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    FGFR1 fibroblast growth factor receptor 1 [ Gallus gallus (chicken) ]

    Gene ID: 396516, updated on 5-Mar-2024

    Summary

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    Symbol
    FGFR1provided by CGNC
    Full Name
    fibroblast growth factor receptor 1provided by CGNC
    Primary source
    CGNC:49847
    See related
    Ensembl:ENSGALG00010017332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    CEK1
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 22 NC_052553.1 (2504806..2524443, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 22 NC_052594.1 (2552138..2571772, complement)

    Chromosome 22 - NC_052553.1Genomic Context describing neighboring genes Neighboring gene Wolf-Hirschhorn syndrome candidate 1-like 1 Neighboring gene phospholipid phosphatase 5 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene transforming acidic coiled-coil containing protein 1 Neighboring gene uncharacterized LOC121107413 Neighboring gene pleckstrin homology domain containing A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis. Mitchell DL, et al. Mol Biol Cell, 2010 Aug 1. PMID 20554758, Free PMC Article
    2. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Lee PL, et al. Science, 1989 Jul 7. PMID 2544996
    3. Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library. Pasquale EB, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2473471, Free PMC Article
    4. Effect of anti-fibroblast growth factor receptor 1 antibodies on phosphorus metabolism in laying hens and their progeny chicks. Ren Z, et al. Poult Sci, 2019 Nov 1. PMID 31237331
    5. AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity. Mitchell DL, et al. Exp Cell Res, 2010 Jan 15. PMID 19699737

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anti-FGFR1 peptide antibodies decreased egg production of hens and growth performance of their progeny chicks probably by activating FGF-23 signaling and stimulating FGF-23 production.
      Title: Effect of anti-fibroblast growth factor receptor 1 antibodies on phosphorus metabolism in laying hens and their progeny chicks.
    2. FGFR1 promoter activity in skeletal muscle cells is repressed by E2F4.
      Title: Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells.
    3. BTEB1 activated the FGFR1 promoter via interaction with the Sp1-like binding site located at -59 bp within the FGFR1 promoter.
      Title: Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis.
    4. results indicate that AP-2 alpha is a transcriptional repressor of FGFR1 gene expression during skeletal myogenesis
      Title: AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity.
    5. a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development
      Title: Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
    6. Data suggest that the FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin.
      Title: FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470).
    7. FGF receptors are expressed only in epithelia of the embryonic digestive tract.
      Title: Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 1
    Names
    FGFR-1
    bFGF-R-1
    basic fibroblast growth factor receptor 1
    cek1 protein
    fibroblast growth factor receptor 1-IIIc
    tyrosine kinase receptor CEK1
    NP_990841.2
    XP_015152847.2
    XP_015152849.2
    XP_015152852.2
    XP_024998538.1
    XP_040507404.1
    XP_040507405.1
    XP_046759308.1
    XP_046787544.1
    XP_046787545.1
    XP_046787546.1
    XP_046787548.1
    XP_046787549.1
    XP_046787550.1
    XP_046787551.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205510.2 → NP_990841.2  fibroblast growth factor receptor 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000332
      UniProtKB/TrEMBL
      A0A8V0Z0L3
      Conserved Domains (6) summary
      cd05098
      Location:460 → 761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:369 → 398
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:253 → 256
      Ig; Ig strand A [structural motif]
      cd04973
      Location:25 → 117
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:151 → 245
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:253 → 357
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2504806..2524443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025142770.3 → XP_024998538.1  fibroblast growth factor receptor 1 isoform X6

      Conserved Domains (3) summary
      cd05857
      Location:73 → 157
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:180 → 269
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:372 → 673
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    2. XM_015297366.4 → XP_015152852.2  fibroblast growth factor receptor 1 isoform X5

      Conserved Domains (3) summary
      cd05857
      Location:73 → 157
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05098
      Location:376 → 677
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      cl11960
      Location:180 → 266
      Ig; Immunoglobulin domain

    3. XM_040651470.2 → XP_040507404.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/Swiss-Prot
      P21804
      Conserved Domains (6) summary
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:369 → 398
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:253 → 256
      Ig; Ig strand A [structural motif]
      cd04973
      Location:25 → 117
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:151 → 245
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:253 → 357
      Ig; Immunoglobulin domain

    4. XM_015297361.4 → XP_015152847.2  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z7L6
      Related
      ENSGALP00010024445.1, ENSGALT00010041806.1
      Conserved Domains (4) summary
      cd04973
      Location:39 → 117
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      cl11960
      Location:268 → 354
      Ig; Immunoglobulin domain

    5. XM_015297363.4 → XP_015152849.2  fibroblast growth factor receptor 1 isoform X1

      Conserved Domains (4) summary
      cd04973
      Location:39 → 117
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05098
      Location:464 → 765
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      cl11960
      Location:268 → 354
      Ig; Immunoglobulin domain

    6. XM_040651471.2 → XP_040507405.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z0L3
      Related
      ENSGALP00010024448.1, ENSGALT00010041811.1
      Conserved Domains (6) summary
      cd05098
      Location:460 → 761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam18123
      Location:369 → 398
      FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
      cd00096
      Location:253 → 256
      Ig; Ig strand A [structural motif]
      cd04973
      Location:25 → 117
      IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
      cd05857
      Location:151 → 245
      IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
      cl11960
      Location:253 → 357
      Ig; Immunoglobulin domain

    7. XM_046903352.1 → XP_046759308.1  fibroblast growth factor receptor 1 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2552138..2571772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046931595.1 → XP_046787551.1  fibroblast growth factor receptor 1 isoform X6

    2. XM_046931594.1 → XP_046787550.1  fibroblast growth factor receptor 1 isoform X5

    3. XM_046931590.1 → XP_046787546.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/Swiss-Prot
      P21804

    4. XM_046931589.1 → XP_046787545.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0Z7L6

    5. XM_046931588.1 → XP_046787544.1  fibroblast growth factor receptor 1 isoform X1

    6. XM_046931593.1 → XP_046787549.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0Z0L3

    7. XM_046931592.1 → XP_046787548.1  fibroblast growth factor receptor 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21804.1 GenPept UniProtKB/Swiss-Prot:P21804

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