MYO10 myosin X [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYO10provided by HGNC
Official Full Name: myosin Xprovided by HGNC
Primary source: HGNC:HGNC:7593
See related: Ensembl:ENSG00000145555 MIM:601481; AllianceGenome:HGNC:7593
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MyoX
Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
Expression: Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p15.1

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (16661907..16936288, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (16601148..16875413, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (16662016..16936397, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
Title: MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
Title: MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
Title: MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesisdagger.
Title: MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.
Myosin-X and talin modulate integrin activity at filopodia tips.
Title: Myosin-X and talin modulate integrin activity at filopodia tips.
Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
Title: Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.
Title: LncRNA SNHG7 enhances chemoresistance in neuroblastoma through cisplatin-induced autophagy by regulating miR-329-3p/MYO10 axis.
We demonstrated that circMYO10 is upregulated in OS tissues and cell lines. CircMYO10 activates Wnt/beta-catenin signaling by regulating miR-370-3p/RUVBL1 axis to promote H4K16Ac at the promoter region of beta-catenin/LEF1 target genes.
Title: CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling.
MYO10 represents a new clinical biomarker for this aggressive disease and due to its role in cellular motility and invasion
Title: Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.
miR-129 inhibited neuroblastoma growth and potentiated chemosensitivity by targeting MYO10
Title: miR-129 inhibits tumor growth and potentiates chemosensitivity of neuroblastoma by targeting MYO10.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G32927 (e-PCR)
- UniSTS:117505

RH123841 (e-PCR)
- UniSTS:135950

A009W42 (e-PCR)
- UniSTS:79639

STS-N35986 (e-PCR)
- UniSTS:32279

STS-N23153 (e-PCR)
- UniSTS:40730

SHGC-152276 (e-PCR)
- UniSTS:177455

D8S2279 (e-PCR)
- UniSTS:473907

RH119176 (e-PCR)
- UniSTS:139067

D5S416 (e-PCR)
- UniSTS:38984

RH12641 (e-PCR)
- UniSTS:16225

SHGC-142278 (e-PCR)
- UniSTS:171362

RH11757 (e-PCR)
- UniSTS:80509

D5S416 (e-PCR)
- UniSTS:40865

SHGC-112200 (e-PCR)
- UniSTS:168868

A001Y40 (e-PCR)
- UniSTS:22967

G19798 (e-PCR)
- UniSTS:22968

RH12416 (e-PCR)
- UniSTS:62428

SHGC-173063 (e-PCR)
- UniSTS:185311

D5S257 (e-PCR)
- UniSTS:146918

D5S2114 (e-PCR)
- UniSTS:47600

Clone Names

FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables plus-end directed microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end directed microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: unconventional myosin-X

Names: unconventional myosin-10; unconventionnal myosin-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012334.3 → NP_036466.2 unconventional myosin-X

See identical proteins and their annotated locations for NP_036466.2

Status: REVIEWED

Source sequence(s)

AC010607, AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301

Consensus CDS

CCDS54834.1

UniProtKB/Swiss-Prot

A7E2D1, O94893, Q8IVX5, Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6

UniProtKB/TrEMBL

A0A0A0MQX1

Related

ENSP00000421280.1, ENST00000513610.6

Conserved Domains (12) summary

smart00139
Location:1549 → 1695

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:58 → 739

MYSc; Myosin. Large ATPases

smart00295
Location:1704 → 1958

B41; Band 4.1 homologues

cd13202
Location:1954 → 2042

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:1215 → 1316

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:1381 → 1506

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd14873
Location:77 → 727

MYSc_Myo10; class X myosin, motor domain

pfam00169
Location:1215 → 1308

PH; PH domain

pfam00373
Location:1796 → 1958

FERM_M; FERM central domain

pfam16735
Location:883 → 933

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1705 → 1753

UBQ; Ubiquitin-like proteins

cl17171
Location:1181 → 1223

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

16661907..16936288 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006714475.4 → XP_006714538.1 unconventional myosin-X isoform X1

UniProtKB/TrEMBL

A0A0A0MQX1

Conserved Domains (12) summary

smart00139
Location:1526 → 1672

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:58 → 716

MYSc; Myosin. Large ATPases

smart00295
Location:1681 → 1935

B41; Band 4.1 homologues

cd13202
Location:1931 → 2019

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:1192 → 1293

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:1358 → 1483

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd14873
Location:77 → 704

MYSc_Myo10; class X myosin, motor domain

pfam00169
Location:1192 → 1285

PH; PH domain

pfam00373
Location:1773 → 1935

FERM_M; FERM central domain

pfam16735
Location:860 → 910

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1682 → 1730

UBQ; Ubiquitin-like proteins

cl17171
Location:1158 → 1200

PH-like; Pleckstrin homology-like domain
XM_005248307.3 → XP_005248364.1 unconventional myosin-X isoform X3

See identical proteins and their annotated locations for XP_005248364.1

UniProtKB/TrEMBL

B7ZA23

Related

ENSP00000421170.1, ENST00000505695.5

Conserved Domains (11) summary

smart00139
Location:906 → 1052

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1061 → 1315

B41; Band 4.1 homologues

cd13202
Location:1311 → 1399

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:572 → 673

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:738 → 863

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cl22853
Location:1 → 84

Motor_domain; Myosin and Kinesin motor domain

pfam00169
Location:572 → 665

PH; PH domain

pfam00373
Location:1153 → 1315

FERM_M; FERM central domain

pfam16735
Location:240 → 290

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1062 → 1110

UBQ; Ubiquitin-like proteins

cl17171
Location:538 → 580

PH-like; Pleckstrin homology-like domain
XM_011514046.3 → XP_011512348.1 unconventional myosin-X isoform X3

See identical proteins and their annotated locations for XP_011512348.1

UniProtKB/TrEMBL

B7ZA23

Related

ENSP00000425051.1, ENST00000515803.5

Conserved Domains (11) summary

smart00139
Location:906 → 1052

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1061 → 1315

B41; Band 4.1 homologues

cd13202
Location:1311 → 1399

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:572 → 673

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:738 → 863

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cl22853
Location:1 → 84

Motor_domain; Myosin and Kinesin motor domain

pfam00169
Location:572 → 665

PH; PH domain

pfam00373
Location:1153 → 1315

FERM_M; FERM central domain

pfam16735
Location:240 → 290

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1062 → 1110

UBQ; Ubiquitin-like proteins

cl17171
Location:538 → 580

PH-like; Pleckstrin homology-like domain
XM_005248306.5 → XP_005248363.1 unconventional myosin-X isoform X2

UniProtKB/TrEMBL

B7ZA23

Conserved Domains (11) summary

smart00139
Location:907 → 1053

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1062 → 1316

B41; Band 4.1 homologues

cd13202
Location:1312 → 1400

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:573 → 674

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:739 → 864

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cl22853
Location:2 → 85

Motor_domain; Myosin and Kinesin motor domain

pfam00169
Location:573 → 666

PH; PH domain

pfam00373
Location:1154 → 1316

FERM_M; FERM central domain

pfam16735
Location:241 → 291

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1063 → 1111

UBQ; Ubiquitin-like proteins

cl17171
Location:539 → 581

PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

16601148..16875413 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352663.1 → XP_054208638.1 unconventional myosin-X isoform X1
XM_054352666.1 → XP_054208641.1 unconventional myosin-X isoform X3

UniProtKB/TrEMBL

B7Z3D4
XM_054352665.1 → XP_054208640.1 unconventional myosin-X isoform X3

UniProtKB/TrEMBL

B7Z3D4
XM_054352664.1 → XP_054208639.1 unconventional myosin-X isoform X2