame splice site in the mid-coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AJ748601, AK097003, BC067214, BQ267829, DQ413177
      Consensus CDS
      CCDS47011.1
      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000421283.1, ENST00000505872.5
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:525 → 559
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 523
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. NM_001130087.2 → NP_001123559.1  actin-binding LIM protein 2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate in-frame exon and uses an alternate in-frame splice site in the mid-coding region, and lacks alternate in-frame segments in both the mid- and 3' coding regions, compared to variant 1. The resulting isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK094754, AK094798, AK097003, BC067214, BQ267829
      Consensus CDS
      CCDS47015.1
      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000354887.5, ENST00000361737.9
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:497 → 531
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 495
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. NM_001130088.2 → NP_001123560.1  actin-binding LIM protein 2 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR, includes an alternate in-frame exon and lacks an alternate in-frame segment in the mid-coding region, and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (7) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK094798, BC067214, BM718728
      Consensus CDS
      CCDS47016.1
      UniProtKB/TrEMBL
      B7Z6W4
      Related
      ENSP00000389410.2, ENST00000428004.6
      Conserved Domains (5) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:277 → 428
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. NM_001286688.2 → NP_001273617.1  actin-binding LIM protein 2 isoform 8

      See identical proteins and their annotated locations for NP_001273617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence, contains an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (8) is shorter at the N-terminus, lacks an alternate segment, and contains another alternate segment compared to isoform 1.
      Source sequence(s)
      AK094798, AK097003, BQ267829, DA392726
      Consensus CDS
      CCDS68669.1
      UniProtKB/Swiss-Prot
      Q6H8Q1
      Related
      ENSP00000423661.1, ENST00000514025.5
      Conserved Domains (3) summary
      pfam02209
      Location:312 → 346
      VHP; Villin headpiece domain
      pfam16182
      Location:34 → 310
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:1 → 24
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    8. NM_032432.5 → NP_115808.3  actin-binding LIM protein 2 isoform 6

      See identical proteins and their annotated locations for NP_115808.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks alternate in-frame segments in both the mid- and 3' coding regions, compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AK094798, AK097003, BC067214, BC122567, BQ267829
      Consensus CDS
      CCDS54719.1
      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000384658.3, ENST00000407564.7
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:487 → 521
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 485
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      7965327..8158813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416308.1 → XP_047272264.1  actin-binding LIM protein 2 isoform X12

    2. XM_047416301.1 → XP_047272257.1  actin-binding LIM protein 2 isoform X5

      Related
      ENSP00000518527.1, ENST00000710854.1

    3. XM_047416299.1 → XP_047272255.1  actin-binding LIM protein 2 isoform X3

    4. XM_005248030.5 → XP_005248087.1  actin-binding LIM protein 2 isoform X40

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:491 → 525
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 489
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    5. XM_005248027.5 → XP_005248084.1  actin-binding LIM protein 2 isoform X34

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:530 → 564
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 528
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    6. XM_005248029.5 → XP_005248086.1  actin-binding LIM protein 2 isoform X38

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:492 → 526
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 490
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    7. XM_005248024.5 → XP_005248081.1  actin-binding LIM protein 2 isoform X32

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:543 → 577
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 541
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    8. XM_005248022.5 → XP_005248079.1  actin-binding LIM protein 2 isoform X28

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Related
      ENSP00000504601.1, ENST00000676532.1
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:582 → 616
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 580
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    9. XM_047416307.1 → XP_047272263.1  actin-binding LIM protein 2 isoform X11

    10. XM_047416306.1 → XP_047272262.1  actin-binding LIM protein 2 isoform X10

    11. XM_017008715.3 → XP_016864204.1  actin-binding LIM protein 2 isoform X31

      UniProtKB/TrEMBL
      Q19VH1

    12. XM_005248023.5 → XP_005248080.1  actin-binding LIM protein 2 isoform X29

      UniProtKB/TrEMBL
      Q19VH1
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:576 → 610
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 574
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    13. XM_005248020.5 → XP_005248077.1  actin-binding LIM protein 2 isoform X22

      UniProtKB/TrEMBL
      Q19VH1
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:615 → 649
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 613
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    14. XM_047416310.1 → XP_047272266.1  actin-binding LIM protein 2 isoform X14

    15. XM_005248019.5 → XP_005248076.1  actin-binding LIM protein 2 isoform X21

      UniProtKB/TrEMBL
      F5GYR0, Q19VH1
      Related
      ENSP00000441255.3, ENST00000545242.6
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:616 → 650
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 614
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    16. XM_047416309.1 → XP_047272265.1  actin-binding LIM protein 2 isoform X13

    17. XM_047416300.1 → XP_047272256.1  actin-binding LIM protein 2 isoform X4

    18. XM_006713927.4 → XP_006713990.1  actin-binding LIM protein 2 isoform X37

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:502 → 536
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 500
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    19. XM_017008720.3 → XP_016864209.1  actin-binding LIM protein 2 isoform X33

      UniProtKB/TrEMBL
      A0A7I2V5G9

    20. XM_005248028.6 → XP_005248085.1  actin-binding LIM protein 2 isoform X36

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:503 → 537
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 501
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    21. XM_047416316.1 → XP_047272272.1  actin-binding LIM protein 2 isoform X30

    22. XM_047416311.1 → XP_047272267.1  actin-binding LIM protein 2 isoform X15

    23. XM_047416313.1 → XP_047272269.1  actin-binding LIM protein 2 isoform X17

    24. XM_047416312.1 → XP_047272268.1  actin-binding LIM protein 2 isoform X16

    25. XM_047416302.1 → XP_047272258.1  actin-binding LIM protein 2 isoform X6

    26. XM_006713925.4 → XP_006713988.1  actin-binding LIM protein 2 isoform X25

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:587 → 621
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 585
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    27. XM_006713924.5 → XP_006713987.1  actin-binding LIM protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:626 → 660
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 624
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    28. XM_047416305.1 → XP_047272261.1  actin-binding LIM protein 2 isoform X9

    29. XM_005248021.6 → XP_005248078.1  actin-binding LIM protein 2 isoform X24

      UniProtKB/TrEMBL
      A0A7I2V5G9
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:588 → 622
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 586
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    30. XM_047416303.1 → XP_047272259.1  actin-binding LIM protein 2 isoform X7

    31. XM_006713923.5 → XP_006713986.1  actin-binding LIM protein 2 isoform X19

      UniProtKB/TrEMBL
      A0AA34QVK8
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:627 → 661
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 625
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    32. XM_047416298.1 → XP_047272254.1  actin-binding LIM protein 2 isoform X2

    33. XM_005248017.5 → XP_005248074.1  actin-binding LIM protein 2 isoform X18

      UniProtKB/TrEMBL
      A0AA34QVK8
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:628 → 662
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 626
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    34. XM_005248014.6 → XP_005248071.1  actin-binding LIM protein 2 isoform X8

      UniProtKB/TrEMBL
      A0AA34QVK8
      Conserved Domains (6) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:667 → 701
      VHP; Villin headpiece domain
      pfam16182
      Location:282 → 665
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    35. XM_047416297.1 → XP_047272253.1  actin-binding LIM protein 2 isoform X1

    36. XM_047416315.1 → XP_047272271.1  actin-binding LIM protein 2 isoform X27

    37. XM_047416314.1 → XP_047272270.1  actin-binding LIM protein 2 isoform X26

    38. XM_011513586.4 → XP_011511888.1  actin-binding LIM protein 2 isoform X23

      UniProtKB/TrEMBL
      A0AA34QVK8
      Conserved Domains (5) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:282 → 472
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    39. XM_047416318.1 → XP_047272274.1  actin-binding LIM protein 2 isoform X43

    40. XM_017008725.2 → XP_016864214.1  actin-binding LIM protein 2 isoform X42

      UniProtKB/TrEMBL
      B7Z6W4

    41. XM_047416317.1 → XP_047272273.1  actin-binding LIM protein 2 isoform X39

    42. XM_017008723.2 → XP_016864212.1  actin-binding LIM protein 2 isoform X35

      UniProtKB/TrEMBL
      Q19VH1

    43. XM_005248031.5 → XP_005248088.1  actin-binding LIM protein 2 isoform X41

      UniProtKB/TrEMBL
      B7Z6W4
      Conserved Domains (5) summary
      cd09327
      Location:29 → 80
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85 → 140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:158 → 209
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:217 → 272
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:282 → 433
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      7943879..8137197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351058.1 → XP_054207033.1  actin-binding LIM protein 2 isoform X12

    2. XM_054351051.1 → XP_054207026.1  actin-binding LIM protein 2 isoform X5

    3. XM_054351049.1 → XP_054207024.1  actin-binding LIM protein 2 isoform X3

    4. XM_054351078.1 → XP_054207053.1  actin-binding LIM protein 2 isoform X1

    5. XM_054351061.1 → XP_054207036.1  actin-binding LIM protein 2 isoform X15

    6. XM_054351052.1 → XP_054207027.1  actin-binding LIM protein 2 isoform X6

    7. XM_054351048.1 → XP_054207023.1  actin-binding LIM protein 2 isoform X2

    8. XM_054351057.1 → XP_054207032.1  actin-binding LIM protein 2 isoform X11

    9. XM_054351056.1 → XP_054207031.1  actin-binding LIM protein 2 isoform X10

    10. XM_054351050.1 → XP_054207025.1  actin-binding LIM protein 2 isoform X4

    11. XM_054351063.1 → XP_054207038.1  actin-binding LIM protein 2 isoform X17

    12. XM_054351062.1 → XP_054207037.1  actin-binding LIM protein 2 isoform X16

    13. XM_054351055.1 → XP_054207030.1  actin-binding LIM protein 2 isoform X9

    14. XM_054351053.1 → XP_054207028.1  actin-binding LIM protein 2 isoform X7

    15. XM_054351060.1 → XP_054207035.1  actin-binding LIM protein 2 isoform X14

    16. XM_054351059.1 → XP_054207034.1  actin-binding LIM protein 2 isoform X13

    17. XM_054351066.1 → XP_054207041.1  actin-binding LIM protein 2 isoform X20

    18. XM_054351065.1 → XP_054207040.1  actin-binding LIM protein 2 isoform X19

    19. XM_054351064.1 → XP_054207039.1  actin-binding LIM protein 2 isoform X18

    20. XM_054351054.1 → XP_054207029.1  actin-binding LIM protein 2 isoform X8

    21. XM_054351074.1 → XP_054207049.1  actin-binding LIM protein 2 isoform X28

    22. XM_054351068.1 → XP_054207043.1  actin-binding LIM protein 2 isoform X22

    23. XM_054351067.1 → XP_054207042.1  actin-binding LIM protein 2 isoform X21

      UniProtKB/TrEMBL
      F5GYR0

    24. XM_054351080.1 → XP_054207055.1  actin-binding LIM protein 2 isoform X33

    25. XM_054351076.1 → XP_054207051.1  actin-binding LIM protein 2 isoform X30

    26. XM_054351071.1 → XP_054207046.1  actin-binding LIM protein 2 isoform X25

    27. XM_054351070.1 → XP_054207045.1  actin-binding LIM protein 2 isoform X24

    28. XM_054351081.1 → XP_054207056.1  actin-binding LIM protein 2 isoform X34

    29. XM_054351079.1 → XP_054207054.1  actin-binding LIM protein 2 isoform X32

    30. XM_054351077.1 → XP_054207052.1  actin-binding LIM protein 2 isoform X31

    31. XM_054351075.1 → XP_054207050.1  actin-binding LIM protein 2 isoform X29

    32. XM_054351084.1 → XP_054207059.1  actin-binding LIM protein 2 isoform X37

    33. XM_054351083.1 → XP_054207058.1  actin-binding LIM protein 2 isoform X36

    34. XM_054351087.1 → XP_054207062.1  actin-binding LIM protein 2 isoform X40

    35. XM_054351085.1 → XP_054207060.1  actin-binding LIM protein 2 isoform X38

    36. XM_054351069.1 → XP_054207044.1  actin-binding LIM protein 2 isoform X23

    37. XM_054351073.1 → XP_054207048.1  actin-binding LIM protein 2 isoform X27

    38. XM_054351072.1 → XP_054207047.1  actin-binding LIM protein 2 isoform X26

    39. XM_054351090.1 → XP_054207065.1  actin-binding LIM protein 2 isoform X43

    40. XM_054351089.1 → XP_054207064.1  actin-binding LIM protein 2 isoform X42

    41. XM_054351086.1 → XP_054207061.1  actin-binding LIM protein 2 isoform X39

    42. XM_054351082.1 → XP_054207057.1  actin-binding LIM protein 2 isoform X35

    43. XM_054351088.1 → XP_054207063.1  actin-binding LIM protein 2 isoform X41

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6H8Q1.2 GenPept UniProtKB/Swiss-Prot:Q6H8Q1

    Gene LinkOut

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