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    AIFM2 apoptosis inducing factor mitochondria associated 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 479236, updated on 5-Mar-2024

    Summary

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    Official Symbol
    AIFM2provided by VGNC
    Official Full Name
    apoptosis inducing factor mitochondria associated 2provided by VGNC
    Primary source
    VGNC:VGNC:37738
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See AIFM2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (21362486..21379970, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (21219576..21236813, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (21816121..21833576, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (21260186..21277608, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (21465343..21482591, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene collagen type XIII alpha 1 chain Neighboring gene uncharacterized LOC102157087 Neighboring gene uncharacterized LOC119873933 Neighboring gene macroH2A.2 histone Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene secretion associated Ras related GTPase 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables electron-transferring-flavoprotein dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apoptosis-inducing factor 2; ferroptosis suppressor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      21362486..21379970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662813.1 → XP_038518741.1  ferroptosis suppressor protein 1 isoform X2

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. XM_038662812.1 → XP_038518740.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. XM_038662808.1 → XP_038518736.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. XM_038662807.1 → XP_038518735.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. XM_038662809.1 → XP_038518737.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    6. XM_038662810.1 → XP_038518738.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_038662811.1 → XP_038518739.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RNA

    1. XR_005425535.1 RNA Sequence

    2. XR_005425533.1 RNA Sequence

    3. XR_005425534.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      21260186..21277608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038473141.1 → XP_038329069.1  ferroptosis suppressor protein 1 isoform X2

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. XM_038473140.1 → XP_038329068.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. XM_038473143.1 → XP_038329071.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. XM_038473142.1 → XP_038329070.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. XM_038473144.1 → XP_038329072.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    6. XM_038473145.1 → XP_038329073.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_038473139.1 → XP_038329067.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RNA

    1. XR_005324119.1 RNA Sequence

    2. XR_005324117.1 RNA Sequence

    3. XR_005324118.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      21465343..21482591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038598505.1 → XP_038454433.1  ferroptosis suppressor protein 1 isoform X2

    2. XM_038598504.1 → XP_038454432.1  ferroptosis suppressor protein 1 isoform X1

    3. XM_038598503.1 → XP_038454431.1  ferroptosis suppressor protein 1 isoform X1

    4. XM_038598507.1 → XP_038454435.1  ferroptosis suppressor protein 1 isoform X3

    5. XM_038598506.1 → XP_038454434.1  ferroptosis suppressor protein 1 isoform X3

    6. XM_038598508.1 → XP_038454436.1  ferroptosis suppressor protein 1 isoform X3

    7. XM_038598509.1 → XP_038454437.1  ferroptosis suppressor protein 1 isoform X3

    RNA

    1. XR_005392438.1 RNA Sequence

    2. XR_005392436.1 RNA Sequence

    3. XR_005392437.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      21816121..21833576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038534191.1 → XP_038390119.1  ferroptosis suppressor protein 1 isoform X2

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. XM_038534190.1 → XP_038390118.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. XM_038534189.1 → XP_038390117.1  ferroptosis suppressor protein 1 isoform X1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 356
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. XM_038534193.1 → XP_038390121.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. XM_038534192.1 → XP_038390120.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    6. XM_038534194.1 → XP_038390122.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_038534195.1 → XP_038390123.1  ferroptosis suppressor protein 1 isoform X3

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RNA

    1. XR_005357926.1 RNA Sequence

    2. XR_005357924.1 RNA Sequence

    3. XR_005357925.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      21219576..21236813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_022417525.1 → XP_022273233.1  ferroptosis suppressor protein 1 isoform X2

      Conserved Domains (1) summary
      cl26176
      Location:39 → 323
      NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]

    2. XM_022417524.1 → XP_022273232.1  ferroptosis suppressor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LPQ2, A0A8P0SIE7
      Conserved Domains (1) summary
      cl26176
      Location:39 → 356
      NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]

    3. XM_005618972.3 → XP_005619029.1  ferroptosis suppressor protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005619029.1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    4. XM_005618971.4 → XP_005619028.1  ferroptosis suppressor protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005619028.1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. XM_005618973.4 → XP_005619030.1  ferroptosis suppressor protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005619030.1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    6. XM_005618976.4 → XP_005619033.1  ferroptosis suppressor protein 1 isoform X3

      See identical proteins and their annotated locations for XP_005619033.1

      Conserved Domains (1) summary
      cl39093
      Location:39 → 323
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_022417523.2 → XP_022273231.1  ferroptosis suppressor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LPQ2, A0A8P0SIE7
      Conserved Domains (1) summary
      cl26176
      Location:39 → 356
      NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]

    RNA

    1. XR_002625677.1 RNA Sequence

    2. XR_002625675.1 RNA Sequence

    3. XR_002625676.2 RNA Sequence

    Nucleotide Protein
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