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Meniere disease

MedGen UID:
7530
•Concept ID:
C0025281
•
Disease or Syndrome
Synonym: Ménière's disease
SNOMED CT: Ménière's disease (13445001); Auditory vertigo (13445001); Ménière's syndrome (13445001); Ménière's vertigo (13445001); Menieres disease (13445001); Otogenic vertigo (13445001); Meniere syndrome (13445001); Meniere disease (13445001); Meniere disorder (13445001)
 
Monarch Initiative: MONDO:0007972
OMIM®: 156000
Orphanet: ORPHA45360

Definition

Meniere disease is a chronic illness characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure (Sajjadi and Paparella, 2008). [from OMIM]

Clinical features

From HPO
Tinnitus
MedGen UID:
52760
•Concept ID:
C0040264
•
Disease or Syndrome
Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.
See: Feature record | Search on this feature
Vertigo
MedGen UID:
53006
•Concept ID:
C0042571
•
Sign or Symptom
An abnormal sensation of spinning while the body is actually stationary.
See: Feature record | Search on this feature
Hearing impairment
MedGen UID:
235586
•Concept ID:
C1384666
•
Disease or Syndrome
A decreased magnitude of the sensory perception of sound.
See: Feature record | Search on this feature

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeniere disease
Follow this link to review classifications for Meniere disease in Orphanet.

Professional guidelines

PubMed

European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
Dizziness: Approach to Evaluation and Management.
Muncie HL, Sirmans SM, James E
Am Fam Physician 2017 Feb 1;95(3):154-162. PMID: 28145669
Diagnostic criteria for Menière's disease.
Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, Newman-Toker DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society
J Vestib Res 2015;25(1):1-7. doi: 10.3233/VES-150549. PMID: 25882471

Recent clinical studies

Etiology

Ménière's disease and allergy: Epidemiology, pathogenesis, and therapy.
Xu W, Li X, Song Y, Kong L, Zhang N, Liu J, Li G, Fan Z, Lyu Y, Zhang D, Wang H, Li N
Clin Exp Med 2023 Nov;23(7):3361-3371. Epub 2023 Sep 24 doi: 10.1007/s10238-023-01192-0. PMID: 37743423
Association Between Meniere Disease and Migraine.
Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim JH, Park B, Lee HJ, Choi HG
JAMA Otolaryngol Head Neck Surg 2022 May 1;148(5):457-464. doi: 10.1001/jamaoto.2022.0331. PMID: 35389472Free PMC Article
Progressive and Degenerative Peripheral Vestibular Disorders.
Little C, Kelly J, Cosetti MK
Otolaryngol Clin North Am 2021 Oct;54(5):959-971. Epub 2021 Jul 21 doi: 10.1016/j.otc.2021.05.015. PMID: 34301401
European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
The link between allergy and Menière's disease.
Weinreich HM, Agrawal Y
Curr Opin Otolaryngol Head Neck Surg 2014 Jun;22(3):227-30. doi: 10.1097/MOO.0000000000000041. PMID: 24573125Free PMC Article

Diagnosis

Ménière's disease: new guidelines, subtypes, imaging, and more.
Hoskin JL
Curr Opin Neurol 2022 Feb 1;35(1):90-97. doi: 10.1097/WCO.0000000000001021. PMID: 34864755
Meniere's Disease.
Gibson WPR
Adv Otorhinolaryngol 2019;82:77-86. Epub 2019 Jan 15 doi: 10.1159/000490274. PMID: 30947172
Imaging of Ménière Disease.
Bernaerts A, De Foer B
Neuroimaging Clin N Am 2019 Feb;29(1):19-28. doi: 10.1016/j.nic.2018.09.002. PMID: 30466641
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
What is Menière's disease? A contemporary re-evaluation of endolymphatic hydrops.
Gürkov R, Pyykö I, Zou J, Kentala E
J Neurol 2016 Apr;263 Suppl 1:S71-81. Epub 2016 Apr 15 doi: 10.1007/s00415-015-7930-1. PMID: 27083887Free PMC Article

Therapy

Ménière's disease: new guidelines, subtypes, imaging, and more.
Hoskin JL
Curr Opin Neurol 2022 Feb 1;35(1):90-97. doi: 10.1097/WCO.0000000000001021. PMID: 34864755
Betahistine in Ménière's Disease or Syndrome: A Systematic Review.
Van Esch B, van der Zaag-Loonen H, Bruintjes T, van Benthem PP
Audiol Neurootol 2022;27(1):1-33. Epub 2021 Jul 7 doi: 10.1159/000515821. PMID: 34233329
Meniere's Disease.
Gibson WPR
Adv Otorhinolaryngol 2019;82:77-86. Epub 2019 Jan 15 doi: 10.1159/000490274. PMID: 30947172
European Position Statement on Diagnosis, and Treatment of Meniere's Disease.
Magnan J, Özgirgin ON, Trabalzini F, Lacour M, Escamez AL, Magnusson M, Güneri EA, Guyot JP, Nuti D, Mandalà M
J Int Adv Otol 2018 Aug;14(2):317-321. doi: 10.5152/iao.2018.140818. PMID: 30256205Free PMC Article
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article

Prognosis

Association Between Meniere Disease and Migraine.
Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim JH, Park B, Lee HJ, Choi HG
JAMA Otolaryngol Head Neck Surg 2022 May 1;148(5):457-464. doi: 10.1001/jamaoto.2022.0331. PMID: 35389472Free PMC Article
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article
Menière's disease.
James AL, Thorp MA
BMJ Clin Evid 2007 Mar 1;2007 PMID: 19454061Free PMC Article
Recurrent vestibulopathy.
Leliever WC, Barber HO
Laryngoscope 1981 Jan;91(1):1-6. doi: 10.1288/00005537-198101000-00001. PMID: 6969834

Clinical prediction guides

Meniere disease subtyping: the direction of diagnosis and treatment in the future.
Zhang S, Guo Z, Tian E, Liu D, Wang J, Kong W
Expert Rev Neurother 2022 Feb;22(2):115-127. Epub 2022 Feb 22 doi: 10.1080/14737175.2022.2030221. PMID: 35057670
Progressive and Degenerative Peripheral Vestibular Disorders.
Little C, Kelly J, Cosetti MK
Otolaryngol Clin North Am 2021 Oct;54(5):959-971. Epub 2021 Jul 21 doi: 10.1016/j.otc.2021.05.015. PMID: 34301401
Menière's disease.
Espinosa-Sanchez JM, Lopez-Escamez JA
Handb Clin Neurol 2016;137:257-77. doi: 10.1016/B978-0-444-63437-5.00019-4. PMID: 27638077
Efficacy and safety of betahistine treatment in patients with Meniere's disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial).
Adrion C, Fischer CS, Wagner J, Gürkov R, Mansmann U, Strupp M; BEMED Study Group
BMJ 2016 Jan 21;352:h6816. doi: 10.1136/bmj.h6816. PMID: 26797774Free PMC Article
Meniere's disease: histopathology, cytochemistry, and imaging.
Ishiyama G, Lopez IA, Sepahdari AR, Ishiyama A
Ann N Y Acad Sci 2015 Apr;1343:49-57. Epub 2015 Mar 12 doi: 10.1111/nyas.12699. PMID: 25766597

Recent systematic reviews

Systemic pharmacological interventions for Ménière's disease.
Webster KE, Galbraith K, Harrington-Benton NA, Judd O, Kaski D, Maarsingh OR, MacKeith S, Ray J, Van Vugt VA, Burton MJ
Cochrane Database Syst Rev 2023 Feb 23;2(2):CD015171. doi: 10.1002/14651858.CD015171.pub2. PMID: 36827524Free PMC Article
Interventions for Menière's disease: an umbrella systematic review.
van Esch BF, van der Zaag-Loonen H, Bruintjes T, Kuijpers T, van Benthem PPG
BMJ Evid Based Med 2022 Aug;27(4):235-245. Epub 2021 Nov 8 doi: 10.1136/bmjebm-2020-111410. PMID: 34750154
Betahistine in Ménière's Disease or Syndrome: A Systematic Review.
Van Esch B, van der Zaag-Loonen H, Bruintjes T, van Benthem PP
Audiol Neurootol 2022;27(1):1-33. Epub 2021 Jul 7 doi: 10.1159/000515821. PMID: 34233329
Systematic review and meta-analysis of Meniett therapy for Meniere's disease.
Ahsan SF, Standring R, Wang Y
Laryngoscope 2015 Jan;125(1):203-8. Epub 2014 Jun 10 doi: 10.1002/lary.24773. PMID: 24913022
Menière's disease.
James AL, Thorp MA
BMJ Clin Evid 2007 Mar 1;2007 PMID: 19454061Free PMC Article

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