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    GPR141 G protein-coupled receptor 141 [ Homo sapiens (human) ]

    Gene ID: 353345, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR141provided by HGNC
    Official Full Name
    G protein-coupled receptor 141provided by HGNC
    Primary source
    HGNC:HGNC:19997
    See related
    Ensembl:ENSG00000187037 MIM:609045; AllianceGenome:HGNC:19997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR13
    Summary
    GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in bone marrow (RPKM 2.2), appendix (RPKM 0.5) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GPR141 in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (37683766..37743835)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (37824251..37884325)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (37723369..37783437)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 1 Neighboring gene uncharacterized LOC124900242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18103 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37569874-37570374 Neighboring gene Sharpr-MPRA regulatory region 7218 Neighboring gene NECAP endocytosis associated 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25859 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:37745514-37745731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:37843212-37843712 Neighboring gene G protein-coupled receptor 141B, pseudogene Neighboring gene CDCA3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis. Parija M, et al. Oncotarget, 2023 May 19. PMID 37204251, Free PMC Article
    2. A genome-wide association study of periodontitis in a Japanese population. Shimizu S, et al. J Dent Res, 2015 Apr. PMID 25672891
    3. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
    4. Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific. Zouboulis CC, et al. J Eur Acad Dermatol Venereol, 2020 Jul. PMID 32031713
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxysterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 141
    Names
    G-protein coupled receptor PGR13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329993.2 → NP_001316922.1  probable G-protein coupled receptor 141

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC083860, AC083865
      Consensus CDS
      CCDS5451.1
      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001329994.2 → NP_001316923.1  probable G-protein coupled receptor 141

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC083860, AC083865
      Consensus CDS
      CCDS5451.1
      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001381946.1 → NP_001368875.1  probable G-protein coupled receptor 141

      Status: REVIEWED

      Source sequence(s)
      AC083860, AC083865
      Consensus CDS
      CCDS5451.1
      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Related
      ENSP00000334540.1, ENST00000334425.2
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_181791.3 → NP_861456.1  probable G-protein coupled receptor 141

      See identical proteins and their annotated locations for NP_861456.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 all encode the same protein.
      Source sequence(s)
      AC083860, AC083865
      Consensus CDS
      CCDS5451.1
      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Related
      ENSP00000390410.1, ENST00000447769.1
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      37683766..37743835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515374.4 → XP_011513676.1  probable G-protein coupled receptor 141 isoform X1

      Conserved Domains (1) summary
      pfam00001
      Location:150 → 393
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_011515375.4 → XP_011513677.1  probable G-protein coupled receptor 141 isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:138 → 381
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_047420331.1 → XP_047276287.1  probable G-protein coupled receptor 141 isoform X5

    4. XM_011515389.3 → XP_011513691.1  probable G-protein coupled receptor 141 isoform X7

      See identical proteins and their annotated locations for XP_011513691.1

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_047420330.1 → XP_047276286.1  probable G-protein coupled receptor 141 isoform X3

    6. XM_017012163.3 → XP_016867652.1  probable G-protein coupled receptor 141 isoform X4

      Conserved Domains (1) summary
      pfam00001
      Location:66 → 309
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    7. XM_047420332.1 → XP_047276288.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3

    8. XM_011515388.3 → XP_011513690.1  probable G-protein coupled receptor 141 isoform X7

      See identical proteins and their annotated locations for XP_011513690.1

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    9. XM_011515383.4 → XP_011513685.1  probable G-protein coupled receptor 141 isoform X6

      Conserved Domains (1) summary
      pfam00001
      Location:43 → 286
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    10. XM_011515386.3 → XP_011513688.1  probable G-protein coupled receptor 141 isoform X7

      See identical proteins and their annotated locations for XP_011513688.1

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    11. XM_011515385.3 → XP_011513687.1  probable G-protein coupled receptor 141 isoform X7

      See identical proteins and their annotated locations for XP_011513687.1

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
      Conserved Domains (2) summary
      cd14964
      Location:18 → 44
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:17 → 295
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      37824251..37884325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358134.1 → XP_054214109.1  probable G-protein coupled receptor 141 isoform X1

    2. XM_054358135.1 → XP_054214110.1  probable G-protein coupled receptor 141 isoform X2

    3. XM_054358138.1 → XP_054214113.1  probable G-protein coupled receptor 141 isoform X5

    4. XM_054358143.1 → XP_054214118.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3

    5. XM_054358136.1 → XP_054214111.1  probable G-protein coupled receptor 141 isoform X3

    6. XM_054358137.1 → XP_054214112.1  probable G-protein coupled receptor 141 isoform X4

    7. XM_054358142.1 → XP_054214117.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3

    8. XM_054358144.1 → XP_054214119.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3

    9. XM_054358139.1 → XP_054214114.1  probable G-protein coupled receptor 141 isoform X6

    10. XM_054358141.1 → XP_054214116.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3

    11. XM_054358140.1 → XP_054214115.1  probable G-protein coupled receptor 141 isoform X7

      UniProtKB/Swiss-Prot
      A4D1X7, Q0VAR5, Q7Z602, Q86SP3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z602.1 GenPept UniProtKB/Swiss-Prot:Q7Z602

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