Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp11b2provided by RGD
Official Full Name: cytochrome P450, family 11, subfamily b, polypeptide 2provided by RGD
Primary source: RGD:2454
See related: Ensembl:ENSRNOG00000030111 AllianceGenome:RGD:2454
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALDOS; Cp45as; Cyp11b3; RNCP45AS
Summary: Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 8649.6) See more
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (108719349..108726024, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (106838590..106845004, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (116248759..116255205, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA demethylation may switch the phenotype of CYP11B2 expression from an inactive to an active state and regulate aldosterone biosynthesis.
Title: Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.
Data showed that that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients.
Title: Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
Data suggest that variations in intake of sodium and potassium act on expression of CYP11B2 in adrenal zona glomerulosa, but not on expression of CYP11B1.
Title: In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal.
Suoquan capsule can increase the mRNA expression of CYP11B2 in rats with kidney deficiency and diuresis.
Title: [The influence of suoquan capsule on the mRNA expression of CYP11B2 in deficiency of the kidney and diuresis rats].
Ang II increased the expression levels of early transcription factors NR4A1 and NR4A2 and aldosterone synthase
Title: Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells.
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Title: Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Urotensin II receptor activation in vivo in rats enhanced the adrenocortical expression of immunoreactive aldosterone synthase.
Title: Expression and functional role of urotensin-II and its receptor in the adrenal cortex and medulla: novel insights for the pathophysiology of primary aldosteronism.
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Title: Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
This study confirms transcription of CYP11B1 and CYP11B2 throughout central nervous system and demonstrates that gene transcription is subject to differential regulation by ACTH and circulating corticosteroid levels.
Title: Effects of ACTH, dexamethasone, and adrenalectomy on 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system.
Endogenous and exogenous natriuretic peptides reduced CYP11B2 mRNA expression in cultured neonatal rat cardiocytes. This may inhibit the cardiac renin-angiotensin-aldosterone system by suppressing the gene expression of CYP11B2
Title: Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

D7Wox46 (e-PCR)
- UniSTS:518681

D7Wox19 (e-PCR)
- UniSTS:118085

D7Wox16 (e-PCR)
- UniSTS:119235

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticosterone 18-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticosterone 18-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 11-beta-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 11-beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in C21-steroid hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in aldosterone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aldosterone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 11B2, mitochondrial

Names: CYPXIB2; CYPXIB3; Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase); P450(11beta,aldo); P450-Aldo-1; P450-Aldo-2; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; cytochrome P-450 11B3; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B3, mitochondrial; cytochrome P450(11beta,aldo); cytochrome P450, subfamily 11B, polypeptide 2; cytochrome P450-Aldo-1; cytochrome P450-Aldo-2; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase

NP_036670.2

EC 1.14.15.4

EC 1.14.15.5

XP_063119046.1

EC 1.14.15.4

EC 1.14.15.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.