kcnq1.1 potassium voltage-gated channel, KQT-like subfamily, member 1.1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcnq1.1provided by ZNC
Official Full Name: potassium voltage-gated channel, KQT-like subfamily, member 1.1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061214-5
See related: Ensembl:ENSDARG00000059798 AllianceGenome:ZFIN:ZDB-GENE-061214-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kcnq1; zgc:158384
Summary: Predicted to enable calmodulin binding activity and voltage-gated potassium channel activity. Acts upstream of or within cardiac muscle cell action potential; kidney development; and renal filtration. Predicted to be located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle membrane; and lateral plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in brain; heart; and inner ear. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (48555480..48658150)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (48282816..48385375)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle cell action potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal filtration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel subfamily KQT member 1.1

Names: potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123242.2 → NP_001116714.1 potassium voltage-gated channel subfamily KQT member 1.1

Status: PROVISIONAL

Source sequence(s)

AL928843

UniProtKB/TrEMBL

A0A8M1NIC4, B0R0K2

Related

ENSDARP00000077949.5, ENSDART00000083514.7

Conserved Domains (3) summary

pfam00520
Location:121 → 327

Ion_trans; Ion transport protein

pfam03520
Location:503 → 561

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:238 → 317

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

48555480..48658150

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166469.4 → XP_005166526.1 potassium voltage-gated channel subfamily KQT member 1 isoform X1

UniProtKB/TrEMBL

A0A286YA22, A0A8M2BDW5

Related

ENSDARP00000144025.1, ENSDART00000174474.2

Conserved Domains (3) summary

pfam00520
Location:121 → 327

Ion_trans; Ion transport protein

pfam03520
Location:491 → 549

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:238 → 317

Ion_trans_2; Ion channel