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    cand1 cullin-associated and neddylation-dissociated 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406806, updated on 25-Apr-2024

    Summary

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    Official Symbol
    cand1provided by ZNC
    Official Full Name
    cullin-associated and neddylation-dissociated 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2872
    See related
    Ensembl:ENSDARG00000017841 AllianceGenome:ZFIN:ZDB-GENE-040426-2872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb78a05; zgc:55729; wu:fb78a05
    Summary
    Predicted to be involved in SCF complex assembly and protein ubiquitination. Predicted to be active in nucleus. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13412030..13425274)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13413181..13426425)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene pseudouridylate synthase 7 homolog-like protein Neighboring gene uncharacterized LOC101884202 Neighboring gene glutamate receptor interacting protein 1 Neighboring gene uncharacterized LOC103910424 Neighboring gene si:dkey-39a18.1 Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Sinner MF, et al. Circulation, 2014 Oct 7. PMID 25124494, Free PMC Article
    2. Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. Hensley MR, et al. PLoS One, 2016. PMID 27658201, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in SCF complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SCF complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cullin-associated NEDD8-dissociated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213485.1 → NP_998650.1  cullin-associated NEDD8-dissociated protein 1

      See identical proteins and their annotated locations for NP_998650.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047184
      UniProtKB/TrEMBL
      Q802V5
      Related
      ENSDARP00000011017.6, ENSDART00000003694.7
      Conserved Domains (6) summary
      COG1413
      Location:833 → 1031
      HEAT; HEAT repeat [General function prediction only]
      cd00020
      Location:650 → 745
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam08623
      Location:1040 → 1202
      TIP120; TATA-binding protein interacting (TIP20)
      pfam12755
      Location:515 → 586
      Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
      pfam13513
      Location:149 → 202
      HEAT_EZ; HEAT-like repeat
      sd00044
      Location:817 → 847
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      13412030..13425274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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