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    alas1 aminolevulinate, delta-, synthase 1 [ Oryzias latipes (Japanese medaka) ]

    Gene ID: 101158598, updated on 8-Mar-2024

    Summary

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    Gene symbol
    alas1
    Gene description
    aminolevulinate, delta-, synthase 1
    See related
    EnsemblRapid:ENSORLG00000004789
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryzias latipes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
    Orthologs
    human zebrafish all
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    Genomic context

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    See alas1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    103 current ASM223467v1 (GCF_002234675.1) 5 NC_019863.2 (10036084..10041596, complement)
    102 previous assembly ASM31367v1 (GCF_000313675.1) 5 NC_019863.1 (8472029..8477633, complement)

    Chromosome 5 - NC_019863.2Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 7 Neighboring gene POC1 centriolar protein A Neighboring gene B9 domain containing 2 Neighboring gene protein shisa-5 Neighboring gene uncharacterized LOC110015111 Neighboring gene protein shisa-5-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5-aminolevulinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in erythrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemoglobin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5-aminolevulinate synthase, nonspecific, mitochondrial
    Names
    5'-aminolevulinate synthase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM223467v1 Primary Assembly

    Genomic

    1. NC_019863.2 Reference ASM223467v1 Primary Assembly

      Range
      10036084..10041596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004068665.4 → XP_004068713.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A3P9MIM8, H2LJ45
      Related
      ENSORLP00000006029.2, ENSORLT00000006030.3
      Conserved Domains (3) summary
      COG0156
      Location:180 → 581
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      pfam09029
      Location:2 → 124
      Preseq_ALAS; 5-aminolevulinate synthase presequence
      cl18945
      Location:180 → 585
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    2. XM_020703159.2 → XP_020558818.1  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A3P9MIM8
      Conserved Domains (2) summary
      pfam09029
      Location:2 → 153
      Preseq_ALAS; 5-aminolevulinate synthase presequence
      cl18945
      Location:209 → 614
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version

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