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    ASB5 ankyrin repeat and SOCS box containing 5 [ Homo sapiens (human) ]

    Gene ID: 140458, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ASB5provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 5provided by HGNC
    Primary source
    HGNC:HGNC:17180
    See related
    Ensembl:ENSG00000164122 MIM:615050; AllianceGenome:HGNC:17180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASB-5
    Summary
    The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 5.3), urinary bladder (RPKM 4.0) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q34.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (176213673..176277524, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (179552031..179616715, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177134824..177190373, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900182 Neighboring gene WD repeat domain 17 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:177077413-177078612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76272 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76278 Neighboring gene spermatogenesis associated 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76283 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76286 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76293 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_76294 Neighboring gene CRISPRi-validated cis-regulatory element chr4.3423 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:177240928-177241428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15817 Neighboring gene SPCS3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22166 Neighboring gene NANOG hESC enhancer GRCh37_chr4:177278841-177279359 Neighboring gene signal peptidase complex subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22168 Neighboring gene uncharacterized LOC124900817

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action. Liu P, et al. Trends Biochem Sci, 2019 Jan. PMID 30446376
    2. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
    3. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 5
    Names
    SOCS box protein ASB-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410863.1 → NP_001397792.1  ankyrin repeat and SOCS box protein 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093605
      Consensus CDS
      CCDS93672.1
      UniProtKB/TrEMBL
      A0A5F9ZHS2
      Related
      ENSP00000500617.1, ENST00000672074.1

    2. NM_080874.4 → NP_543150.1  ankyrin repeat and SOCS box protein 5 isoform 1

      See identical proteins and their annotated locations for NP_543150.1

      Status: REVIEWED

      Source sequence(s)
      AC093605, BX647857
      Consensus CDS
      CCDS3827.1
      UniProtKB/Swiss-Prot
      Q8N7B5, Q8WWX0
      UniProtKB/TrEMBL
      Q5HYF3
      Related
      ENSP00000296525.3, ENST00000296525.7
      Conserved Domains (3) summary
      cd00204
      Location:71 → 188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:288 → 329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      176213673..176277524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262759.2 → XP_005262816.1  ankyrin repeat and SOCS box protein 5 isoform X1

      See identical proteins and their annotated locations for XP_005262816.1

      UniProtKB/Swiss-Prot
      Q8N7B5, Q8WWX0
      UniProtKB/TrEMBL
      Q5HYF3
      Conserved Domains (3) summary
      cd00204
      Location:71 → 188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:288 → 329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]

    2. XM_011531617.4 → XP_011529919.1  ankyrin repeat and SOCS box protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011529919.1

      UniProtKB/Swiss-Prot
      Q8WWX0
      Related
      ENSP00000422877.1, ENST00000512254.1
      Conserved Domains (3) summary
      cd00204
      Location:18 → 135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:18 → 47
      ANK; ANK repeat [structural motif]
      cl02533
      Location:235 → 276
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      179552031..179616715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348969.1 → XP_054204944.1  ankyrin repeat and SOCS box protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8N7B5, Q8WWX0
      UniProtKB/TrEMBL
      Q5HYF3

    2. XM_054348970.1 → XP_054204945.1  ankyrin repeat and SOCS box protein 5 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWX0.1 GenPept UniProtKB/Swiss-Prot:Q8WWX0

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