NRXN1 neurexin 1 [Bos taurus (cattle)] - Gene

Summary

Gene symbol: NRXN1
Gene description: neurexin 1
See related: Ensembl:ENSBTAG00000046199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 11

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	11	NC_037338.1 (32275399..33528131, complement)

Chromosome 11 - NC_037338.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function
Title: The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function.
The structure of neurexin 1alpha reveals features promoting a role as synaptic organizer
Title: The structure of neurexin 1α reveals features promoting a role as synaptic organizer.
structural basis for neuroligin binding
Title: Structural basis for variant-specific neuroligin-binding by α-neurexin.
crystallographic analysis of the second LNS/LG domain from neurexin 1alpha
Title: Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BZ938075 (e-PCR)
- UniSTS:475921

TGLA327 (e-PCR), detects polymorphism
- UniSTS:250917

NRXN1 (e-PCR)
- UniSTS:278849

INRA199 (e-PCR), detects polymorphism
- UniSTS:251044

General protein information

Go to the top of the page Help

Preferred Names: neurexin-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109805.2 → NP_001103275.1 neurexin-1 isoform 2

See identical proteins and their annotated locations for NP_001103275.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple differences in the coding region, including the lack of multiple 5' exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. This variant encodes a beta isoform of neurexin 1.

Source sequence(s)

L27870

UniProtKB/Swiss-Prot

Q28142

Conserved Domains (3) summary

smart00294
Location:382 → 400

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:362 → 401

Syndecan; Syndecan domain

pfam02210
Location:116 → 234

Laminin_G_2; Laminin G domain
NM_174404.2 → NP_776829.1 neurexin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_776829.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This variant encodes an alpha isoform of neurexin 1.

Source sequence(s)

L14855

UniProtKB/Swiss-Prot

Q28146

Conserved Domains (6) summary

smart00294
Location:1475 → 1493

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:526 → 675

LamG; Laminin G domain

cd00054
Location:703 → 736

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1455 → 1494

Syndecan; Syndecan domain

pfam02210
Location:956 → 1084

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

Range

32275399..33528131 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059891018.1 → XP_059747001.1 neurexin-1 isoform X13
XM_059891016.1 → XP_059746999.1 neurexin-1 isoform X11
XM_059891017.1 → XP_059747000.1 neurexin-1 isoform X12
XM_059891014.1 → XP_059746997.1 neurexin-1 isoform X9
XM_059891013.1 → XP_059746996.1 neurexin-1 isoform X8
XM_059891008.1 → XP_059746991.1 neurexin-1 isoform X2
XM_059891015.1 → XP_059746998.1 neurexin-1 isoform X10
XM_059891011.1 → XP_059746994.1 neurexin-1 isoform X5
XM_059891009.1 → XP_059746992.1 neurexin-1 isoform X3
XM_059891012.1 → XP_059746995.1 neurexin-1 isoform X6
XM_059891010.1 → XP_059746993.1 neurexin-1 isoform X4
XM_059891007.1 → XP_059746990.1 neurexin-1 isoform X1
XM_024998312.2 → XP_024854080.1 neurexin-1 isoform X22

Conserved Domains (6) summary

smart00294
Location:1390 → 1408

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 632

LamG; Laminin G domain

cd00054
Location:660 → 693

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1370 → 1409

Syndecan; Syndecan domain

pfam02210
Location:904 → 1032

Laminin_G_2; Laminin G domain
XM_024998304.2 → XP_024854072.1 neurexin-1 isoform X15

Conserved Domains (6) summary

smart00294
Location:1382 → 1400

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1362 → 1401

Syndecan; Syndecan domain

pfam02210
Location:896 → 1024

Laminin_G_2; Laminin G domain
XM_024998303.2 → XP_024854071.1 neurexin-1 isoform X14

Conserved Domains (6) summary

smart00294
Location:1385 → 1403

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1365 → 1404

Syndecan; Syndecan domain

pfam02210
Location:896 → 1024

Laminin_G_2; Laminin G domain
XM_024998311.2 → XP_024854079.1 neurexin-1 isoform X21

Conserved Domains (6) summary

smart00294
Location:1423 → 1441

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 632

LamG; Laminin G domain

cd00054
Location:660 → 693

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1403 → 1442

Syndecan; Syndecan domain

pfam02210
Location:904 → 1032

Laminin_G_2; Laminin G domain
XM_024998297.2 → XP_024854065.1 neurexin-1 isoform X7

Conserved Domains (6) summary

smart00294
Location:1432 → 1450

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 632

LamG; Laminin G domain

cd00054
Location:660 → 693

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1412 → 1451

Syndecan; Syndecan domain

pfam02210
Location:913 → 1041

Laminin_G_2; Laminin G domain
XM_024998307.2 → XP_024854075.1 neurexin-1 isoform X18

UniProtKB/Swiss-Prot

Q28142

Conserved Domains (3) summary

smart00294
Location:379 → 397

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:85 → 233

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:359 → 394

Syndecan; Syndecan domain
XM_024998306.2 → XP_024854074.1 neurexin-1 isoform X17

UniProtKB/Swiss-Prot

Q28142

Conserved Domains (3) summary

smart00294
Location:409 → 427

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:85 → 263

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:389 → 424

Syndecan; Syndecan domain
XM_024998305.2 → XP_024854073.1 neurexin-1 isoform X16

UniProtKB/Swiss-Prot

Q28142

Related

ENSBTAP00000044872.5, ENSBTAT00000047691.5

Conserved Domains (3) summary

smart00294
Location:412 → 430

4.1m; putative band 4.1 homologues' binding motif

cd00110
Location:85 → 204

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:392 → 427

Syndecan; Syndecan domain
XM_024998310.2 → XP_024854078.1 neurexin-1 isoform X20

Related

ENSBTAP00000053932.3, ENSBTAT00000064537.3

Conserved Domains (2) summary

smart00294
Location:84 → 102

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:64 → 99

Syndecan; Syndecan domain
XM_024998309.2 → XP_024854077.1 neurexin-1 isoform X19

UniProtKB/TrEMBL

G3MWM9

Conserved Domains (2) summary

smart00294
Location:87 → 105

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:67 → 102

Syndecan; Syndecan domain