GEO DataSets

(Submitter supplied) Liver sinusoidal endothelial cells (LSEC) of both Lyve-1-KO (B6.129S1-Lyve1tm1Lhua/J (JAX stock #006221)) and Ctrl mice were isolated and mRNA were comparatively analyzed by a microarray (Affimetryx). Even though there was no single gene significantly dysregulated, an overall representation analysis of HALLMARK pathways revealed regulation of Myc targets as well as immunological pathways involved in TNF-α, Interferon-α or -γ signaling.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL19103 GPL18802

23 Samples

Download data: CEL

(Submitter supplied) Residual disease represents a major obstacle to the successful treatment of breast cancer, however little is known about the biology of residual tumor cells in vivo. To identify genes differentially expressed in vivo in residual tumor cells compared to primary tumor cells or recurrent tumor cells, we used flow cytometry to isolate GFP-labeled tumor cells from primary, residual, or recurrent tumors grown orthotopically in nu/nu mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

11 Samples

Download data: CEL

(Submitter supplied) Mature myeloid cells play a crucial role in the pathogenesis of Crohn disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. Here we show that Trim33 mRNA level is decreased in CD patient’s blood monocytes and characterize TRIM33 functions in monocytes during dextran sulfate sodium (DSS) induced colitis. Mice deleted for trim33 only in mature myeloid cells (Trim33-/- mice) display an impaired resolution of colonic inflammation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

12 Samples

Download data: CEL

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

16 Samples

Download data: CEL

(Submitter supplied) Skeletal muscle regeneration is a highly dynamics process. The study aims at investigating gene expression by endothelial cells and satellite/myogenic cells during this process, in mouse, after a toxic injury

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

24 Samples

Download data: CEL

(Submitter supplied) Microarray analysis was performed in order to detail the global changes of gene expression in Fancg -/- embryonic Primordial Germ Cells and decipher molecular pathways underlying defects of primordial germ cell development in KO embryos.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

6 Samples

Download data: CEL

(Submitter supplied) To analyze expression differences between Trp53 pro-and deficient as well as Atm pro- and deficient murine CLL tumors developing in the Eµ-TCL1 mouse model, we analyzed splenocytes isolated from heavily infiltrated spleens of sick mice. To investigate differences in the response to cyclophosphamide, we also analyzed splenocytes from leukemic animals that were isolated twelve hours after intraperitoneal injection of cyclophosphamide.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

17 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL16311 GPL18802 GPL22598

26 Samples

Download data: CEL

(Submitter supplied) Microvascular endothelial cells (EC) are increasingly recognized as organ-specific gatekeepers of their microenvironment. Microvascular EC instruct neighboring cells in their organ-specific vascular niches by angiocrine factors that comprise secreted growth factors/angiokines, but also extracellular matrix molecules and transmembrane proteins. The molecular regulators, however, that drive organ-specific microvascular transcriptional programs and thereby regulate angiodiversity, are largely elusive. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

6 Samples

Download data: CEL

(Submitter supplied) A better understanding of molecular changes during oral tumorigenesis may help defining new personalized prevention strategies. In order to test this hypothesis, we analyzed whole-genome expression changes in a murine model of oral carcinogenesis, induced by an oral carcinogen (4-NQO) We generated genome-wide expression profiles of microdissected cells from murine tongue at each step of oral tumorigenesis: normal mucosa, hyperplasia, dysplasia and tumor.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

12 Samples

Download data: CEL

(Submitter supplied) Regeneration of the adult skeletal muscle tissue relies on a population of muscle stem cells called satellite cells. During tissue repair, satellite cells exhibit active canonical Wnt/beta-catenin signaling. To identify genes that become transcribed following activation of the Wnt/β-Catenin pathway in satellite cells, we performed microarray analysis of primary myoblasts expressing an active form of beta-catenin

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

6 Samples

Download data: CEL

(Submitter supplied) Aging animals undergo a variety of changes in molecular processes. Among these, the cellular circadian clock has been shown to change as animals age. Moreover, there is evidence that also core circadian clock proteins could influence the ageing behavior of vertebrates. To investigate the interplay between aging and the circadian clock, we studied circadian mRNA expression in skeletal muscles from young (8 weeks) and aged (80 weeks) mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

32 Samples

Download data: CEL

(Submitter supplied) Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions and its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalyzing the production of itaconic acid from cis-aconitic acid, a tricarboxylic acid (TCA) cycle intermediate. Itaconic acid possesses specific antimicrobial properties inhibiting isocitrate lyase, the first enzyme of the glyoxylate shunt, an anaplerotic pathway that bypasses the TCA cycle and enables bacteria to survive on limited carbon conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL15034 GPL18802

12 Samples

Download data: CEL

(Submitter supplied) Meiosis is a specialized division that is specifically engaged in germ cells. This program is finely and dichotomically regulated: germ cells enter meiosis at fetal life in ovaries (13.5 dpc) and only at post-natal life in testes (8 dpp). We used microarrays to determine the gene expression modifications in Meioc mutant gonads displaying early meiotic defects.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

8 Samples

Download data: CEL

(Submitter supplied) Calcium/calmodulin-dependent protein kinase II (CaMKII) was suggested to mediate ischemic myocardial injury and adverse cardiac remodeling. However, the specific functions of the CaMKII isoforms and splice variants in ischemia/reperfusion (I/R) injury have not been investigated yet. Thus, we studied the roles of the CaMKII isoforms and splice variants in I/R by the use of various CaMKII mutant mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18802

18 Samples

Download data: CEL