FCAR Fc alpha receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCARprovided by HGNC
Official Full Name: Fc alpha receptorprovided by HGNC
Primary source: HGNC:HGNC:3608
See related: Ensembl:ENSG00000186431 MIM:147045; AllianceGenome:HGNC:3608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD89; FcalphaR; FcalphaRI; CTB-61M7.2
Summary: This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward bone marrow (RPKM 95.4) See more
Orthologs: all
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Genomic context

Location:: 19q13.42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (54874235..54891420)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (57968550..57985728)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (55385691..55402786)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Title: SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History.
Title: Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History.
FcalphaRI-induced cytokine production is orchestrated via upregulation of cytokine translation and caspase-1 activation, which is dependent on glycolytic reprogramming.
Title: FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming.
In transgenic mice, IgAN pathogenesis involves impaired clearance of abnormal IgA via CD89, primarily by the Kupffer cells. Conditional IgAN progression in CD89 transgenic mice thus reveals important aspects of IgAN pathogenesis.
Title: Critical Role of Kupffer Cell CD89 Expression in Experimental IgA Nephropathy.
a novel Fcar splice variant termed variant APD isolated from a healthy volunteer that lacks only the IgA-binding EC1 domain, is reported.
Title: Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it.
Findings suggest a basis for the use of Fc receptor I for IgA (FcalphaRI) as a molecular target for the treatment of lupus.
Title: Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.
induces different forms of neutrophil death, depending on the inflammatory microenvironment
Title: Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
this study examined the expression of IL-4 mRNA, IFN-c mRNA and FcaRI mRNA in tonsillar mononuclear cells of IgA nephropathy9(IgAN) patients and non-IgAN patients.
Title: Expression and correlation analysis of IL-4, IFN-γ and FcαRI in tonsillar mononuclear cells in patients with IgA nephropathy.
FCAR polymorphism is not associated with high susceptibility to IGA nephropathy in caucasians.
Title: Single nucleotidic polymorphism 844 A->G of FCAR is not associated with IgA nephropathy in Caucasians.
Abnormally glycosylated IgA1 and soluble CD89-IgA and IgA-IgG complexes, features of primary IgA nephropathy, are also present in alcoholic cirrhosis.
Title: Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-35428 (e-PCR)
- UniSTS:2564

D11S2921 (e-PCR)
- UniSTS:152074

D10S16 (e-PCR)
- UniSTS:155756

STS-X54150 (e-PCR)
- UniSTS:3508

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables IgA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in ficolin-1-rich granule membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: immunoglobulin alpha Fc receptor

Names: Fc fragment of IgA receptor; Fc fragment of IgA, receptor for

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002000.4 → NP_001991.1 immunoglobulin alpha Fc receptor isoform a precursor

See identical proteins and their annotated locations for NP_001991.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as a.1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC245128, AK290922, BC027953

Consensus CDS

CCDS12907.1

UniProtKB/Swiss-Prot

P24071, Q13603, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0

UniProtKB/TrEMBL

A0A0G2JLU6

Related

ENSP00000347714.3, ENST00000355524.8

Conserved Domains (2) summary

cd05711
Location:125 → 215

Ig2_LILR_KIR_like; Second immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, natural and similar domains

cd05751
Location:27 → 120

Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains
NM_133269.4 → NP_579803.1 immunoglobulin alpha Fc receptor isoform b precursor

See identical proteins and their annotated locations for NP_579803.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as a.2, delta66EC2, or U06) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, U43774

Consensus CDS

CCDS42622.1

UniProtKB/TrEMBL

A0A0G2JPZ4

Related

ENSP00000375605.3, ENST00000391725.7

Conserved Domains (1) summary

cl11960
Location:125 → 197

Ig; Immunoglobulin domain
NM_133271.4 → NP_579805.1 immunoglobulin alpha Fc receptor isoform c precursor

See identical proteins and their annotated locations for NP_579805.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as a.3, Rla2, deltaE2, or U08) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, S82919

Consensus CDS

CCDS12908.1

UniProtKB/TrEMBL

A0A0G2JPP7

Related

ENSP00000338257.4, ENST00000345937.8

Conserved Domains (1) summary

cl11960
Location:27 → 120

Ig; Immunoglobulin domain
NM_133272.4 → NP_579806.1 immunoglobulin alpha Fc receptor isoform d

See identical proteins and their annotated locations for NP_579806.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, D87855

Consensus CDS

CCDS12909.1

UniProtKB/TrEMBL

A0A0G2JNH4

Related

ENSP00000352218.4, ENST00000359272.8

Conserved Domains (2) summary

cd05711
Location:113 → 203

Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI

cl11960
Location:15 → 108

Ig; Immunoglobulin domain
NM_133273.4 → NP_579807.1 immunoglobulin alpha Fc receptor isoform e

See identical proteins and their annotated locations for NP_579807.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as U10) lacks alternate in-frame exons in the 5' and 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, BC027953, BX643574

Consensus CDS

CCDS42624.1

UniProtKB/TrEMBL

A0A0G2JPP7

Related

ENSP00000375606.3, ENST00000391726.7

Conserved Domains (1) summary

cl11960
Location:15 → 108

Ig; Immunoglobulin domain
NM_133274.4 → NP_579808.1 immunoglobulin alpha Fc receptor isoform f

See identical proteins and their annotated locations for NP_579808.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as U09) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, D87857

Consensus CDS

CCDS42625.1

UniProtKB/TrEMBL

A0A0G2JP11

Related

ENSP00000375603.3, ENST00000391723.7

Conserved Domains (1) summary

cl11960
Location:113 → 180

Ig; Immunoglobulin domain
NM_133277.4 → NP_579811.1 immunoglobulin alpha Fc receptor isoform g

See identical proteins and their annotated locations for NP_579811.1

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as deltaS2ECl or L10) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, D87861

Consensus CDS

CCDS12910.1

UniProtKB/Swiss-Prot

P24071

Related

ENSP00000338058.4, ENST00000353758.8

Conserved Domains (1) summary

cd05711
Location:16 → 106

Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
NM_133278.4 → NP_579812.1 immunoglobulin alpha Fc receptor isoform h

See identical proteins and their annotated locations for NP_579812.1

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as deltaS266Ec2 or U13) lacks an in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.

Source sequence(s)

AC245128, AK290922, X92559

Consensus CDS

CCDS42623.1

UniProtKB/TrEMBL

A0A0G2JM27

Related

ENSP00000375604.3, ENST00000391724.3

Conserved Domains (1) summary

cl11960
Location:113 → 185

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

54874235..54891420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438406.1 → XP_047294362.1 immunoglobulin alpha Fc receptor isoform X1
XM_011526625.4 → XP_011524927.1 immunoglobulin alpha Fc receptor isoform X1

See identical proteins and their annotated locations for XP_011524927.1

UniProtKB/TrEMBL

A0A0G2JNH4

Conserved Domains (2) summary

cd05711
Location:98 → 188

Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI

cl11960
Location:2 → 93

Ig; Immunoglobulin domain
XM_047438407.1 → XP_047294363.1 immunoglobulin alpha Fc receptor isoform X1
XM_017026474.2 → XP_016881963.1 immunoglobulin alpha Fc receptor isoform X1

UniProtKB/TrEMBL

A0A0G2JNH4

Conserved Domains (2) summary

cd05711
Location:98 → 188

Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI

cl11960
Location:2 → 93

Ig; Immunoglobulin domain

Reference GRCh38.p14 PATCHES

Genomic

NW_016107304.1 Reference GRCh38.p14 PATCHES

Range

203308..220493

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332039.1 → XP_054188014.1 immunoglobulin alpha Fc receptor isoform X1
XM_054332038.1 → XP_054188013.1 immunoglobulin alpha Fc receptor isoform X1
XM_054332040.1 → XP_054188015.1 immunoglobulin alpha Fc receptor isoform X1
XM_054332041.1 → XP_054188016.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 PATCHES

Genomic

NW_016107312.1 Reference GRCh38.p14 PATCHES

Range

20566..37751 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332051.1 → XP_054188026.1 immunoglobulin alpha Fc receptor isoform X1
XM_054332050.1 → XP_054188025.1 immunoglobulin alpha Fc receptor isoform X1
XM_054332052.1 → XP_054188027.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

519503..536649

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330151.1 → XP_054186126.1 immunoglobulin alpha Fc receptor isoform X1
XM_054330152.1 → XP_054186127.1 immunoglobulin alpha Fc receptor isoform X1
XM_054330154.1 → XP_054186129.1 immunoglobulin alpha Fc receptor isoform X2

UniProtKB/TrEMBL

A0A1P8A760
XM_054330153.1 → XP_054186128.1 immunoglobulin alpha Fc receptor isoform X1
XM_054330155.1 → XP_054186130.1 immunoglobulin alpha Fc receptor isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

778610..795785

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331498.1 → XP_054187473.1 immunoglobulin alpha Fc receptor isoform X1
XM_054331497.1 → XP_054187472.1 immunoglobulin alpha Fc receptor isoform X1
XM_054331499.1 → XP_054187474.1 immunoglobulin alpha Fc receptor isoform X1
XM_054331500.1 → XP_054187475.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

Range

856805..873900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333635.1 → XP_054189610.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333636.1 → XP_054189611.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333638.1 → XP_054189613.1 immunoglobulin alpha Fc receptor isoform X4

UniProtKB/TrEMBL

A0A1P8A760
XM_054333637.1 → XP_054189612.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_23

Genomic

NT_187671.1 Reference GRCh38.p14 ALT_REF_LOCI_23

Range

153182..170367

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333459.1 → XP_054189434.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333458.1 → XP_054189433.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333460.1 → XP_054189435.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333461.1 → XP_054189436.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_26

Genomic

NT_187674.1 Reference GRCh38.p14 ALT_REF_LOCI_26

Range

160255..177440

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333465.1 → XP_054189440.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333464.1 → XP_054189439.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333466.1 → XP_054189441.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333467.1 → XP_054189442.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_27

Genomic

NT_187675.1 Reference GRCh38.p14 ALT_REF_LOCI_27

Range

244474..261659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333471.1 → XP_054189446.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333470.1 → XP_054189445.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333472.1 → XP_054189447.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333473.1 → XP_054189448.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_28

Genomic

NT_187676.1 Reference GRCh38.p14 ALT_REF_LOCI_28

Range

150185..167370

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333479.1 → XP_054189454.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333478.1 → XP_054189453.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333480.1 → XP_054189455.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333481.1 → XP_054189456.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_29

Genomic

NT_187677.1 Reference GRCh38.p14 ALT_REF_LOCI_29

Range

151602..168787

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333485.1 → XP_054189460.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333484.1 → XP_054189459.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333486.1 → XP_054189461.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333487.1 → XP_054189462.1 immunoglobulin alpha Fc receptor isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_30

Genomic

NT_187683.1 Reference GRCh38.p14 ALT_REF_LOCI_30

Range

148453..165638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054333491.1 → XP_054189466.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333490.1 → XP_054189465.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333492.1 → XP_054189467.1 immunoglobulin alpha Fc receptor isoform X1
XM_054333493.1 → XP_054189468.1 immunoglobulin alpha Fc receptor isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

57968550..57985728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320195.1 → XP_054176170.1 immunoglobulin alpha Fc receptor isoform X1
XM_054320194.1 → XP_054176169.1 immunoglobulin alpha Fc receptor isoform X1
XM_054320196.1 → XP_054176171.1 immunoglobulin alpha Fc receptor isoform X1
XM_054320197.1 → XP_054176172.1 immunoglobulin alpha Fc receptor isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_133279.2: Suppressed sequence

Description

NM_133279.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_133280.1: Suppressed sequence

Description

NM_133280.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.