Nifk nucleolar protein interacting with the FHA domain of MKI67 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nifkprovided by MGI
Official Full Name: nucleolar protein interacting with the FHA domain of MKI67provided by MGI
Primary source: MGI:MGI:1915199
See related: Ensembl:ENSMUSG00000026377 AllianceGenome:MGI:1915199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mki67ip; C130020J04Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in condensed nuclear chromosome; cytoplasm; and nucleoplasm. Predicted to be active in nucleolus. Orthologous to human NIFK (nucleolar protein interacting with the FHA domain of MKI67). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 22.8), liver E14 (RPKM 16.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.14 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (118249573..118261561)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (118321843..118333831)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIFK, an RNA-binding nucleolar protein interacting with the fork-head associated domain of the proliferation marker protein Ki-67, is widely expressed in adult mouse tissues and up-regulated in denervated hind limb muscle
Title: The nifk gene is widely expressed in mouse tissues and is up-regulated in denervated hind limb muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI852665 (e-PCR)
- UniSTS:164124

NoName (e-PCR)
- UniSTS:234189

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MKI67 FHA domain-interacting nucleolar phosphoprotein

Names: Mki67 (FHA domain) interacting nucleolar phosphoprotein; mNIFK; nucleolar protein interacting with the FHA domain of pKI-67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026472.4 → NP_080748.3 MKI67 FHA domain-interacting nucleolar phosphoprotein

See identical proteins and their annotated locations for NP_080748.3

Status: VALIDATED

Source sequence(s)

BB727432, BC058559, BY289326

Consensus CDS

CCDS15222.1

UniProtKB/Swiss-Prot

Q8BMV9, Q8BVL4, Q91VE6

Related

ENSMUSP00000027626.7, ENSMUST00000027626.13

Conserved Domains (3) summary

COG0724
Location:48 → 156

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12307
Location:48 → 121

RRM_NIFK_like; RNA recognition motif in nucleolar protein interacting with the FHA domain of pKI-67 (NIFK) and similar proteins

pfam12196
Location:251 → 288

hNIFK_binding; FHA Ki67 binding domain of hNIFK