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    MVK mevalonate kinase [ Canis lupus familiaris (dog) ]

    Gene ID: 486309, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MVKprovided by VGNC
    Official Full Name
    mevalonate kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:43509
    See related
    Ensembl:ENSCAFG00845022604
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (17839721..17861223, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (18284429..18305927)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (17848229..17869727, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (18493628..18515091)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (17830226..17851709, complement)

    Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866094 Neighboring gene uncharacterized LOC106557805 Neighboring gene metabolism of cobalamin associated B Neighboring gene uncharacterized LOC111092706

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mevalonate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mevalonate kinase
    Names
    mevalonate kinase (mevalonic aciduria)
    XP_005636378.2
    XP_005636379.2
    XP_038292914.1
    XP_038292915.1
    XP_038314945.1
    XP_038367832.1
    XP_038367833.1
    XP_038431323.1
    XP_038431324.1
    XP_038495505.1
    XP_038495506.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051830.1 Reference ROS_Cfam_1.0

      Range
      17839721..17861223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038436986.1 → XP_038292914.1  mevalonate kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0L6D2, A0A8C0NYF9, A0A8I3PG05, A0A8P0STR6
      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    2. XM_038436987.1 → XP_038292915.1  mevalonate kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0L6D2, A0A8C0NYF9, A0A8I3PG05, A0A8P0STR6
      Related
      ENSCAFP00845031252.1, ENSCAFT00845039910.1
      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049286.1 Alternate UMICH_Zoey_3.1

      Range
      18493628..18515091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038511904.1 → XP_038367832.1  mevalonate kinase isoform X1

      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    2. XM_038511905.1 → XP_038367833.1  mevalonate kinase isoform X1

      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

      Range
      17830226..17851709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038639577.1 → XP_038495505.1  mevalonate kinase isoform X1

      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    2. XM_038639578.1 → XP_038495506.1  mevalonate kinase isoform X1

      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

      Range
      17848229..17869727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038575395.1 → XP_038431323.1  mevalonate kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0L6D2, A0A8C0NYF9, A0A8I3PG05, A0A8P0STR6
      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    2. XM_038575396.1 → XP_038431324.1  mevalonate kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C0L6D2, A0A8C0NYF9, A0A8I3PG05, A0A8P0STR6
      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      18284429..18305927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005636321.4 → XP_005636378.2  mevalonate kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I3S398
      Conserved Domains (1) summary
      cl40731
      Location:10 → 336
      PLN02677; mevalonate kinase

    2. XM_005636322.2 → XP_005636379.2  mevalonate kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I3S398
      Conserved Domains (1) summary
      cl40731
      Location:10 → 336
      PLN02677; mevalonate kinase

    3. XM_038459017.1 → XP_038314945.1  mevalonate kinase isoform X3

      UniProtKB/TrEMBL
      A0A8C0L6D2, A0A8C0NYF9, A0A8I3PG05, A0A8P0STR6
      Conserved Domains (1) summary
      cl40731
      Location:10 → 388
      PLN02677; mevalonate kinase
    Nucleotide Protein
    Heading Accession and Version

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