Myh8 myosin heavy chain 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh8provided by RGD
Official Full Name: myosin heavy chain 8provided by RGD
Primary source: RGD:620356
See related: Ensembl:ENSRNOG00000068010 AllianceGenome:RGD:620356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process; muscle filament sliding; and skeletal muscle contraction. Predicted to be located in cytoplasm. Predicted to be part of myosin complex. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis type 7. Orthologous to human MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 11166.8) See more
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Genomic context

Location:: 10q24

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52462509..52492105)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (51963510..51993103)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (53818818..53848490)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142011 (e-PCR)
- UniSTS:224002

Myh8 (e-PCR), detects polymorphism
- UniSTS:532319

fd14a01.x1 (e-PCR)
- UniSTS:204157

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in muscle filament sliding	IEA Inferred from Electronic Annotation more info
involved_in muscle filament sliding	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-8

Names: myHC-perinatal; myosin heavy chain, skeletal muscle, perinatal; myosin, heavy chain 8, skeletal muscle, perinatal; myosin, heavy polypeptide 8, skeletal muscle, perinatal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100485.1 → NP_001093955.1 myosin-8

See identical proteins and their annotated locations for NP_001093955.1

Status: VALIDATED

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I5Y7Z0, A6HFI4

Related

ENSRNOP00000077580.1, ENSRNOT00000105953.1

Conserved Domains (8) summary

cl22853
Location:102 → 769

Motor_domain; Myosin and Kinesin motor domain

pfam00063
Location:90 → 769

Myosin_head; Myosin head (motor domain)

pfam01576
Location:849 → 1926

Myosin_tail_1; Myosin tail

pfam02736
Location:38 → 75

Myosin_N; Myosin N-terminal SH3-like domain

pfam06273
Location:1042 → 1099

eIF-4B; Plant specific eukaryotic initiation factor 4B

pfam07851
Location:1456 → 1584

TMPIT; TMPIT-like protein

cl19764
Location:1375 → 1510

COG6; Conserved oligomeric complex COG6

cl23720
Location:964 → 1097

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)