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    UPF2 UPF2 regulator of nonsense mediated mRNA decay [ Canis lupus familiaris (dog) ]

    Gene ID: 487130, updated on 5-Mar-2024

    Summary

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    Official Symbol
    UPF2provided by VGNC
    Official Full Name
    UPF2 regulator of nonsense mediated mRNA decayprovided by VGNC
    Primary source
    VGNC:VGNC:48151
    See related
    Ensembl:ENSCAFG00845000426
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See UPF2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (24741631..24844097)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (21395035..21497504)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (23426047..23528882)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (21868023..21970539)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (22711026..22813613)

    Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene proline-rich protein 2-like Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene vegetative cell wall protein gp1-like Neighboring gene uncharacterized LOC111091559 Neighboring gene uncharacterized LOC119870153 Neighboring gene proline and serine rich 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of exon-exon junction complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of nonsense transcripts 2
    Names
    UPF2 regulator of nonsense transcripts homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051806.1 Reference ROS_Cfam_1.0

      Range
      24741631..24844097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038658441.1 → XP_038514369.1  regulator of nonsense transcripts 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Related
      ENSCAFP00845000486.1, ENSCAFT00845000676.1
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    2. XM_038658440.1 → XP_038514368.1  regulator of nonsense transcripts 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    3. XM_038658442.1 → XP_038514370.1  regulator of nonsense transcripts 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JZQ0
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049262.1 Alternate UMICH_Zoey_3.1

      Range
      21868023..21970539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038469380.1 → XP_038325308.1  regulator of nonsense transcripts 2 isoform X2

      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    2. XM_038469379.1 → XP_038325307.1  regulator of nonsense transcripts 2 isoform X1

      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    3. XM_038469381.1 → XP_038325309.1  regulator of nonsense transcripts 2 isoform X3

      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

      Range
      22711026..22813613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038594384.1 → XP_038450312.1  regulator of nonsense transcripts 2 isoform X2

    2. XM_038594383.1 → XP_038450311.1  regulator of nonsense transcripts 2 isoform X1

    3. XM_038594385.1 → XP_038450313.1  regulator of nonsense transcripts 2 isoform X3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

      Range
      23426047..23528882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038530131.1 → XP_038386059.1  regulator of nonsense transcripts 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    2. XM_038530130.1 → XP_038386058.1  regulator of nonsense transcripts 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    3. XM_038530132.1 → XP_038386060.1  regulator of nonsense transcripts 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JZQ0
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21395035..21497504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022407842.2 → XP_022263550.1  regulator of nonsense transcripts 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    2. XM_022407840.2 → XP_022263548.1  regulator of nonsense transcripts 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0JZQ0, A0A8C0Q1M5, A0A8I3MCN5
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain

    3. XM_005617144.4 → XP_005617201.1  regulator of nonsense transcripts 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0JZQ0
      Conserved Domains (4) summary
      smart00543
      Location:570 → 757
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02854
      Location:775 → 985
      MIF4G; MIF4G domain
      pfam04050
      Location:1094 → 1217
      Upf2; Up-frameshift suppressor 2
      cl19727
      Location:357 → 420
      DUF1451; Zinc-ribbon containing domain
    Nucleotide Protein
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