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Select item 52571.

Calyx of Held synaptic development: globular bushy cells

Analysis of calyx of Held globular bushy cells at different maturation stages: P3, P8 and P21. Calyx of Held presynaptic terminals in the auditory brainstem develop into axosomatic synapses. Results provide insight into mechanisms underlying development of mammalian synaptic structure and function.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 3 cell type, 3 development stage sets

Platform:: GPL1355
Series:: GSE49599
20 Samples

Download data: CEL

DataSet

Accession:: GDS5257

ID:: 5257

Select item 50632.

Conventional cigarette or modified-risk tobacco product smoke effect on lung bronchial epithelium: dose response

Analysis of left lung bronchi from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5063

ID:: 5063

Select item 50623.

Conventional cigarette or modified-risk tobacco product smoke effect on lung parenchyma: dose response

Analysis of left lung parenchyma from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5062

ID:: 5062

Select item 50614.

Conventional cigarette or modified-risk tobacco product smoke effect on nasal respiratory epithelium: dose response

Analysis of nasal epithelia from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5061

ID:: 5061

Select item 53905.

Whey protein hydrolysate diet effect on exercised epitrochlearis muscle

Analysis of epitrochlearis muscle from males exercised for 2hr then fed a whey protein hydrolysate (WPH) diet or a control diet with an identical amino acid composition (AAM). Results provide insight into the molecular basis of the greater post-exercise muscle protein synthesis in the WPH group.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL1355
Series:: GSE49486
8 Samples

Download data: CEL

DataSet

Accession:: GDS5390

ID:: 5390

Select item 48736.

Hepatoma cell line overexpressing human Sar1 components of the coat protein complex II transport machinery

Analysis of McArdle-RH7777 hepatoma cell lines overexpressing human SAR1A, SAR1B, or a constitutively active mutant SAR1B that cannot hydrolyze GTP to support coat protein complex II (COPII) vesicle assembly. Results provide insight into roles of the SAR1 isoforms in the COPII transport machinery.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL1355
Series:: GSE52969
25 Samples

Download data: CEL

DataSet

Accession:: GDS4873

ID:: 4873

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 49547.

Cobalt effect on liver cell line MH1C1: dose response

Analysis of MH1C1 liver cells exposed to 160 or 310 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:: GPL1355
Series:: GSE51207
12 Samples

Download data: CEL

DataSet

Accession:: GDS4954

ID:: 4954

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 49538.

Cobalt effect on liver cell line H4IIEC3: dose response

Analysis of H4IIEC3 liver cells exposed to 29 or 62 uM cobalt chloride. Cobalt (Co) is a heavy metal found naturally in low concentrations and used in military and industrial applications. Co exposure can result in adverse health effects. Results provide insight into the mechanisms of Co toxicity.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 agent, 3 dose sets

Platform:: GPL1355
Series:: GSE51207
12 Samples

Download data: CEL

DataSet

Accession:: GDS4953

ID:: 4953

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 52529.

Bacterial lipopolysaccharide endotoxin stimulation effect on hepatic stellate cells: time course (experiment 1)

Analysis of hepatic stellate cells (HSCs) cultured with LPS for 1, 3, 6, 12, 24 hr. During exposure to toxins such as LPS, the liver suffers inflammatory injury. Results provide insight into molecular mechanisms underlying hepatic inflammatory and immune responses.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 5 time sets

Platform:: GPL1355
Series:: GSE49980
11 Samples

Download data: CEL

DataSet

Accession:: GDS5252

ID:: 5252

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 525110.

Bacterial lipopolysaccharide endotoxin stimulation effect on hepatic stellate cells: time course (experiment 2)

Analysis of hepatic stellate cells (HSCs) cultured with LPS for 1 and 24 hr. During exposure to toxins such as LPS, the liver suffers inflammatory injury. Results provide insight into molecular mechanisms underlying hepatic inflammatory and immune responses.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 2 time sets

Platform:: GPL1355
Series:: GSE49980
8 Samples

Download data: CEL

DataSet

Accession:: GDS5251

ID:: 5251

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 524611.

Oligodendroglial cell model of multiple system atrophy: time course

Analysis of oligodendroglia stably expressing α-synuclein and transiently expressing p25α for up to 16 hrs. Coexpression of α -synuclein and p25α causes a degenerative phenotype modeling multiple system atrophy (MSA). Results provide insight into the molecular basis of MSA pathogenesis.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol, 3 time sets

Platform:: GPL1355
Series:: GSE51781
12 Samples

Download data: CEL

DataSet

Accession:: GDS5246

ID:: 5246

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 560412.

Fibroblast growth factor 2 effect on lens epithelia explant cultures: time course

Analysis of lens explant cultures grown overnight in the presence of 5 ng/mL FGF2 to promote proliferation and survival, then treated with 100 ng/mL FGF2 for up to 24hr to induce differentiation. Results provide insight into the molecular basis of FGF2-induced lens fiber cell differentiation.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 growth protocol, 5 time sets

Platform:: GPL1355
Series:: GSE50604
10 Samples

Download data: CEL

DataSet

Accession:: GDS5604

ID:: 5604

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 493513.

Pancreatic and duodenal homeobox 1 overexpression effect on primary pancreatic islets

Analysis of primary islets transduced with adenovirus overexpressing pancreatic and duodenal homeobox 1 (Pdx-1). Homeodomain transcription factor Pdx-1 has key roles in pancreatic development and β-cell function. Results provide further insight into the role of Pdx-1 in pancreatic islets.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL1355
Series:: GSE49786
15 Samples

Download data: CEL

DataSet

Accession:: GDS4935

ID:: 4935

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 493714.

Neonatal and adult pancreatic beta cells

Analysis of β-cells from neonatal (postnatal day 2-3) and adult (10 wk old) Wistar rats. Neonatal β-cells are developmentally immature and, therefore, less glucose responsive. Results provide insight into molecular mechanisms underlying the acquisition of mature glucose responsiveness.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 age, 2 cell type sets

Platform:: GPL1355
Series:: GSE47174
11 Samples

Download data: CEL

DataSet

Accession:: GDS4937

ID:: 4937

Select item 484815.

Chloroprene effect on rat lung: dose response and time course

Analysis of lungs of F344 females exposed to 0 to 200 ppm chloroprene (CR) for 5 or 15 days. CR, a monomer used in the production of neoprene elastomers, generates multiorgan tumors in mouse and rat cancer bioassays. Compared to mice (GDS4847), F344 rats are insensitive to CR-induced lung tumors.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 agent, 5 dose, 2 time sets

Platform:: GPL1355
Series:: GSE40795
50 Samples

Download data: CEL

DataSet

Accession:: GDS4848

ID:: 4848

Select item 433216.

Interleukin 1β effect on insulinoma cell line overexpressing pancreatic duodenum homeobox 1: time course

Analysis of pancreatic duodenum homeobox 1 (Pdx1)-overexpressing, INS-1ab insulinoma cell line exposed to Interleukin 1b (IL-1β) cytokine for up to 24 hrs. Results provide insight into the molecular mechanisms underlying Pdx1-driven potentiation of beta cell sensitivity to IL-1β.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent, 2 genotype/variation, 5 time sets

Platform:: GPL1355
Series:: GSE40642
56 Samples

Download data: CEL

DataSet

Accession:: GDS4332

ID:: 4332

Select item 434417.

Diet-induced model of obesity: mesenteric adipose tissue surrounding pancreas

Analysis of adipose depot surrounding pancreas from cafeteria diet fed Wistar males. In obesity, β-cell mass increases in response to rising insulin demand; this β-cell plasticity is essential to avoid hyperglycemia onset. Results provide insight into molecular basis of β-cell mass adaptation.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 2 disease state, 2 protocol sets

Platform:: GPL1355
Series:: GSE36935
5 Samples

Download data: CEL

DataSet

Accession:: GDS4344

ID:: 4344

Select item 503218.

Early postnatal nerve tissue response to acrylamide: sciatic nerve

Analysis of sciatic nerve from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1355
Series:: GSE29004
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5032

ID:: 5032

Select item 503119.

Early postnatal nerve tissue response to acrylamide: spinal cord

Analysis of spinal cord from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1355
Series:: GSE29004
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5031

ID:: 5031

Select item 461220.

Early postnatal nerve tissue response to acrylamide: cerebellum

Analysis of cerebellum from 3 week-old male Wistar pups treated daily with acrylamide (30 mg/kg) for 21 days. Acrylamide is a type-2 alkene monomer with established human neurotoxic effects. Results provide insight into the molecular basis of acrylamide neurotoxicity in developing nervous tissue.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1355
Series:: GSE29004
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4612

ID:: 4612

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