DENND5B DENN domain containing 5B [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: DENND5Bprovided by VGNC
Official Full Name: DENN domain containing 5Bprovided by VGNC
Primary source: VGNC:VGNC:71772
Locus tag: EGK_03505
See related: Ensembl:ENSMMUG00000003221
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	11	NC_041764.1 (32498250..32706761, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	11	NC_027903.1 (32405319..32610440, complement)

Chromosome 11 - NC_041764.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH65928 (e-PCR)
- UniSTS:27400

G62352 (e-PCR)
- UniSTS:139361

RH66496 (e-PCR)
- UniSTS:6517

RH102828 (e-PCR)
- UniSTS:97162

SHGC-33611 (e-PCR)
- UniSTS:59530

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DENN domain-containing protein 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041764.1 Reference Mmul_10 Primary Assembly

Range

32498250..32706761 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028829391.1 → XP_028685224.1 DENN domain-containing protein 5B isoform X7

UniProtKB/TrEMBL

A0A5F8AS62

Related

ENSMMUP00000080682.1, ENSMMUT00000107867.1

Conserved Domains (5) summary

smart00801
Location:521 → 596

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:995 → 1103

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:209 → 397

DENN; DENN (AEX-3) domain

pfam02759
Location:839 → 983

RUN; RUN domain
XM_028829393.1 → XP_028685226.1 DENN domain-containing protein 5B isoform X9

UniProtKB/TrEMBL

H9F9C6

Conserved Domains (6) summary

smart00801
Location:322 → 397

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:124 → 198

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:19 → 120

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:796 → 904

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02759
Location:640 → 784

RUN; RUN domain

cl02689
Location:987 → 1124

RUN; RUN domain
XM_028829388.1 → XP_028685221.1 DENN domain-containing protein 5B isoform X2

UniProtKB/TrEMBL

A0A5F7ZPR6, H9F9C6

Related

ENSMMUP00000067612.1, ENSMMUT00000100311.1

Conserved Domains (6) summary

smart00801
Location:499 → 574

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 120

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:973 → 1081

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:187 → 375

DENN; DENN (AEX-3) domain

pfam02759
Location:817 → 961

RUN; RUN domain

cl02689
Location:1164 → 1301

RUN; RUN domain
XM_028829389.1 → XP_028685222.1 DENN domain-containing protein 5B isoform X4

UniProtKB/TrEMBL

A0A5F7ZEN4, A0A5F8AHE8

Related

ENSMMUP00000064075.1, ENSMMUT00000094156.1

Conserved Domains (6) summary

smart00801
Location:521 → 596

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00593
Location:910 → 945

RUN; domain involved in Ras-like GTPase signaling

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:952 → 1060

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:209 → 397

DENN; DENN (AEX-3) domain

cl02689
Location:1143 → 1280

RUN; RUN domain
XM_028829387.1 → XP_028685220.1 DENN domain-containing protein 5B isoform X1

UniProtKB/TrEMBL

A0A5F8AHE8, F7DNY8

Related

ENSMMUP00000004303.4, ENSMMUT00000004565.4

Conserved Domains (6) summary

smart00801
Location:521 → 596

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:995 → 1103

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:209 → 397

DENN; DENN (AEX-3) domain

pfam02759
Location:839 → 983

RUN; RUN domain

cl02689
Location:1186 → 1323

RUN; RUN domain
XM_028829392.1 → XP_028685225.1 DENN domain-containing protein 5B isoform X8

UniProtKB/TrEMBL

A0A5F8AHE8

Conserved Domains (6) summary

smart00801
Location:344 → 419

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00799
Location:146 → 220

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:818 → 926

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02759
Location:662 → 806

RUN; RUN domain

cl02689
Location:1009 → 1146

RUN; RUN domain
XM_028829390.1 → XP_028685223.1 DENN domain-containing protein 5B isoform X6

UniProtKB/TrEMBL

H9F9C6

Conserved Domains (6) summary

smart00801
Location:421 → 496

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:1 → 42

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:895 → 1003

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:109 → 297

DENN; DENN (AEX-3) domain

pfam02759
Location:739 → 883

RUN; RUN domain

cl02689
Location:1086 → 1223

RUN; RUN domain
XM_015151393.2 → XP_015006879.1 DENN domain-containing protein 5B isoform X11

UniProtKB/TrEMBL

A0A663D722, A0A8J8XVA9, F7DNZ4, G7N6N1, H9F9C6

Related

ENSMMUP00000004302.3, ENSMMUT00000004564.4

Conserved Domains (6) summary

smart00801
Location:534 → 609

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:82 → 155

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:971 → 1079

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:222 → 410

DENN; DENN (AEX-3) domain

pfam02759
Location:815 → 959

RUN; RUN domain

cl02689
Location:1162 → 1299

RUN; RUN domain
XM_015151389.2 → XP_015006875.1 DENN domain-containing protein 5B isoform X3

UniProtKB/TrEMBL

A0A5F8A6B2, A0A5F8AHE8

Related

ENSMMUP00000073483.1, ENSMMUT00000089435.1

Conserved Domains (6) summary

smart00801
Location:521 → 596

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 142

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:958 → 1066

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:209 → 397

DENN; DENN (AEX-3) domain

pfam02759
Location:802 → 946

RUN; RUN domain

cl02689
Location:1149 → 1286

RUN; RUN domain
XM_015151390.2 → XP_015006876.1 DENN domain-containing protein 5B isoform X5

UniProtKB/TrEMBL

H9F9C6

Related

ENSMMUP00000058850.2, ENSMMUT00000067883.2

Conserved Domains (6) summary

smart00801
Location:499 → 574

dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins

smart00800
Location:19 → 120

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

cd01757
Location:936 → 1044

PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...

pfam02141
Location:187 → 375

DENN; DENN (AEX-3) domain

pfam02759
Location:780 → 924

RUN; RUN domain

cl02689
Location:1127 → 1264

RUN; RUN domain
XM_028829394.1 → XP_028685227.1 DENN domain-containing protein 5B isoform X10

Conserved Domains (2) summary

smart00799
Location:124 → 198

DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN

smart00800
Location:19 → 120

uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins