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    TFEB transcription factor EB [ Canis lupus familiaris (dog) ]

    Gene ID: 609046, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TFEBprovided by VGNC
    Official Full Name
    transcription factor EBprovided by VGNC
    Primary source
    VGNC:VGNC:47294
    See related
    Ensembl:ENSCAFG00845015601
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (10848131..10903700, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (10397632..10453009, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (10556169..10611532, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (10378806..10434436, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (10462511..10517872, complement)

    Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene forkhead box P4 Neighboring gene uncharacterized LOC119874161 Neighboring gene MyoD family inhibitor Neighboring gene progastricsin Neighboring gene prickle planar cell polarity protein 4 Neighboring gene fibroblast growth factor receptor substrate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris. Wang XH, et al. Mol Genet Genomics, 2015 Apr. PMID 25403511

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in humoral immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LOW QUALITY PROTEIN: transcription factor EB; transcription factor EB

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051816.1 Reference ROS_Cfam_1.0

      Range
      10848131..10903700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038683487.1 → XP_038539415.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038683484.1 → XP_038539412.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_038683483.1 → XP_038539411.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_038683481.1 → XP_038539409.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Related
      ENSCAFP00845021946.1, ENSCAFT00845027878.1
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_038683485.1 → XP_038539413.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_038683486.1 → XP_038539414.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Related
      ENSCAFP00845021961.1, ENSCAFT00845027900.1
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_038683482.1 → XP_038539410.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049272.1 Alternate UMICH_Zoey_3.1

      Range
      10378806..10434436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038491793.1 → XP_038347721.1  LOW QUALITY PROTEIN: transcription factor EB

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

      Range
      10462511..10517872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038617887.1 → XP_038473815.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038617880.1 → XP_038473808.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_038617885.1 → XP_038473813.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_038617882.1 → XP_038473810.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_038617883.1 → XP_038473811.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_038617886.1 → XP_038473814.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_038617881.1 → XP_038473809.1  transcription factor EB

      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

      Range
      10556169..10611532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038554027.1 → XP_038409955.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_038554020.1 → XP_038409948.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_038554025.1 → XP_038409953.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_038554022.1 → XP_038409950.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_038554024.1 → XP_038409952.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_038554026.1 → XP_038409954.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_038554021.1 → XP_038409949.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      10397632..10453009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846234.5 → XP_851327.2  transcription factor EB

      See identical proteins and their annotated locations for XP_851327.2

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_014118430.3 → XP_013973905.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_014118428.3 → XP_013973903.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_038677972.1 → XP_038533900.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_014118431.3 → XP_013973906.1  transcription factor EB

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_005627327.4 → XP_005627384.1  transcription factor EB

      See identical proteins and their annotated locations for XP_005627384.1

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_005627325.4 → XP_005627382.1  transcription factor EB

      See identical proteins and their annotated locations for XP_005627382.1

      UniProtKB/TrEMBL
      A0A8C0K5C1, A0A8C0MCF3, A0A8C0QC61, A0A8I3NYB7
      Conserved Domains (3) summary
      cd18927
      Location:222 → 312
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
      pfam11851
      Location:317 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 158
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    Nucleotide Protein
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