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    FLNC filamin C [ Canis lupus familiaris (dog) ]

    Gene ID: 482266, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FLNCprovided by VGNC
    Official Full Name
    filamin Cprovided by VGNC
    Primary source
    VGNC:VGNC:40902
    See related
    Ensembl:ENSCAFG00845022554
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 14 NC_051818.1 (7558590..7585437, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 14 NC_006596.4 (7479565..7506435, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 14 NC_049235.1 (7651043..7677902, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 14 NC_049274.1 (7763614..7790446, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 14 NC_049755.1 (7505626..7532496, complement)

    Chromosome 14 - NC_051818.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151199 Neighboring gene sperm microtubule inner protein 1 Neighboring gene ATPase H+ transporting V1 subunit F Neighboring gene uncharacterized LOC119866516 Neighboring gene coiled-coil domain containing 136 Neighboring gene transfer RNA proline (anticodon AGG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    filamin-C
    Names
    filamin C, gamma (actin binding protein 280)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051818.1 Reference ROS_Cfam_1.0

      Range
      7558590..7585437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038686192.1 → XP_038542120.1  filamin-C isoform X2

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0PHP6, A0A8I3PIG5
      Related
      ENSCAFP00845032034.1, ENSCAFT00845040905.1
      Conserved Domains (4) summary
      smart00557
      Location:1849 → 1935
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2394 → 2480
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    2. XM_038686194.1 → XP_038542122.1  filamin-C isoform X4

      UniProtKB/TrEMBL
      A0A8C0LDL5
      Conserved Domains (4) summary
      smart00557
      Location:1822 → 1908
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2367 → 2453
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_038686193.1 → XP_038542121.1  filamin-C isoform X3

      UniProtKB/TrEMBL
      A0A8C0LDL5, A0A8C0PX66, A0A8I3PGU2
      Related
      ENSCAFP00845031590.1, ENSCAFT00845040336.1
      Conserved Domains (4) summary
      smart00557
      Location:1830 → 1916
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2375 → 2461
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    4. XM_038686191.1 → XP_038542119.1  filamin-C isoform X1

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0SKS1, A0A8I3PJ64
      Related
      ENSCAFP00845031232.1, ENSCAFT00845039880.1
      Conserved Domains (4) summary
      smart00557
      Location:1857 → 1943
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2402 → 2488
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049274.1 Alternate UMICH_Zoey_3.1

      Range
      7763614..7790446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038494278.1 → XP_038350206.1  filamin-C isoform X4

      Conserved Domains (4) summary
      smart00557
      Location:1822 → 1908
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2367 → 2453
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    2. XM_038494276.1 → XP_038350204.1  filamin-C isoform X2

      Conserved Domains (4) summary
      smart00557
      Location:1849 → 1935
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2394 → 2480
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_038494275.1 → XP_038350203.1  filamin-C isoform X1

      Conserved Domains (4) summary
      smart00557
      Location:1857 → 1943
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2402 → 2488
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    4. XM_038494277.1 → XP_038350205.1  filamin-C isoform X3

      Conserved Domains (4) summary
      smart00557
      Location:1830 → 1916
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2375 → 2461
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049755.1 Alternate UNSW_CanFamBas_1.0

      Range
      7505626..7532496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038620505.1 → XP_038476433.1  filamin-C isoform X2

      Conserved Domains (4) summary
      smart00557
      Location:1849 → 1935
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2394 → 2480
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    2. XM_038620507.1 → XP_038476435.1  filamin-C isoform X4

      Conserved Domains (4) summary
      smart00557
      Location:1822 → 1908
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2367 → 2453
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_038620506.1 → XP_038476434.1  filamin-C isoform X3

      Conserved Domains (4) summary
      smart00557
      Location:1830 → 1916
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2375 → 2461
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    4. XM_038620504.1 → XP_038476432.1  filamin-C isoform X1

      Conserved Domains (4) summary
      smart00557
      Location:1857 → 1943
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2402 → 2488
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049235.1 Alternate UU_Cfam_GSD_1.0

      Range
      7651043..7677902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038556577.1 → XP_038412505.1  filamin-C isoform X4

      UniProtKB/TrEMBL
      A0A8C0LDL5
      Conserved Domains (4) summary
      smart00557
      Location:1822 → 1908
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2367 → 2453
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    2. XM_038556575.1 → XP_038412503.1  filamin-C isoform X2

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0PHP6, A0A8I3PIG5
      Conserved Domains (4) summary
      smart00557
      Location:1849 → 1935
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2394 → 2480
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_038556574.1 → XP_038412502.1  filamin-C isoform X1

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0SKS1, A0A8I3PJ64
      Conserved Domains (4) summary
      smart00557
      Location:1857 → 1943
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2402 → 2488
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    4. XM_038556576.1 → XP_038412504.1  filamin-C isoform X3

      UniProtKB/TrEMBL
      A0A8C0LDL5, A0A8C0PX66, A0A8I3PGU2
      Conserved Domains (4) summary
      smart00557
      Location:1830 → 1916
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2375 → 2461
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006596.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      7479565..7506435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022427253.2 → XP_022282961.1  filamin-C isoform X2

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0PHP6, A0A8I3PIG5
      Conserved Domains (4) summary
      smart00557
      Location:1849 → 1935
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2394 → 2480
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    2. XM_022427254.2 → XP_022282962.1  filamin-C isoform X4

      UniProtKB/TrEMBL
      A0A8C0LDL5
      Conserved Domains (4) summary
      smart00557
      Location:1822 → 1908
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2367 → 2453
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_852926.6 → XP_858019.1  filamin-C isoform X3

      UniProtKB/TrEMBL
      A0A8C0LDL5, A0A8C0PX66, A0A8I3PGU2
      Conserved Domains (4) summary
      smart00557
      Location:1830 → 1916
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2375 → 2461
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    4. XM_539385.7 → XP_539385.1  filamin-C isoform X1

      UniProtKB/TrEMBL
      A0A8C0LCW3, A0A8C0SKS1, A0A8I3PJ64
      Conserved Domains (4) summary
      smart00557
      Location:1857 → 1943
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:2402 → 2488
      Filamin; Filamin/ABP280 repeat
      cd21310
      Location:23 → 147
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:151 → 265
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
    Nucleotide Protein
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