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    Ugt2b5 UDP glucuronosyltransferase 2 family, polypeptide B5 [ Mus musculus (house mouse) ]

    Gene ID: 22238, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ugt2b5provided by MGI
    Official Full Name
    UDP glucuronosyltransferase 2 family, polypeptide B5provided by MGI
    Primary source
    MGI:MGI:98900
    See related
    Ensembl:ENSMUSG00000054630 AllianceGenome:MGI:98900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M-1; Udpgt-3; Ugt2b17; Udpgt2b5
    Summary
    Predicted to enable glucuronosyltransferase activity. Predicted to act upstream of or within steroid metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human UGT2B15 (UDP glucuronosyltransferase family 2 member B15) and UGT2B17 (UDP glucuronosyltransferase family 2 member B17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 72.2) and liver E18 (RPKM 20.2) See more
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    Genomic context

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    Location:
    5 E1; 5 43.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87272805..87288199, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87124946..87140340, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B36 Neighboring gene predicted gene, 31230 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B36 pseudogene Neighboring gene predicted gene, 19418

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation. Kimura T, et al. Eur J Biochem, 1987 Nov 2. PMID 3117546
    2. The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. Burchell B, et al. DNA Cell Biol, 1991 Sep. PMID 1909870
    3. Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5. Krasnewich D, et al. Somat Cell Mol Genet, 1987 Mar. PMID 3105095
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular glucuronidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic glucuronidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronosyltransferase 2B17
    Names
    UDP-glucuronosyltransferase 2 family, member 5
    UDP-glucuronosyltransferase 2B5
    NP_033493.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009467.3 → NP_033493.3  UDP-glucuronosyltransferase 2B17 precursor

      See identical proteins and their annotated locations for NP_033493.3

      Status: VALIDATED

      Source sequence(s)
      AI118071, AK136480
      Consensus CDS
      CCDS19385.3
      UniProtKB/Swiss-Prot
      P17717
      UniProtKB/TrEMBL
      Q8K169
      Related
      ENSMUSP00000068282.7, ENSMUST00000067790.7
      Conserved Domains (2) summary
      PHA03392
      Location:8 → 489
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:24 → 527
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      87272805..87288199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17717.1 GenPept UniProtKB/Swiss-Prot:P17717

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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